Floating-electrode enhanced constriction dielectrophoresis for biomolecular trapping in physiological media of high conductivity

We present an electrokinetic framework for designing insulator constriction-based dielectrophoresis devices with enhanced ability to trap nanoscale biomolecules in physiological media of high conductivity, through coupling short-range dielectrophoresis forces with long-range electrothermal flow. While a 500-fold constriction enables field focusing sufficient to trap nanoscale biomolecules by dielectrophoresis, the extent of this high-field region is enhanced through coupling the constriction to an electrically floating sensor electrode at the constriction floor. However, the enhanced localized fields due to the constriction and enhanced current within saline media of high conductivity (1 S/m) cause a rise in temperature due to Joule heating, resulting in a hotspot region midway within the channel depth at the constriction center, with temperatures of ∼8°–10°K above the ambient. While the resulting vortices from electrothermal flow are directed away from the hotspot region to oppose dielectrophoretic trapping, they also cause a downward and inward flow towards the electrode edges at the constriction floor. This assists biomolecular trapping at the sensor electrode through enabling long-range fluid sampling as well as through localized stirring by fluid circulation in its vicinity.     

Isokinetic hamstrings-to-quadriceps peak torque ratio: the influence of sport modality, gender, and angular velocity

The purpose of this study was to determine differences in hamstrings-to-quadriceps (H/Q) peak torque ratios evaluated at different angular velocities between men and women who participate in judo, handball or soccer. A total of 166 athletes, including 58 judokas (26 females and 32 males), 39 handball players (22 females and 17 males), and 69 soccer players (17 females and 52 males), were evaluated using an isokinetic dynamometer. The H/Q isokinetic peak torque ratios were calculated at angular velocities of 1.05 rad · s?1 and 5.23 rad · s?1. In the analysis by gender, female soccer players produced lower H/Q peak torque ratios at 1.05 rad · s?1 than males involved in the same sport. However, when H/Q peak torque ratio was assessed at 5.23 rad · s?1, there were no significant differences between the sexes. In the analysis by sport, there were no differences among females at 1.05 rad · s?1. In contrast, male soccer players had significantly higher H/Q peak torque ratios than judokas (66 ± 12% vs. 57 ± 14%, respectively). Female handball players produced significantly lower peak torque ratios at 5.23 rad · s?1 than judokas or soccer players, whereas males presented no ratio differences among sports At 5.23 rad · s?1. In the analysis by velocity, women's muscular ratios assessed at 1.05 rad · s?1 were significantly lower than at 5.23 rad · s?1 for all sports; among men, only judokas presented lower ratios at 1.05 rad · s?1 than at 5.23 rad · s?1. The present results suggest that sport modality and angular velocity influence the isokinetic strength profiles of men and women.     

Effects of replica running shoes upon external forces and muscle activity during running

Twelve participants ran (9 km · h(-1)) to test two types of running shoes: replica and original shoes. Ground reaction force, plantar pressure and electromyographic activity were recorded. The shoes were tested randomly and on different days. Comparisons between the two experimental conditions were made by analysis of variance (ANOVA) test (P ≤ 0.05). The time to first peak, loading rate of the first peak and impulse of the first 75 ms of stance were significantly different between the shoes (P ≤ 0.05), revealing an increase of impact forces for the replica shoes. The peak plantar pressure values were significantly higher (P ≤ 0.05) when wearing replica shoes. During running, the contact area was significantly smaller (P ≤ 0.05) for the replica shoe. The electromyographic activity of the analysed muscles did not show changes between the two shoes in running. These findings suggest that the use of replica running shoes can increase the external load applied to the human body, but may not change the muscle activity pattern during locomotion. This new mechanical situation may increase the risk of injuries in these movements.     

Evaluation of two interventions to reduce aggressive and antisocial behavior in first and second graders in a resource-poor setting

We conducted a three-arm cluster randomized controlled trial (n = 2491) to evaluate a teacher delivered intervention to reduce aggressive and antisocial behavior and increase prosocial behavior in the classroom. A second aim of this trial was to establish whether combining this intervention with an intervention for parents was better than the teacher-only intervention. This evaluation was conducted in a resource-poor setting (Pereira, Colombia). The findings show that both interventions prevented increases in aggressive and antisocial behavior. However, the teacher-only intervention also had a positive impact on increasing prosocial behavior.     

形成性评价（Formative Assessment）的本质及其对教与学的影响

长期以来,很多学者一直倡导指导教学的评价,即通过评估学生需求和监测其学习进展,适当地设计学习顺序,调整教学策略,改良学习计划,以便有效地促进学习目标的完成。本研究调查了形成性评价在美国中学科学课中的实施情况,并分析其对学生学习进步的影响。研究表明,教师都在努力使用形成性评价来指导教学,而学生取得的成绩各不相同。     

Widely linear estimation for multisensor quaternion systems with mixed uncertainties in the observations

The optimal widely linear state estimation problem for quaternion systems with multiple sensors and mixed uncertainties in the observations is solved in a unified framework. For that, we devise a unified model to describe the mixed uncertainties of sensor delays, packet dropouts and uncertain observations by using three Bernoulli distributed quaternion random processes. The proposed model is valid for linear discrete-time quaternion stochastic systems measured by multiple sensors and it allows us to provide filtering, prediction and smoothing algorithms for estimating the quaternion state through a widely linear processing. Simulation results are employed to show the superior performance of such algorithms in comparison to standard widely linear methods when mixed uncertainties are present in the observations.