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81.
Microfluidic devices allow for the production of physiologically relevant cellular microenvironments by including biomimetic hydrogels and generating controlled chemical gradients. During transport, the biomolecules interact in distinct ways with the fibrillar networks: as purely diffusive factors in the soluble fluid or bound to the matrix proteins. These two main mechanisms may regulate distinct cell responses in order to guide their directional migration: caused by the substrate-bound chemoattractant gradient (haptotaxis) or by the gradient established within the soluble fluid (chemotaxis). In this work 3D diffusion experiments, in combination with ELISA assays, are performed using microfluidic platforms in order to quantify the distribution of PDGF-BB and TGF-β1 across collagen and fibrin gels. Furthermore, to gain a deeper understanding of the fundamental processes, the experiments are reproduced by computer simulations based on a reaction-diffusion transport model. This model yields an accurate prediction of the experimental results, confirming that diffusion and binding phenomena are established within the microdevice. 相似文献
82.
Marc F. Moreira Jorge E. Morais Daniel A. Marinho António J. Silva Tiago M. Barbosa 《Sports biomechanics / International Society of Biomechanics in Sports》2014,13(1):62-74
This study aimed to analyse the effect of growth during a summer break on biomechanical profile of talented swimmers. Twenty-five young swimmers (12 boys and 13 girls) undertook several anthropometric and biomechanical tests at the end of the 2011–2012 season (pre-test) and 10 weeks later at the beginning of the 2012–2013 season (post-test). Height, arm span, hand surface area, and foot surface area were collected as anthropometric parameters, while stroke frequency, stroke length, stroke index, propelling efficiency, active drag, and active drag coefficient were considered as biomechanical variables. The mean swimming velocity during an all-out 25 m front crawl effort was used as the performance outcome. After the 10-week break, the swimmers were taller with an increased arm span, hand, and foot areas. Increases in stroke length, stroke index, propelling efficiency, and performance were also observed. Conversely, the stroke frequency, active drag, and drag coefficient remained unchanged. When controlling the effect of growth, no significant variation was determined on the biomechanical variables. The performance presented high associations with biomechanical and anthropometric parameters at pre-test and post-test, respectively. The results show that young talented swimmers still present biomechanical improvements after a 10-week break, which are mainly explained by their normal growth. 相似文献
83.
Javier Noya Salces Pedro M. Gómez-Carmona Diego Moliner-Urdiales Manuel Sillero-Quintana 《Journal of sports sciences》2014,32(13):1263-1270
AbstractThe aim was to examine the injuries sustained by Spanish football players in the First Division and to compare injury-related variables in the context of both competition and training. The injury data were prospectively collected from 16 teams (427 players) using a specific web-based survey during the 2008/2009 season. A total of 1293 injuries were identified (145 were recurring injuries). The overall injury incidence was 5.65 injuries per 1000 h of exposure. Injuries were much more common during competition than during training (43.53 vs. 3.55 injuries per 1000 h of exposure, P < 0.05). Most of the injuries (89.6%) involved the lower extremities, and overuse (65.7%) was the main cause. Muscle and tendon injuries were the most common types of injury (53.8%) among the players. The incidence of training injuries was greater during the pre-season and tended to decrease throughout the season, while the incidence of competition injuries increased throughout the season (all P < 0.05). In conclusion, the results of this study suggest the need for injury prevention protocols in the First Division of the Spanish Football League to reduce the number of overuse injuries in the muscles and tendons in the lower extremities. In addition, special attention should be paid during the pre-season and the competitive phase II (the last four months of the season) in order to prevent training and competition injuries, respectively. 相似文献
84.
CarloS. Furió RafaeL. Azcona Jenaro Guisasola Mary Ratcliffe 《International Journal of Science Education》2013,35(12):1285-1304
In this study the origin and evolution of the meanings of the concepts 'amount of substance' and 'mole' are described. Serious disagreements about these concepts amongst chemistry teachers and the recommendations of the international scientific community are identified. Attention is also drawn to the didactic implications that these epistemological difficulties may have for the teaching of chemistry. 相似文献
85.
