A simple classroom teaching technique to help students understand Michaelis-Menten kinetics

A new, simple classroom technique helps cell biology students understand principles of Michaelis-Menten enzyme kinetics. A student mimics the enzyme and the student's hand represents the enzyme's active site. The catalytic event is the transfer of marbles (substrate molecules) by hand from one plastic container to another. As predicted, increases in marble concentration increase the number of marbles transferred per unit time (initial rate, V(0)) until the turnover number becomes rate limiting and V(0) approaches the maximum velocity (V(max)), as described by the Michaelis-Menten equation. With this demonstration, students visualize an important concept: the turnover number is constant and independent of marble concentration. A student assessment of this exercise showed that it helped students visualize the turnover number and V(max) but not K(m), the marble concentration at which V(0) is one-half V(max). To address the concept of K(m), we use supplemental laboratory and lecture exercises. This exercise with plastic containers and marbles is equally suited to demonstrate the kinetics of carrier-mediated membrane transport. We conclude that this exercise helps students visualize the turnover number and V(max) and gives students important insights into the kinetic parameters used to characterize the catalytic activity of enzymes and membrane transporters.     

Federal funding and the rate and direction of inventive activity

Leveraging a new measure of patent citation trees (Corredoira and Banerjee, 2015), we demonstrate that research funded by the federal government is associated with more active and diverse technological trajectories. Our findings tie government funding to breakthrough inventions. The differences are especially evident at the upper percentiles of the distribution of long term patent influence and stem primarily from research conducted outside the federal government and sponsored by the DOD, HHS and NSF. Government funded patents are inputs into a broader range of technologies. Additional analyses indicate that federal programs invest in some technological areas that private corporations eschew, and federally funded university patents are in different technological classes than non-federally funded university patents. In this sense, the government may play an irreplaceable role in the rate and direction of inventive activity.“Generally speaking, the scientific agencies of Government are not so concerned with immediate practical objectives as are the laboratories of industry nor, on the other hand, are they as free to explore any natural phenomena without regard to possible economic applications as are the educational and private research institutions.” - Vannevar Bush, Science the Endless Frontier”, 1945.     

Neuromuscular,biomechanical, and energetic adjustments following repeated bouts of downhill running

Purpose:This study used downhill running as a model to investigate the repeated bout effect(RBE) on neuromuscular performance,running biomechanics,and metabolic cost of running.Methods:Ten healthy recreational male runners performed two 30-min bouts of downhill running(DR1 and DR2) at a-20% slope and 2.8 m/s3 weeks apart.Neuromuscular fatigue,level running biomechanics during slow and fast running,and running economy parameters were recorded immediately before and after the downhill bouts,and at...     

Developing ‘Home-Grown’ Talent: Pacific Island Rugby Labour and the Victorian Rugby Union

The last 20 years has seen a great increase in Pacific Islander migration to Australia and also a subsequent rise in the number of Australians from Pacific island backgrounds. Perhaps one of the most visible spheres where this migratory phenomenon can be witnessed is in the massive over-representation of Pacific Islanders in both rugby codes. This paper examines the effects of professionalisation and the Super Rugby expansion into a ‘non-rugby’ state and subsequent efforts of the Victorian Rugby Union (VRU) to develop ‘home-grown’ talent, namely through its Pacific Island Programme. Whilst a minority sport in Australian Rules football centric Melbourne, rugby has grown considerably over the past decade, primarily because of the influx of players, especially junior ones, from Pacific Island backgrounds. The VRU has recognised this by developing a variety of rugby programmes focusing on the outer suburbs of Melbourne (away from its traditional base in the private schools) in response to the settling patterns of Pacific Islanders and their involvement in the game. This paper considers how such focus on Pacific Islander talent facilitates pathways to elite and professional rugby opportunities and thus contributes to the creation of the rugby labour migrant.     

Exploring the deep-level reasoning questions effect during vicarious learning among eighth to eleventh graders in the domains of computer literacy and Newtonian physics

This paper tested the deep-level reasoning questions effect in the domains of computer literacy between eighth and tenth graders and Newtonian physics for ninth and eleventh graders. This effect claims that learning is facilitated when the materials are organized around questions that invite deep-reasoning. The literature indicates that vicarious learners in college student populations show greater pretest to posttest learning gains when presented with deep-level reasoning questions before each content sentence, than when deep-level questions are omitted, or when learners interact with an intelligent tutoring system. This effect holds for vicarious learners across grade levels and domains.     

Complexity Science and Education: Reconceptualizing the Teacher’s Role in Learning

This writing is structured around the question, "What is teaching?" Drawing on complexity science, we first seek to demonstrate the tremendously conflicted character of contemporary discussions of teaching. Then we offer two examples of teaching that we use to illustrate the assertion that what teaching is can never be reduced to or understood in terms of what the teacher does or intends. Rather, teaching must be understood in terms of its complex contributions to new, as-yet-unimaginable collective possibilities.     

Fear of injury in gymnastics: self-efficacy and psychological strategies to keep on tumbling

The aim of this study was to examine female gymnasts' fear of injury, their sources of self-efficacy and the psychological strategies used to overcome their fears. The participants were 10 female gymnasts aged 12 - 17 years. They had all taken part in competitive gymnastics and had experienced some type of injury during their careers. Individual interviews were conducted using a structured interview guide. Data were analysed using an inductive content analysis. The results indicated that gymnasts were most fearful of injuries because of the difficulty in returning from an injury and being unable to participate in practices and competitions while injured. Gymnasts described aspects of their past performance experience, such as success, consistency and communication with significant others, as important sources of self-efficacy. Some examples of psychological strategies used to overcome their fear of injury were mental preparation (e.g. imagery, relaxation), just "going for a skill" and the coaches' influence.     

THE EFFECT OF ACADEMIC FACTORS ON TRANSFER STUDENT PERSISTENCE AND GRADUATION: A COMMUNITY COLLEGE TO LIBERAL ARTS COLLEGE CASE STUDY

Critics contend that enrollment in a community college lessens the likelihood that a student will complete a bachelor's degree (S. Brint & J. Karabel, 1989). A number of studies have examined personal, demographic, and environmental characteristics that influence the academic performance of community college transfer students. This research has included characteristics that are not readily available to admissions representatives at four‐year institutions, and studies have not considered the private, liberal arts college as the senior institution.

The purpose of this study was to identify easily ascertainable characteristics that occur prior to transfer and to assess the relationship of these characteristics to persistence and baccalaureate attainment at a private, liberal arts college. Two academic factors related to persistence and graduation were included in the methodology: completion of the associate (AA) degree and community college grade point average (GPA) The subjects for the study were 200 students who completed the AA degree and transferred from one of three community colleges to a private, liberal arts college over a 5‐year period.

Results indicated that whereas completion of the AA degree resulted in a higher persistence/graduation rate, completion of the AA degree with a community college GPA of 3.0 or higher increased the persistence/graduation rate to a level equal to that of native students.     

Causes and consequences of student evaluation of instruction

Student evaluation of course quality was examined as an intervening variable in a path model with seven input variables and the following two output variables: (1) whether students would recommend the course to others, and (2) students' plans to take more courses in the discipline. Student evaluation of the lecturer was the most powerful input variable for the intervening variable course rating. Class format, defined as lecture or lecture with small groups, did not affect course ratingper se but did relate to students' attitudes toward taking more courses in the discipline. Lecturer and textbook evaluation had significant independent effects on whether the student would recommend the course to others. The major implication for university departments is that quality of instruction in introductory courses has impact on future enrollment plans.