Induction of diabetes by Streptozotocin in rats

The objective of this study is to induce experimental diabetes mellitus by Streptozotocin in normal adult Wistar rats via comparison of changes in body weight, consumption of food and water, volume of urine and levels of glucose, insulin and C-peptide in serum, between normal and diabetic rats. Intra-venous injection of 60mg/kg dose of Streptozotocin in adult wistar rats, makes pancreas swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes mellitus in the 2–4 days. Induction of experimental diabetes mellitus is indeed the first step in the plan of purification of pancreatic Langerhans islet cells of normal rats for transplanting under the testis subcutaneous of experimentally induced diabetic rats. Streptozotocin induces one type of diabetes which is similar to diabetes mellitus with non-ketosis hyperglycemia in some animal species. For induction of experimental diabetes in male adult rats weighted 250–300 grams (75–90 days), 60mg/kg of Streptozotocin was injected intravenously. Three days after degeneration of beta cells, diabetes was induced in all animals. The diabetic and normal animals were kept in the metabolic cages separately and their body weight, consumption of food and water, urine volume, the levels of serum glucose, insulin and C-peptide quantities in all animals were measured and then these quantities were compared. For a microscopic study of degeneration of Langerhans islet beta cells of diabetic rats, sampling from pancreas tissue of diabetic and normal rats, staining and comparison between them, were done. Induction of diabetes with Streptozotocin decreases Nicotinamide-adenine dinucleotide (NAD) in pancreas islet beta cells and causes histopathological effects in beta cells which probably intermediates induction of diabetes. In this study, we used Streptozotocin for our experiments in induction of experimental diabetes mellitus. After Induction of diabetes, consumption of food and water, volume of urine and glucose increased in the diabetic animals in comparison with normal animals, but the weight of body and the volume of insulin and C-peptide decreased in the diabetic animals. Sampling and staining of pancreas tissue of diabetic and normal rats showed that the Langerhans islet beta cells of diabetic rats have been clearly degenerated. In three days, Streptozotocin makes pancreas swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes. It also changes normal metabolism in diabetic rats in comparison with normal rats. Consumption of water and food, volume of urine, serum glucose increases in diabetic animals in comparison with normal rats but the levels of serum insulin, C-peptide and body weight decreases.     

To see or not to see: analyzing difficulties in geometry from the perspective of visual perception

In this paper, we consider theories about processes of visual perception and perception-based knowledge representation (VPR) in order to explain difficulties encountered in figural processing in junior high school geometry tasks. In order to analyze such difficulties, we take advantage of the following perspectives of VPR: (1) Perceptual organization: Gestalt principles, (2) recognition: bottom-up and top-down processing; and (3) representation of perception-based knowledge: verbal vs. pictorial representation, mental images and hierarchical structure of images. Examples given in the paper were mostly taken from Gal's study (2005) which aimed at identifying and analyzing Problematic Learning Situations (after Gal & Linchevski, 2000) in junior high school geometry classes. Gal's study (2005) suggests that while this theoretical perspective became part of teachers' pedagogic content knowledge, the teachers were aware of their students' thinking processes and their ability to analyze and cope with their students’ difficulties in geometry was improved.     

How Does the Degree of Guidance Support Students’ Metacognitive and Problem Solving Skills in Educational Robotics?

Educational robotics (ER) is an innovative learning tool that offers students opportunities to develop higher-order thinking skills. This study investigates the development of students’ metacognitive (MC) and problem-solving (PS) skills in the context of ER activities, implementing different modes of guidance in two student groups (11–12 years old, N1 = 30, and 15-16 years old, N2 = 22). The students of each age group were involved in an 18-h group-based activity after being randomly distributed in two conditions: “minimal” (with minimal MC and PS guidance) and “strong” (with strong MC and PS guidance). Evaluations were based on the Metacognitive Awareness Inventory measuring students’ metacognitive awareness and on a think-aloud protocol asking students to describe the process they would follow to solve a certain robot-programming task. The results suggest that (a) strong guidance in solving problems can have a positive impact on students’ MC and PS skills and (b) students reach eventually the same level of MC and PS skills development independently of their age and gender.     

边疆少数民族地区农村中小学教师胜任力研究——基于新疆伊宁县的调查分析

在边疆少数民族农村教育相对落后的地区,提高农村中小学教师胜任力问题值得关注.通过对当前新疆伊宁县农村中小学教师胜任力的调查分析,运用因子分析构建了包括个人特质、教学知识与技能、职业态度、关心学生、管理能力、政治素养等6个一级因子和24个二级因子的农村中小学教师胜任力模型,以期提升边疆农村中小学教师的胜任力.     

Exploring alternative approaches to methodology in educational research

The objective of this study is to provide in-service teachers an opportunity to become familiar with the controversial nature of progress in science (growth of knowledge) and its implications for research methodology in education. The study is based on 41 participants who had registered for a nine-week course on Methodology of Investigation in Education, as part of their Master’s degree program. The course is based on 20 readings drawing upon a history and philosophy of science perspective (positivism, constructivism, Popper, Kuhn, Lakatos) and its implications for educational research. Course activities included written reports, class room discussions based on participants’ presentations, and written exams. Based on the results obtained it was concluded that: (a) participants were able to understand the basic ideas of constructivist philosophy and its pedagogical implications; (b) the role of behavioural objectives in actual educational practice was questioned; (c) integration of qualitative and quantitative research methods was considered to be an alternative to the current debate about the replacement of one method by the other; (d) participants considered the dilemma of evaluating students based on what they have learned or what they should have learned, within the social constructivist framework and generally favoured the former; and (e) most of the participants were reluctant to accept constructivism as a form of positivism, a controversial thesis that is gaining support in the research literature. Given the importance of alternative approaches to growth and meaning of knowledge, it is important that teachers be aware of conflicting situations in the classroom that refer to: objectivity, scientific method, qualitative-quantitative methods, relationship between method and problem, evaluation, and a critical appreciation of constructivism.     

具有容错特性的反馈控制

考虑到最优反馈控制在部分执行器（传感器）失效时仍能使系统稳定运行的条件，给出了求解该总理的算法，并用实例作了说明。     

具有二次性能指标的最优输出反馈的一个必要条件

本文用矩阵的秩这个工具考察了有限维线性系统具有二次性能指标的最优输出反馈问题，得到了一个必要条件。特殊情形下，这一条件可以演化为最优输出反馈增益与观测矩阵的乘积即为状态反馈增益这个相当清晰的关系。