Manuel Perea Victoria Panadero Carmen Moret-Tatay Pablo Gómez 《Learning and Instruction》2012,22(6):420-430
Recent research has demonstrated that slight increases of inter-letter spacing have a positive impact on skilled readers' recognition of visually presented words. In the present study, we examined whether this effect generalises to young normal readers and readers with developmental dyslexia, and whether increased inter-letter spacing affects the reading times and comprehension of a short text. To that end, we conducted a series of lexical decision and continuous reading experiments in which words were presented with the default settings or with a small increase in inter-letter spacing. Increased spacing produced shorter word identification times not only with adult skilled readers (Experiment 1), but also with young normal readers (Grade 2 and Grade 4 children; Experiment 2) and, even to a larger degree, with readers with dyslexia (Experiments 3 and 4). These experiments suggest that slight increases in inter-letter spacing would improve the readability of texts aimed at children, especially those with dyslexia. 相似文献
86.
Andrea Conchado Peiró Khaled M. Gharaibeh Hazem Kaylani 《European Journal of Engineering Education》2017,42(5):547-560
The objective of this study is to identify the competencies required to achieve success in the transition from higher education to the labour market based on the perceptions of employers. This paper analyses the assessments made by a group of engineering company employers. An item-battery of 20 competencies was grouped into 3 dimensions by using factor analysis. Subsequently, respondents’ scores were also clustered into three groups and characterised through contingency tables. The competencies demanded by employers were grouped into business and finance, problem-solving and strategic planning. Significant differences were found between responses from employers working in medium and small companies, who placed more importance on competencies related to problem-solving and strategic planning, and employers in big companies, who were more concerned about the difficulties of finding well-trained graduates. The findings from this paper have important implications for research in the areas of higher education and organisations that usually employ graduate engineers. 相似文献
87.
The aim of this article is to analyse whether having experience of formative assessment during their initial teacher education courses (ITE) influences graduates’ subsequent practice as teachers. That is, if the assessment methods that university students are subject to during their learning process are then actually employed by them during their professional practice as schoolteachers. To address this issue, questionnaires were issued and focus groups were held with a sample of ITE graduates. The main results of the study are that: (1) formative and shared assessment (FSA) is not used a great deal during ITE, but is highly valued; (2) some graduates have implemented FSA in their practice as teachers, following their experience on their ITE course; and (3) significant variables are found regarding the implementation of FSA in schools (possible resistance from colleagues and/or pupils’ parents, etc.). 相似文献
88.
Filomena Critelli Laura Lewis Adalberto Méndez-López 《Journal of Teaching in Social Work》2017,37(2):121-137
This article examines an innovative model of online international education regarding disability through a human rights perspective piloted through a collaboration between Universidad LaSalle, Mexico, and University at Buffalo, United States. The course is organized around a pressing global human rights and development issue. Its objective is to promote effective practice with persons with disabilities through cross-national, cross-disciplinary, human-rights based education; strengthen students’ sense of global engagement; and foster cross-cultural expertise and competence with diversity. The implications for effective professional education in law and social work are discussed. The article also examines pedagogical strategies and presents case study materials, identifies key disability rights themes common to both nations and cultures, and explores how distance learning technology is implemented in the course. A preliminary assessment of this newly piloted approach is also presented, based on data from students, as well as the implications for teaching and practice. 相似文献
89.
90.
This work is devoted to the study of symmetric control systems. It establishes a relation between internal symmetry and external one for a linear invariant control system having n real simple poles. The symmetric stabilization problem is studied using a symmetric feedback gain such that the output control stabilizes the closed-loop system. A necessary and sufficient condition is given to solve this stabilization problem for a symmetric control system (A,B,C) and a generalized symmetric control system (E,A,B,C). 相似文献