Touch your toes! Developing a direct measure of behavioral regulation in early childhood

Behavioral aspects of self-regulation, including controlling and directing actions, paying attention, and remembering instructions, are critical for successful functioning in preschool and elementary school. In recent years, several direct assessments of these skills have appeared, but few studies provide complete psychometric data and many are not easy to administer. We developed a direct measure of children's behavioral regulation, the Head-to-Toes Task, and report performance of participants aged 36–78 months, including a group of Spanish-speaking children, from two different sites (N = 353; N = 92). We examined construct validity, examiner reliability, sources of variation, and associations between task scores and background characteristics. Results showed that the task was valid, reliable, and demonstrated variability in children's scores. A cross-classified hierarchical growth curve analysis indicated that girls, participants assessed in English, and higher-socioeconomic status (SES) children achieved slightly higher average scores than did boys, Spanish-speaking and lower-SES children, but effect sizes were small. Older participants achieved higher scores than did younger children, and there were no effects for site. Results suggest that the Head-to-Toes Task is an informative and easy-to-administer direct assessment of children's behavioral regulation. We discuss implications for its use in early childhood settings.     

Quantum pharmacology

Quantum chemistry is based on the solution of the Schrödinger equation for a molecule. From starting data on the positions and nature of constituent atoms information is provided about the energy of the molecule and its electronic properties. The former can indicate what shapes drugs can adopt in binding to pharmacological receptors whilst electronic details, when compared using computer graphics, may highlight the factors responsible for biological activity. These techniques are beginning to show real successes in the design of drug molecules.     

Heart Rate and Behavioral measures of Attention in Six-, Nine-, and Twelve-Month-Old Infants during Object Exploration

In this study we examined the effect of heart rate and behavioral measures of attention on distractibility of 6-, 9-, and 12-month-old infants. The infants were presented with a toy, and a distractor was presented while they attended to the toy. The distractor was presented during heart rate changes indicating sustained attention or attention termination, or during periods of time when behavioral ratings indicated the infant was in focused or casual attention. There were longer distraction latencies during attentional engagement as defined by heart rate changes or behavioral ratings than for periods of inattention. Infants had the longest distraction latencies when heart rate and behavior measures were congruent with respect to attention engagement (heart rate deceleration and focused attention). Conversely, latencies were shortes for congruent values of inattention (heart rate acceleration and casual attention). Infant information processing may be greatest when a heart rate deceleration occurs simultaneously with an episode of focused attention.