A microfluidic membrane device to mimic critical components of the vascular microenvironment

Vascular function, homeostasis, and pathological development are regulated by the endothelial cells that line blood vessels. Endothelial function is influenced by the integrated effects of multiple factors, including hemodynamic conditions, soluble and insoluble biochemical signals, and interactions with other cell types. Here, we present a membrane microfluidic device that recapitulates key components of the vascular microenvironment, including hemodynamic shear stress, circulating cytokines, extracellular matrix proteins, and multiple interacting cells. The utility of the device was demonstrated by measuring monocyte adhesion to and transmigration through a porcine aortic endothelial cell monolayer. Endothelial cells grown in the membrane microchannels and subjected to 20 dynes∕cm(2) shear stress remained viable, attached, and confluent for several days. Consistent with the data from macroscale systems, 25 ng∕ml tumor necrosis factor (TNF)-α significantly increased RAW264.7 monocyte adhesion. Preconditioning endothelial cells for 24 h under static or 20 dynes∕cm(2) shear stress conditions did not influence TNF-α-induced monocyte attachment. In contrast, simultaneous application of TNF-α and 20 dynes∕cm(2) shear stress caused increased monocyte adhesion compared with endothelial cells treated with TNF-α under static conditions. THP-1 monocytic cells migrated across an activated endothelium, with increased diapedesis in response to monocyte chemoattractant protein (MCP)-1 in the lower channel of the device. This microfluidic platform can be used to study complex cell-matrix and cell-cell interactions in environments that mimic those in native and tissue engineered blood vessels, and offers the potential for parallelization and increased throughput over conventional macroscale systems.     

On the Rational Solution of Dominant Issues in Higher Education

As universities and colleges have changed, so has the role of faculty. Greater accountability is expected for faculty time and effort. This paper considers faculty roles by the institution preparing new faculty, the institution hiring new faculty, and the new faculty member themselves. All institutions are seeking faculty who are triple threats: integrate discovery, learning, and engagement; increase and maintain knowledge and technology; and involve students in their professional lives. Institutions preparing new faculty must develop models that stress not only quality research, but address the balance of faculty roles. Hiring institutions must select new faculty so that interest and balance match institutional goals. New faculty must understand what they want from academic life and seek appropriate institutions.     

A Conceptual Framework for Assessment Literacy: Opportunities for Physical Education Teacher Education

ABSTRACT

Although more nuanced understandings of assessment have been proposed in the physical education literature, assessment practices remain relatively underdeveloped, and when used, tend to focus on traditional, summative evaluations of learning. However, physical education teacher education programs can be used as an intervention to help pre-service teachers develop assessment knowledge and skill. Toward this end, the purpose of this article is to propose an evidence-based framework for helping pre-service teachers develop assessment literacy that is rooted in occupational socialization theory. The framework provides a four-phase approach to integrating assessment into teacher education, and includes suggestions for how physical education teacher educators can progressively help build pre-service teachers’ assessment knowledge in line with the focus given to instruction and planning. These suggestions acknowledge the technical and sociocultural aspects of learning to use assessment. Implications are discussed along with the need to help graduating pre-service teachers transfer lessons learned into the workplace.     

Contextualising higher education assessment task words with an ‘anti-glossary’ approach

Key ‘generic’ assessment task words such as ‘discuss’ and ‘critically evaluate’ are integral to higher education assessment. Although sources such as study skills guides give generic decontextualised glossaries of these words, much research rightly argues for greater dialogue between students (particularly ‘non-traditional’ students) and lecturers to help students understand and use such words. This paper presents the results from ‘staged’ focus groups with lecturers and students from the UK and China that created a forum for such dialogue, where many of these words and their interpretations were talked about. Results show very different interpretations, informed by factors such as ‘language’, ‘culture’ and ‘subject’. We propose these factors be used in an ‘anti-glossary’ approach, which we describe here. This approach is not against glossaries per se, but counteracts the assumption that glossary definitions are explicit, and adopts a social constructivist contextualisation of the task words through teacher-led dialogue.     

