Validity and reliability of a low-cost dynamometer to assess maximal isometric strength of upper limb

Muscle imbalance and deficit are key parameters for guiding rehabilitation and sports sessions and avoiding injuries. However, the high cost and non-portable nature of most instruments employed for muscle strength assessment frequently hamper an affordable evaluation in field conditions. This study evaluated the validity and reliability of a low-cost digital dynamometer to assess the maximal isometric strength of upper limb muscles. Fourteen physically active volunteers performed the main movements of the upper limb at maximal isometric strength: flexion-extension, internal-external rotation and abduction-adduction of the shoulder; and flexion-extension of both elbow and wrist. Validity was examined by comparing the strength values from the low-cost digital dynamometer and those measured by an isokinetic dynamometer, assumed as the gold standard. The correlation between both devices was perfect (r > 0.913), while Bland-Altman plots showed absolute agreement between both devices, the maximum range of the values of bias was ?0.99–1.00 N in wrist extension. Inter-tester and intra-tester reliability were excellent for all movements (ICC ≥ 0.855). The low-cost digital dynamometer showed strong validity and excellent reliability in assessing maximal isometric strength during the main movements of the upper limb. Professionals may use it for an affordable isometric muscle strength assessment in field situations.     

Efficacy of Tumor Necrosis Factor and Interleukin-10 Analysis in the Follow-up of Nonalcoholic Fatty Liver Disease Progression

Tumor necrosis factor (TNF-α) is a cytokine involved in systemic inflammation during acute phase reactions. The current study was designed to investigate the levels of pro-inflammatory cytokine (TNF-α) along with the anti-inflammatory cytokine (IL-10) during progression of non-alcoholic fatty liver disease (NAFLD) from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis in diabetic patients, and correlate the levels of cytokines with the progression of NAFLD. Fifty-two diabetic patients compared to 18 healthy controls were participated in this study. Based on clinical diagnosis, patients were divided into three groups: simple steatosis, NASH and fibrosis. Serum liver function tests, fasting blood glucose, bilirubin, ALT, AST, TNF-α, IL-10 and lipid profile were measured. TNF-α levels were significantly higher in NAFLD patients compared to control subjects with a significant positive correlation with body mass index and fasting blood glucose (FBG) but with negative correlation with IL-10. Serum IL-10 levels were significantly lower in NAFLD patients compared with controls. A positive correlation between IL-10 and HDL-C with concomitant negative correlation between IL-10 and FBG and triacylglycerides was found. Cytokine analyses showed that there was a prominent imbalance between TNF-α and IL-10 in patients with NAFLD, and this imbalance increase by increasing the progression of NAFLD especially in obese diabetic patients. TNF-α and IL-10 could be used in diagnosis and follow-up of NAFLD stages in a way to avoid liver biopsies in greater proportion of patients.     

Outcomes of a scientific nonformal educational initiative for youth in Rio de Janeiro

The aim of this research is to understand how former students view their professional and academic paths after taking part in a specific scientific nonformal educational initiative during high school. This program is called Vocational Scientific Program (Provoc) and is carried out in the Oswald Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. This institution has for over 100 years played a pioneer role in public health research in the country. This institution has many graduate programs and a high school dedicated to training students in health issues. Provoc was originated in this school and has been part of it for the last 25 years. Since its beginning, this program has been characterized by a significant predominance of women which relates to the female predominance of professionals in this institution working in the traditional areas of Fiocruz, which are Biology, Medicine, Public Health, Humanities and Social Sciences. This study was qualitative in nature and involved observations and 34 individual interviews, which followed a semi structured questionnaire, designed for this research. The results indicate that the majority of participants see their program participation experiences as an asset in their academic and professional careers. Many describe feeling empowered by presenting their work in seminars and a few by writing a research article. Many former students also testified to the establishment of social long lasting relationships in the research work environment. And finally, the interviews reveal a few moments and the factors involved in the selection of a profession by youth.     

兴趣·调动·交际·指导——师专英语专业阅读课教学模式

阅读课是师专英语专业教学中的薄弱环节,而阅读课教学的效果直接影响到学生专业水平和技能的提高和发展。本文依据交际教学法等现代教学法理论和阅读心理学的原理,结合师专英语教学的实际,提出了“兴趣·调动·交际·指导”这样一个英语专业阅读课教学模式,并着重对这一模式的具体运用进行了较为详尽的阐释与评价