商丘市城镇体育人口现状调查及对策研究

采用文献资料、问卷调查和数理统计等方法,对商丘市城镇体育人口的发展现状进行调查研究.结果表明:商丘市城镇体育人口年龄结构不均衡,体育人口文化程度较高,体育人口中非体力劳动者职业分布比较均衡,以体力劳动为主的群体参与体育锻炼程度较低,在锻炼项目上以场所容易获得、消费较少的"走"和"跑步"为主,锻炼的动机主要是为了获得身体生理机能方面的提高,且整体体育消费水平较低.     

以就业为导向的地方本科院校体育教育专业人才培养模式研究

通过对普通高校体育教育专业人才培养模式现状分析,提出了以台州学院体育科学学院为个案的人才培养改革思路,从人才培养目标和规格、培养途径、课程设置、师资队伍、学生就业等方面对体育教育专业人才培养问题进行思考。     

Preparation of a novel biodegradable β-cyclodextrin-containing polymer

A novel cyclodextrin-containing polymer was prepared by graftingβ-cyclodextrin onto the backbone of poly(D,L-lactic acid)(PLA).First,mono(6-(2-aminoethyl)amino-6-deoxy)-β-cyclodextrin(β-CD-6-en)was prepared by sulfonylation and amination ofβ-cyclodextrin and modified poly(D,L-lactic acid)(MPLA)was prepared by free radical polymerization of maleic anhydride and PLA.Then,grafting ofβ-cyclodextrin derivative to MPLA backbone was carried out by N-acylation reaction of MPLA andβ-CD-6-en in dimethyl formamide.The...     

“胭脂山衣坊”对特色商业街区品牌建设的启发

胭脂山衣坊在建设中注意全面实施品牌建设,取得了较好发展。本文通过对特色商业街区的品牌建设问题的讨论,对胭脂山衣坊品牌建设的经验进行了归纳,并提出了建议。     

对流扩散问题的高阶交替方向并行算法

将区域分解技术与紧交替方向隐格式相结合,对二维对流扩散问题提出了一种新的并行算法(该算法对工程中规模较大的问题尤为适用),给出了收敛性结论,并用数值实例验证了算法的可行性.     

苦参碱抗肿瘤作用机制研究进展

苦参碱的抗肿瘤机制较为广泛,包括抑制端粒酶活性、抑制肿瘤细胞增殖、抑制肿瘤细胞转移和诱导肿瘤细胞凋亡等．近年来,对苦参碱抗肿瘤机制的研究又有了新进展,相关研究已经深入到分子和基因水平,本文对近年来苦参碱抗肿瘤作用机制研究方面取得的最新进展进行了综述,并对苦参碱抗肿瘤作用的研究方向进行了展望．     

教师培训管理有效性探析

教师培训管理的有效性关系到各种投入的效率和教师队伍整体素质的提升,当前存在有效性缺乏的主要原因是供需不对应、规划不系统、管理不科学和缺乏自主性等。教师培训有效性的评判应以参训教师满意、选派单位满意、培训主管部门满意和培训提供部门的满意度为评判标准,通过问卷调查和跟踪随访以及意见反馈等方式获得。提升有效性应当通过建立满意度反馈机制来创新管理模式、创新培训内容和创新培训形式实现。     

论学校惩戒权及其法律规制

惩戒是教育活动的内在要求和必要组成部分,也是学生受教育权利充分实现的可靠保障.学生的权利不是绝对的,学校惩戒不同于"体罚"或者"变相体罚",适度、合理的惩戒是维护正常教育教学秩序的必要手段.惩戒权作为立法赋予学校或教师的权力,是国家教育权的具体化,具有典型的公法特征.必须明确惩戒权作为教师职业性权力的性质和法律地位,同时通过实体性、程序性立法,明确规定惩戒权的内容、行使的程序以及违法行使惩戒权应承担的法律责任,同时规定学生必要的救济途径,在保障达成公共教育目标的同时,不侵害学生的合法权益.     

语境优选推导

基于优选论,建立语境推导模式,其中制约条件为句法缺省值原则、语义真实性原则和语用真实性原则.模式体现了直线推导、自动激活、同步激活、动态可及性四个特点,反映了推导过程中各步骤间的因果关系.     

Detection of plasmid-mediated IMP-1 metallo-β-lactamase and quinolone resistance determinants in an ertapenem-resistant Enterobacter cloacae isolate

Objective: To investigate the mechanism of carbapenem resistance and the occurrence of plasmid-mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in a clinical isolate of Enterobacter cloacae. Methods: An ertapenem-resistant E. cloacae ZY106, which was isolated from liquor puris of a female gastric cancer patient in a Chinese hospital, was investigated. Antibiotic susceptibilities were determined by agar dilution method. Conjugation experiments, isoelectric focusing, polymerase chain reaction (PCR), and DNA sequence analyses of plasmid-mediated carbapenemases and quinolone resistance determinants were preformed to confirm the genotype. Outer membrane proteins (OMPs) were examined by urea-sodium dodecyl sulfate-polyacrylamide gel electrophoresis (Urea-SDS-PAGE). Results: Minimum inhibitory concentrations (MCs) of imipenem, mer-openem, and ertapenem for ZY106 were 2,4, and 16 ug/ml, respectively. Conjugation studies with Escherichia coli resulted in the transfer of significantly reduced carbapenem susceptibility. ZY106 produced IMP-1 metallo-p-lactamase and CTX-M-3 extended-spectrum P-lactamase, and E. coli transconjugant produced IMP-1. Plasmid-mediated quinolone resistance determinant qnrSI was detected in ZY106. Transfer of the qnrSI-encoding-plasmid into E. coli by conjugation resulted in intermediate resistance to ciprofloxacin in E. coli transconjugant. Urea-SDS-PAGE analysis of OMPs showed that ZY106 lacked an OMP of approximately 38 KDa. Conclusion: It is the first IMP-1-producing Enterobacteriaceae in China and the first report of a clinical isolate that harbors both blaIMP and qnrS genes as well. The blaIMP-1, blaCTX-M-3, and qnrSl are encoded at three different plasmids. IMP-1 combined with the loss of an OMP possibly resulted in ertapenem resistance and reduced imipenem and mero-penem susceptibility in E. cloacae.