Orthographic Depth and Spelling Acquisition in Estonian and English: A Comparison of Two Diverse Alphabetic Languages

In this study, we investigated the link between the orthographic transparency of a language and the ease or difficulty of acquiring spelling proficiency in that language. The two languages compared are English, with a highly irregular sound-to-print correspondence, and Estonian, a Finno-Ugric language that has one of the most highly regular sound-to-print matches among alphabetic languages. Our study finds Estonian students able to use their early knowledge of stable letter-sound correspondence to attain a high level of spelling proficiency as early as first grade. English students progress more slowly along a predictable pattern of acquiring proficiency based on increasingly more difficult word features. The final indication is that progress in spelling is highly dependent on the orthographic depth of the language being studied.     

'The centre cannot hold': complexity and difference in European Union policy towards a learning society

The notions of lifelong learning and a learning society have been an important policy driver in the European Union at both the Commission and national government levels for a number of years. Overall, these policies aim to promote the twin goals of competitiveness in international markets and social cohesion within the still-expanding borders of the Union itself. To date, however, the impact of this emphasis on lifelong learning has been relatively slight. This article argues that this is in part because the policy process in relation to the development of a learning society is based on a view of governance and power that is open to reasoned dispute, and is, therefore, bound to disappoint in relation to its espoused goals. It is suggested that, rather than implementation being the main ‘problem’ of policy, the policy context inevitably generates many recontextualizations and renegotiations of meanings according to the situations and the actors involved, thereby undermining the notion of ‘implementation’ as a technical-rational process. It is argued that the complex negotiations enacted at local level reveal and are fashioned by tensions between the membership resources available to actors. This emphasizes complexity, diversity, and difference in policy processes, bringing to the fore a communicative and distributed approach to policy rather than one that is technical and centralizing.     

Educational inequality in English primary education

This paper summarises some English research findings related to educational inequality, particularly in inner urban schools. It documents how differences related to relative poverty are reflected in patterns of educational attainment as revealed by national tests results. It considers and evaluates how the issue of educational inequality in England has been tackled.     

Reviewers

Abstract

The growth in importance of performance assessment in education over recent years has been linked with a concern to ensure that the service represents ‘value for money’. To date the absence of a satisfactory analytical framework has meant that questions of ‘effectiveness’ and ‘efficiency’ have been kept separate. An additional problem has been that, whilst there are many different outcomes which are appropriate for education authorities to pursue, conventional models handle these only one at a time.

In this paper we use data on the 96 English LEAs to show how an underlying model allows authorities to be compared in terms of ‘efficiency’ when facing different environmental circumstances and utilising different resource inputs. The technique of Data Envelopment Analysis (DEA) is first described in the context of an explanatory model, and then the results of applying this to the English LEAs are presented.

As distinct from a league table’ analysis, DEA gives some indications of where improvements are to be sought. It allows for ‘trade‐offs’ between outputs of different types and provides a small but distinct peer group of ‘efficient’ authorities to which an ‘inefficient’ LEA can be compared.

The efficiency measure used is ‘relative efficiency’ which arises from comparing the actual performance of an inefficient authority with that of others which can be used to model its environmental circumstances and resource inputs.

A number of case studies are described. The limitations of the technique, and the caution required in interpretation, are discussed.     

Academics' perceptions of their professional development needs related to leadership and management: What can we learn?

Enquiries into the governance, structure and management of higher education institutions across the globe have stimulated changes to the legislative and policy frameworks within which universities operate and to their organizational structures and processes. These changes have subsequently brought into question the proper role of academics in relation to the leadership and management of their departments/institutions. While mainstream academic staff conceive of academic leadership as being strictly associated with teaching, research and community outreach, university administrators and policy makers conceptualize it more broadly. Their definitions often include the management of change, quality, information, finance, and physical and human resources - functions that many mainstream academics perceive as being the responsibility of departmental/institutional administrative or support staff. Such differences create major challenges for academic development units. What type of training should they provide? Should they embrace activities that support these new conceptions of leadership and management? These are among the central issues explored in this paper.