单纤维对训练的适应

随着特殊的训练计划被教练员们采用以促进运动员的肌肉适应能力,肌肉训练也成为渐进式康复的重要组成部分,它能阻止与丧失运动能力、老化、疾病或微重力相关的萎缩效应。为了优化不同类型的干扰措施,需要更好地理解运动训练产生的反应,以及识别决定肌肉功能的各种机制。虽然整体肌肉活动在某种程度上是通过适应运动神经元爆发、运动单元补充模式或者肌肉量来进行的,本研究着重探讨肌肉纤维类型的表达以及训练后收缩肌的功能性适应能力。单一无皮纤维被证明是常用的实验模型,用于研究与肌浆球蛋白重链对碘氧基苯甲醚相关的试管内收缩特性。人体纤维主要的功能和生化特性在过去二十年中已经被详细研究了,但近来,无皮纤维模式正被用于研究不同类型的诱发训练后单纤维的功能适应性。本文的目的是概述收缩肌对于特定运动训练计划的反应,以及帮助形成适用于运动科学和康复的训练计划。     

A tapered channel microfluidic device for comprehensive cell adhesion analysis, using measurements of detachment kinetics and shear stress-dependent motion

We have developed a method for studying cellular adhesion by using a custom-designed microfluidic device with parallel non-connected tapered channels. The design enables investigation of cellular responses to a large range of shear stress (ratio of 25) with a single input flow-rate. For each shear stress, a large number of cells are analyzed (500–1500 cells), providing statistically relevant data within a single experiment. Besides adhesion strength measurements, the microsystem presented in this paper enables in-depth analysis of cell detachment kinetics by real-time videomicroscopy. It offers the possibility to analyze adhesion-associated processes, such as migration or cell shape change, within the same experiment. To show the versatility of our device, we examined quantitatively cell adhesion by analyzing kinetics, adhesive strength and migration behaviour or cell shape modifications of the unicellular model cell organism Dictyostelium discoideum at 21 °C and of the human breast cancer cell line MDA-MB-231 at 37 °C. For both cell types, we found that the threshold stresses, which are necessary to detach the cells, follow lognormal distributions, and that the detachment process follows first order kinetics. In addition, for particular conditions’ cells are found to exhibit similar adhesion threshold stresses, but very different detachment kinetics, revealing the importance of dynamics analysis to fully describe cell adhesion. With its rapid implementation and potential for parallel sample processing, such microsystem offers a highly controllable platform for exploring cell adhesion characteristics in a large set of environmental conditions and cell types, and could have wide applications across cell biology, tissue engineering, and cell screening.     

Active relatives and health-related physical fitness in European adolescents: The HELENA Study

Abstract High physical fitness in childhood and adolescence is positively associated with favourable health-related outcomes. Our aim was to examine the relationship between relatives' (father, mother, brother, sister, and best friend) physical activity engagement and encouragement on adolescents' physical fitness. Adolescents were part of the HELENA study, a multi-centre study conducted in 10 cities from nine European countries in 2006-2008. Participants were 3288 adolescents (48% boys, 52% girls) aged 12.5-17.5 years with valid data on at least one of the three fitness variables studied: muscular strength (standing long jump), speed/agility (4×10 m shuttle run), and cardiorespiratory fitness (20 m shuttle run). The adolescents reported their relatives' physical activity engagement and encouragement. Analysis of covariance showed that relatives' physical activity engagement (father, mother, brother, and best friend) was positively related to cardiorespiratory fitness (P?相似文献   

Recognizing the face of Johnny, Suzy, and me: insensitivity to the spacing among features at 4 years of age

Four-year-olds were tested for their ability to use differences in the spacing among features to recognize familiar faces. They were given a storybook depicting multiple views of 2 children. They returned to the laboratory 2 weeks later and used a "magic wand" to play a computer game that tested their ability to recognize the familiarized faces and their own face based on the spacing of features. Children performed at chance levels. Follow-up studies confirmed that they had attended to internal facial features and validated the stimuli. The results contrast with studies showing some sensitivity to the spacing of features in infants and preschool children; multiple mechanisms of face processing may make use of spatial relations and develop at different rates.     

Population policies and education: exploring the contradictions of neo‐liberal globalisation

The world is increasingly characterised by profound income, health and social inequalities (Appadurai, 2000 Appadurai, A. 2000. Grassroots globalisation and the research imagination. Public Culture, 12(1): 1–19. [Crossref], [Web of Science ®] [Google Scholar]). In recent decades development initiatives aimed at reducing these inequalities have been situated in a context of increasing globalisation with a dominant neo‐liberal economic orthodoxy. This paper argues that neo‐liberal globalisation contains inherent contradictions regarding choice and uniformity. This is illustrated in this paper through an exploration of the impact of neo‐liberal globalisation on population policies and programmes. The dominant neo‐liberal economic ideology that has influenced development over the last few decades has often led to alternative global visions being overlooked. Many current population and development debates are characterised by polarised arguments with strongly opposing aims and views. This raises the challenge of finding alternatives situated in more middle ground that both identify and promote the socially positive elements of neo‐liberalism and state intervention, but also to limit their worst excesses within the population field and more broadly. This paper concludes with a discussion outling the positive nature of middle ground and other possible alternatives.