Drug-induced renal Fanconi syndrome: A case report

The renal Fanconi syndrome which results from renal tubular dysfunction can be either associated with various inbom errors of metabolism or acquired from various etiology. We report a case of gentamycin-induced Fanconi syndrome in a 4-month old infant who presented with aminoaciduria, glucosuria, phosphaturia and compensated metabolic acidosis.     

Optimal pruning for tree-structured vector quantization

Tree-structured vector quantization (VQ) is a technique designed to represent a codebook that simplifies encoding as well as vector quantizer design. Most design algorithms for tree-structured VQ used in the past are based on heuristics that successively partition the input space. Recently, Chou, Lookabaugh and Gray proposed a tree-pruning heuristic in which a given initial tree is pruned backwards according to certain optimization criterion. We define the notion of an optimal pruned tree subject to a cost constraint and study the computational complexity of finding such an optimal tree for various cost functions. Under the assumption that all trees are equally probable, we show that, on the average, the number of pruned trees in a given tree is exponential in the number of leaves. Furthermore, we prove that finding an optimal pruned tree subject to constraints such as entropy or the expected-depth is NP-hard. However, we show that when the constraint is the number of leaves, the problem can be solved in polynomial time. We develop an algorithm to find the optimal pruned tree in O(nk) time, where n is the size of the initial tree and kis the constraint size.     

Assessing basic research: Some partial indicators of scientific progress in radio astronomy

As the costs of certain types of scientific research have escalated and as growth rates in overall national science budgets have declined, so the need for an explicit science policy has grown more urgent. In order to establish priorities between research groups competing for scarce funds, one of the most important pieces of information needed by science policy-makers is an assessment of those groups' recent scientific performance. This paper suggests a method for evaluating that performance.After reviewing the literature on scientific assessment, we argue that, while there are no simple measures of the contributions to scientific knowledge made by scientists, there are a number of ‘partial indicators’ — that is, variables determined partly by the magnitude of the particular contributions, and partly by ‘other factors’. If the partial indicators are to yield reliable results, then the influence of these ‘other factors’ must be minimised. This is the aim of the method of ‘converging partial indicators’ proposed in this paper. We argue that the method overcomes many of the problems encountered in previous work on scientific assessment by incorporating the following elements: (1) the indicators are applied to research groups rather than individual scientists; (2) the indicators based on citations are seen as reflecting the impact, rather than the quality or importance, of the research work; (3) a range of indicators are employed, each of which focusses on different aspects of a group's performance; (4) the indicators are applied to matched groups, comparing ‘like’ with ‘like’ as far as possible; (5) because of the imperfect or partial nature of the indicators, only in those cases where they yield convergent results can it be assumed that the influence of the ‘other factors’ has been kept relatively small (i.e. the matching of the groups has been largely successful), and that the indicators therefore provide a reasonably reliable estimate of the contribution to scientific progress made by different research groups.In an empirical study of four radio astronomy observatories, the method of converging partial indicators is tested, and several of the indicators (publications per researcher, citations per paper, numbers of highly cited papers, and peer evaluation) are found to give fairly consistent results. The results are of relevance to two questions: (a) can basic research be assessed? (b) more specifically, can significant differences in the research performance of radio astronomy centres be identified? We would maintain that the evidence presented in this paper is sufficient to justify a positive answer to both these questions, and hence to show that the method of converging partial indicators can yield information useful to science policy-makers.     

The role of social embeddedness in professorial entrepreneurship: a comparison of electrical engineering and computer science at UC Berkeley and Stanford

Professorial entrepreneurship has recently attracted much attention. This paper draws upon historical research, a survey of faculty, and an Internet-based methodology for identifying professorial affiliations with entrepreneurial firms at two of the premier electrical engineering and computer science departments in the US, The University of California, Berkeley and Stanford. We employ the concept of “nested embeddedness” to explain why the faculty members in these two institutions have different levels of entrepreneurship and corporate involvement. EE&CS faculty at both universities were found to be socially embedded in departments and disciplines that supported and placed value on entrepreneurial activities. However, while being embedded in a university environment with a history of success and high level of support for entrepreneurship, EE&CS faculty at Stanford had a significantly greater level of corporate involvement, including the founding of start-ups. Although significantly less than Stanford, the level of corporate involvement among EE&CS faculty at Berkeley was also substantial. This suggests that being embedded in an academic department and disciplines with cultures that are supportive of entrepreneurial activity can help counteract the disincentives created by a university environment that is not strongly supportive of these activities.     

Building parallel corpora by automatic title alignment using length-based and text-based approaches

Cross-lingual semantic interoperability has drawn significant attention in recent digital library and World Wide Web research as the information in languages other than English has grown exponentially. Cross-lingual information retrieval (CLIR) across different European languages, such as English, Spanish, and French, has been widely explored; however, CLIR across European languages and Oriental languages is still in the initial stage. To cross language boundary, corpus-based approach is promising to overcome the limitation of the knowledge-based and controlled vocabulary approaches but collecting parallel corpora between European language and Oriental language is not an easy task. Length-based and text-based approaches are two major approaches to align parallel documents. In this paper, we investigate several techniques using these approaches and compare their performances in aligning English and Chinese titles of parallel documents available on the Web.     

