肿节风注射液安全性实验评价

目的:对肿节风注射液进行异常毒性、溶血与凝聚试验、过敏反应安全性实验评价.方法:根据<中国药典>2010年版一部附录"中药注射剂安全性检查法应用指导原则"的要求及相关项目的技术规范进行试验.结果:按每只小鼠尾静脉注射0.5ml肿节风注射液,结果实验小鼠均无异常反应;溶血与凝聚试验供试品管中的溶液在3小时内不发生溶血和凝聚;按豚鼠腹腔注射0.5ml/只和静脉注射1.0ml/只作为本品的致敏剂量和激发剂量,结果试验豚鼠均未出现过敏反应.结论:本肿节风注射液进行的异常毒性、溶血与凝聚试验和致敏反应的安全性评价符合规定.     

Convergent genomic signatures of high-altitude adaptation among domestic mammals

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.     

中国科学院文献情报系统实施体制改革组建"中国科学院国家科学图书馆"

在中国科学院组织实施“三期知识创新工程”建设的总体框架下，中国科学院党组决定在文献情报系统实施体制机制改革，整合院级文献情报机构，组建中国科学院国家科学图书馆。     

云平台驱动的应急决策情报工程架构研究

[目的/意义]将情报工程思维融入云平台驱动的应急决策，旨在使应急决策更具效率性、科学性。[方法/过程]分析应急决策需求特性，在工程价值模型和情报系统基础上引入情报工程思维，即"事实数据"+"方法工具"+"专家智慧"3个要素，进而构建云平台驱动的应急决策情报工程架构。[结果/结论]云平台驱动的应急决策情报工程架构根据函数效应，从需求层（聚合需求，甄选信息）、工作层（挖掘情报，提升价值）、运行层（整合知识，集成智慧）以及服务层（快速响应，精准服务）4方面构建，使应急决策情报工程化及平行化，为应急决策在实际应用中提供一定思路。     

论图书馆自动备份系统的建构

自动备份系统的构建有利于数据备份管理，快速恢复系统和数据，保证业务高可用性运行。结合中国人民大学图书馆重要数据备份和恢复实际需求，探讨自动备份系统在图书馆中的实现。     

四川紫菊属二新种

Two new species of the genus Notoseris (Compositae) are  describep from Sichuan Province, China. They are Notoseris nanchuanensis Shih,  N. dolicho- phylla Shih.     

论远程考试

远程考试是远程教育发展的必然要求,是考试改革发展的必然要求。基于远程考试的法律基础、技术基础和社会基础,远程考试必须坚持科学性原则和以人为本的原则。     

试探解决中国乡村教育边缘化问题的对策

本文依据中国乡村教育边缘化的事实和特征，对现行乡村教育管理体制进行了结构功能分析，阐述了全球化与中国乡村教育边缘化的内在关联，提出了建立九年一贯制乡村学校、校长民主选举制、“喷灌式”乡村教育财政体制、乡村教师自治委员会基础上的校长负责制的乡村教育人、财、事的管理体制，以应对全球化的挑战。     

A long-term experiment to investigate the relationships between high school students’ perceptions of mobile learning and peer interaction and higher-order thinking tendencies

In this study, a one-year program was conducted to investigate the relationships between students’ perceptions of mobile learning and their tendencies of peer interaction and higher-order thinking in issue-based mobile learning activities. To achieve the research objective, a survey consisting of eight scales, namely, usability, continuity, adaptive content, collaboration, communication, problem-solving, critical thinking and creativity, was developed. A total of 658 students from 38 high schools in Taiwan filled in the questionnaire after experiencing issue-based mobile learning activities. From the exploratory and confirmatory factor analyses, it was found that the questionnaire had high reliability and validity. The structural equation model further revealed that the provision of adaptive content in the mobile learning had positive impacts on the students’ tendency to interact with peers (i.e., collaboration and communication), which further affected their tendency to engage in higher-order thinking (i.e., problem-solving, critical thinking, and creativity). The findings of this study provide a good reference for researchers and school teachers who intend to promote mobile learning in school settings.     

上海生命科学课程课堂教学目标的制定与实施

本文就上海生命科学课堂教学的教学过程提出建议及一些具体做法,以促进新课程理念更好地转化为课堂教学的实践。