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71.
Karthiga Panneerselvam Martin E. Lynge Camilla Frich Riber Sofia Mena-Hernando Anton A. A. Smith Kenneth N. Goldie Alexander N. Zelikin Brigitte St?dler 《Biomicrofluidics》2015,9(5)
Recently, the combination of lipids and block copolymers has become an alternative to liposomes and polymersomes as nano-sized drug carriers. We synthesize novel block copolymers consisting of poly(cholesteryl acrylate) as the hydrophobic core and poly(N-isopropylacrylamide) (PNIPAAm) as the hydrophilic extensions. Their successful phospholipid-assisted assembly into vesicles is demonstrated using the evaporation-hydration method. The preserved thermo-responsive property of the lipid-polymer hybrids is shown by a temperature dependent adsorption behaviour of the vesicles to poly(l lysine) coated surfaces. As expected, the vesicle adsorption is found to be higher at elevated temperatures. The cellular uptake efficiency of hybrids is assessed using macrophages with applied shear stress. The amount of adhering macrophages is affected by the time and level of applied shear stress. Further, it is found that shorter PNIPAAm extensions lead to higher uptake of the assemblies by the macrophages with applied shear stress. No inherent cytotoxicity is observed at the tested conditions. Taken together, this first example of responsive lipid-polymer hybrids, and their positive biological evaluation makes them promising nano-sized drug carrier candidates. 相似文献
72.
Educational Studies in Mathematics - In this article, we direct attention to what becomes critical in teaching activities for toddlers (1–3-year-olds) to learn the meaning of numbers. One... 相似文献
73.
Emily McDougal Priya Silverstein Oscar Treleaven Lewis Jerrom Katie A. Gilligan-Lee Camilla Gilmore Emily K. Farran 《Child development》2023,94(5):1381-1397
There is a known association between LEGO® construction ability and mathematics achievement, yet the mechanisms which drive this association are largely unknown. This study investigated the spatial mechanisms underlying this association, and whether this differs for concrete versus digital construction. Between January 2020 and July 2021, children aged 7–9 years (N = 358, 189 female, ethnicity not recorded) completed spatial and mathematics tasks, and either a concrete or digital Lego construction task. Mediation analyses examining direct and indirect pathways (through spatial skills) between Lego construction ability and mathematics explained 8.4% to 26.6% of variance in mathematics scores. Exploratory moderated mediation analyses revealed that only the indirect path through mental rotation differed between Lego conditions. Findings are discussed in relation to theories of spatial-numerical associations and the potential of Lego training for mathematics improvement. 相似文献
74.
The experience of interest is central to intrinsic motivation for learning, so it is important to understand the nature of interest and its sources. Individual differences in fluid intelligence (Gf) predict finding things more interesting, but it is possible that this effect is merely due to the overlap of Gf with openness to experience, a strong predictor of interest across many domains. The present research measured Gf, the Big Five traits, and the interestingness of contemporary poems and visual art. Latent variable models found that Gf predicted interest in both poems and pictures, even when openness and gender were included as predictors. Moreover, Gf and openness did not interact, indicating main effects rather than joint effects. The relationship between Gf and interest thus appears robust. 相似文献
75.
Megan Foulkes Francesco Sella Theresa Elise Wege Camilla Gilmore 《Mind, Brain, and Education》2023,17(3):185-196
There is mixed evidence as to whether concrete manipulatives (e.g., toy animals) are better than abstract manipulatives (e.g., counters) for teaching mathematical concepts to children. Concreteness is defined as the amount of extraneous information a manipulative provides, and in this study we aimed to unpick which dimensions of concreteness influence manipulative choice. Researchers, teachers, and parents completed a comparative judgment task comparing images of manipulatives varying in different dimensions of concreteness, selecting which they would choose to teach arithmetic to children. The findings indicated homogeneous, 3-dimensional manipulatives were the most preferred across all groups to teach arithmetic to children, regardless of more extraneous features. This contradicts research recommendations to minimize the use of concrete manipulatives due to their distractive qualities. Instead, it suggests that some concrete features may be preferred in more naturalistic contexts. More research is required to investigate how different dimensions of concreteness influence learning outcomes for children both in artificial research contexts and in practice. 相似文献