Mindset change in a cross-cultural context

Imagine you are Thai and a member of a management team from a European company that acts in an Asian emerging market. Imagine you are a European expat with the assignment to double the turnover from that Asian company in a few years. Imagine you are a Change Maker and they ask you to facilitate the (multinational) management team of that Asian company to develop a market strategy and translate it into a business plan, and you have to deal with cultural differences. How do you manage a small-scale change process based on the principles of action learning in that specific multinational context? That's the essence of this account of practice.     

Marital conflict and conduct problems in Children of Twins

The Children-of-Twins design was used to test whether associations between marital conflict frequency and conduct problems can be replicated within the children of discordant twin pairs. A sample of 2,051 children (age 14-39 years) of 1,045 twins was used to estimate the genetic and environmental influences on marital conflict and determine whether genetic or environmental selection processes underlie the observed association between marital conflict and conduct problems. Results indicate that genetic and nonshared environmental factors influence the risk of marital conflict. Furthermore, genetic influences mediated the association between marital conflict frequency and conduct problems. These results highlight the need for quasiexperimental designs in investigations of intergenerational associations.     

Effects of national policies on teachers' sense of professionalism: findings from an empirical study in Portugal and in England

This paper reports on research aimed at investigating the ways in which teachers in Portugal and in England are experiencing recent changes in the policy environment which have affected their sense of professionalism and their professional identity. Data were collected through questionnaires and focus group interviews. Findings suggest the existence of some strengths in teachers' views on their professionalism, namely the importance of vocationalism, continuing learning and collaborative cultures, the relevance of project‐oriented work at school and an integrated perspective of the curriculum. However, a number of limitations also emerged, such as feelings of ambivalence and conflict, associated with increased bureaucracy, qualities of school leadership, cultures of loneliness and the lack of understanding and ownership of the process of change.

Cet article rend compte des données sur une étude réalisée au Portugal et en Angleterre sur la manière dont les enseignants des deux pays vivent les plus récents changements dans leur travail en résultat des politiques nationales. Plus concrètement, l'étude a analysé la manière dont les enseignants des deux pays caractérisent leur professionnalisme et leur identité professionnelle. Les données ont été recueillies à travers des questionnaires et des entretiens en groupe. Les résultats suggèrent quelques points forts, notamment l'importance du sentiment de vocation, de l'apprentissage continu, des cultures de collaboration et du travail de projet ainsi qu'une perspective intégrée du curriculum. Par contre, les points plus faibles ont été les sentiments d'ambivalence et de conflit, ainsi que la bureaucratie, la culture de solitude et l'absence de compréhension du processus de changement.

El artículo se basa en un estudio realizado por las Universidades del Minho (Portugal) y Nottingham (Inglaterra) sobre la forma como los profesores de los dos países han reaccionado a los recientes cambios en la política curricular, bien como sobre sus implicaciones en su profesionalismo y su identidad. Los datos fueron recogidos a través de cuestionario y entrevista de grupo. La lectura que surge de los datos indica un conjunto de puntos fuertes en la definición del profesionalismo de los profesores, especialmente la importancia atribuida al aprendizaje continuo y a las culturas de colaboración, así como la importancia del trabajo de proyecto y un entendimiento más amplio de los papeles de la escuela y de los profesores. Sin embargo, también surgieron algunas limitaciones, sobretodo en lo que respecta a sentimientos de alguna manera ambivalentes y conflictivos, determinados por el aumento de la burocracia, de la cultura individualista y la falta de comprensión y asimilación de los procesos de cambio.

Dieser Artikel berichtet über eine Studie, welche untersucht hat, inwiefern Lehrer aus Portugal und England die jüngsten Veränderungen im politischen Umfeld erleben, und inwiefern sich diese Veränderungen auf die berufliche Einstellung und Identität der Lehrer auswirken. Die Daten wurden durch Fragebögen und Fokusgruppeninterviews erhoben. Die Untersuchungsergebnisse zeigen, dass die Lehrer ihre Weiterbildung und Mitarbeitskultur, projektorientierte Schularbeit, eine integrierte Perspektive des Curriculums und ein breites Verständnis für die Schule und für die Lehrerarbeit als wichtig erachten. Es wurden jedoch auch einige Schwachpunkte identifiziert, wie beispielsweise mit erhöhtem Bürokratismus verbundene Ambivalenz‐ und Konfliktgefühle, Einsamkeitskultur, sowie Verständnislosigkeit gegenüber dem Veränderungsvorgang.     

Together I Can! Joint Attention Boosts 3- to 4-Year-Olds’ Performance in a Verbal False-Belief Test

Effects of joint attention were addressed on 3- to 4-year-olds’ performance in a verbal false-Belief Test (FBT), featuring the experimenter as co-watcher rather than narrator. In two experiments, children (N = 183) watched a filmed-FBT jointly with a test leader, disjointed from a test leader, or alone. Children attending jointly with a test leader were more likely to pass the FBT compared with normative data and to spontaneously recall information indicating false-belief understanding, suggesting that joint attention strengthens the plausibility of the FBT and renders plot-critical information more salient. In a third experiment (N = 59), results were replicated using a typical, image-based FBT. Overall findings highlight the profound impact of experimenter as social context in verbal FBTs, and link recall of specific story features to false-belief understanding.