Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy

Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia (AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor (G-CSF) (low-dose chemotherapy (LDC)/G-CSF). Complete response (CR) after two induction courses was attained in 87.0% (40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy (SDC) for induction (80/94 (85.1%) of the patients attained CR after induction II, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free (67.4 vs. 70.7%; P = 0.99) and overall (70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell (WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC (11.5 vs. 18.5 d for WBCs (P < 0.001); 15.5 vs. 22.0 d for platelets (P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF (n = 9) or SDC (n = 11), all of the mutations were below the reference value (variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML.     

日本国立大学法人化改革效果分析——以名古屋大学为例

截至2006年,日本国立大学法人化改革已经进行了两年。根据国立大学法人调查委员会的解释,实施日本国立大学法人制度有三个目的：一是创建富有个性的大学和开展具有国际竞争力的教育研究；二是强化国立大学对国民和社会的责任,并在高校贯彻落实竞争原理；三是实现经营责任明确化,并使大学的经营活动具有灵活性和战略性。简言之,希望通过此次法人化改革,在提高大学自主性和自律性的基础上,提高大学的管理水平,最终提高国立大学教育和研究质量、充分发挥国立大学使命。     

新疆少数民族贫困地区农村学校校本课程开发的几点思考——以和田地区墨玉县托乎拉乡初中校本课程开发为例

通过对新疆和田地区典型的贫困维吾尔族聚居村——墨玉县托乎拉乡初中的校本课程开发状况的调查研究，分析了南疆少数民族贫困地区农村基础教育阶段校本课程开发的现状及成因，阐释了校本课程开发要立足于当地社会经济文化发展需要和少数民族学生身心发展规律。     

What It Takes: Promising Practices for Immigrant Origin Adolescent Newcomers

Using a multiple case study approach across seven schools in the United States and Sweden that serve newcomer students exceptionally well, we identified the strategies they implemented across sites that served to meet the educational needs of these students. We found that these schools provided a comprehensive approach to support the socioemotional and academic needs of their newcomer students, identifying many common practices for improving outcomes for newcomer students.     

内外部社会资本对知识创造作用的实证研究

建立组织内部社会资本、外部社会资本和知识创造之间的理论模型,并以山东省698家企业为对象运用结构方程模型进行实证研究,并得出结论,内部社会资本对知识创造有正向的影响,外部社会资本对知识创造有正向的影响,内部社会资本与外部社会资本之间存在相互关联关系,为企业通过提高内部和外部社会资本提升知识创造能力提供理论基础和实践参考.     

Backstage accounting in preschool: analysing dealing with complaints as ‘rehearsing away’ professional knowledge

Citizens of modern societies must trust a broad range of systems and professionals. When distrust arises, professionals are expected to be accountable. This paper draws on conversational material from a preschool team meeting. When a preschool work team prepares to meet a parent who has complained about their recurring neglect to change her child’s nappies ‘in time’, they are found: (1) to carefully review the encounter with the client, (2) in a team-building fashion, to select suitable accounts to offer ‘front stage’ and (3) to internally justify their selection of accounts. Our results indicate that work team members who engaged in backstage rehearsal author the organisation for building trust and, simultaneously ‘rehearse away’ what should remain the organisations’ secrets. Communicating the intent to satisfy was deemed more important than was using evidence from their professional knowledge base.     

浅谈"以人为本"与高校图书馆

本文阐述了以人为本管理思想和服务理念的基本内涵及其在高校图书馆管理,创新中的重要作用和现实意义。     

基于统计分析的教学质量的分析评价──以高等数学教学为例

本文以试卷库和问卷调查为基础应用统计分析的方法考察试卷库质量并研究影响教学质量的因素,以期了解到学生对各章节内容的掌握和得分情况,找到影响教学质量的主要因素,并以此分析学生的学习状态和学习质量。这将有助于教师对学生学习过程的了解和把握,也有助于提高自身的教学能力,为进一步提高教学质量提供定性与定量分析的理论依据。     

高校图书馆数字资源整合及其实现

论述了数字资源整合的意义,分析了高校图书馆数字资源整合的主要方式和常用技术。