Colorectal cancer detection in an asymptomatic population: fecal immunochemical test for hemoglobin vs. fecal M2-type pyruvate kinase

Introduction

Screening programs for colorectal cancer (CRC) are mainly based on a first-line fecal immunochemical test for hemoglobin (FIT). Fecal M2-type pyruvate kinase (M2-PK) has been evaluated in clinical settings showing promising results for early CRC detection. However, the impact of fecal M2-PK assessment on the performance of first-round CRC screening programs is not known. We investigated whether fecal M2-PK alone or in combination with FIT may improve CRC screening efficacy in the general population.

Materials and methods

A total of 1027 asymptomatic subjects (median age 66 [59-74] years; females 504 [49.1%]), identified through the general practitioners’ rosters, were invited for the collection of 2 fecal samples for FIT and M2-PK evaluation. Participants with at least positive one fecal test were referred for colonoscopy. Quality indicators for screening performance were calculated and analyzed using Fisher’s exact test.

Results

Overall, 572 subjects underwent both FIT and M2-PK assessment (participation rate 55.7%): 93 participants showed positive results for at least one test (positivity rate 16.3%). Only 10 patients were positive for both tests. Attendance rate to colonoscopy was 86.0% and a total of 65 adenomas and 7 cancers were detected. Combined use of FIT and fecal M2-PK permitted the identification of 18 more neoplasm (25%) without improving colonoscopy workload, as deduced by the comparable number needed to scope (P = 0.402).

Conclusion

The addition of M2-PK testing to FIT offers the potential to detect additional neoplasms that either do not bleed or only bleed intermittently without reducing participation rate and without increasing endoscopy workload.Key words: biomarker, colorectal cancer, occult blood, M2-type pyruvate kinase, screening     

A coach’s political use of video-based feedback: a case study in elite-level academy soccer

This paper examines the video-based pedagogical practices of Terry (pseudonym), a head coach of a professional junior academy squad. Data were collected through 6 in-depth, semi-structured interviews and 10 field observations of Terry’s video-based coaching in situ. Three embracing categories were generated from the data. These demonstrated that Terry’s video-based coaching was far from apolitical. Rather, Terry strategically used performance analysis technologies to help fulfil various objectives and outcomes that he understood to be expected of him within the club environment. Kelchtermans’ micropolitical perspective, Callero’s work addressing role and Groom et al.’s grounded theory were primarily utilised to make sense of Terry’s perceptions and actions. The findings point to the value of developing contextually grounded understandings of coaches’ uses of video-based performance analysis technology. Doing so could better prepare coaches for this aspect of their coaching practice.     

An Evolution of the Migration of Taiwanese Female Basketball Players: From the ‘American Dream’ to the ‘Chinese Dream’

Abstract

This paper explores the migration of female basketball players from Taiwan to China. Governance theory is adopted as the framework in this study to analyze the phenomenon of players’ migration and to understand how it was shaped over the years. The empirical work draws on a qualitative approach, which is based on a review of documentary materials and semi-structured interviews; coding and analysis were undertaken with a content analysis approach in order to investigate the decision-making processes and their consequences for the players’ migration. The feature of systematic governance for the development of women’s basketball has been revealed in this study. Stakeholders with personal interests caused the downturn of women’s basketball development in Taiwan, and it eventually led to the players’ migration abroad. Through the lens of governance theory, it has been revealed that a number of factors – namely, political, financial, personal, socio-economic, and cultural – all intertwine with one another dynamically to influence the female players’ decision to move abroad. This finding broadens the scope for the research of Taiwanese athletes’ migration to China, extending the focus from only business or industry to other aspects, thereby highlighting the fact that the subject is more complex than previously understood.     

Physical activity profiles and selected muscular fitness variables in English schoolchildren: A north–south divide?

The aim of the study was to compare and contrast habitual physical activity (PA) profiles and muscular fitness in schoolchildren from northern and southern regions of England. Data were collected from two secondary schools in the north east (NE) of England. The study procedures followed methods employed by the East of England Healthy Hearts Study in 10–16-year-old boys and girls based in the south east (SE) region of England and data were compared. Habitual physical activity (PAQ-A), vertical jump test, and hand-grip (HG) strength were assessed. We converted raw scores from all assessments to age- and sex-normalised z-scores. We recruited 597 children (58% boys) in the NE and compared findings to 597 age- and sex-matched boys and girls from the SE. Boys in the SE had significantly stronger HG scores, jumped higher, were more powerful (mean peak power: 2131?W vs. 1782?W; P?P?P?相似文献   

Special education and general education preservice teachers’ co-teaching experiences: a comparative synthesis of qualitative research

Co-teaching is commonly used to support students with disabilities in inclusive educational settings. However, there is often a gap between the potential effectiveness of co-teaching and actual classroom practice. This study examined preservice teachers’ co-teaching experiences to better understand this gap to identify potential practices for improving teacher training and service delivery. A review of 11 studies revealed that both special education and general education preservice teachers believed that co-teaching practices provided them opportunities to communicate and work collaboratively. Both groups agreed on the significant impact of personality in co-teaching as well as challenges in implementing co-teaching. Furthermore, special education preservice teachers noted that they lacked content knowledge, whereas general education preservice teachers thought they needed more training in the provision of accommodations and modifications. Study limitations, areas for future research, and implications for preservice teacher preparation are discussed.     

Statistical Power of the Multiple Domain Latent Growth Model for Detecting Group Differences

The latent growth model (LGM) in structural equation modeling (SEM) may be extended to allow for the modeling of associations among multiple latent growth trajectories, resulting in a multiple domain latent growth model (MDLGM). While the MDLGM is conceived as a more powerful multivariate analysis technique, the examination of its methodological performance is very limited. Hence, the present study compared the power of the MDLGM with that of a set of univariate LGMs for detecting group differences in growth rates over time using a Monte Carlo study with a two-group and two-domain design. The results indicated that there were different scenarios where the power rates for the MDLGM were greater than that of the set of LGMs (and vice versa) due to a joint function of the two domains’ intercorrelation size and the group difference effect size.     

Large amplitude free vibration of a flexible panel coupled with a leaking cavity

This paper addresses the effect of leakage on the natural frequencies of a large amplitude vibrating panel backed by a cavity, which has not been considered in many other related studies. The structural-acoustic governing equations are employed to study this nonlinear problem. An elliptical integral method, which was recently developed for the nonlinear panel cavity problem, is introduced here to solve for the structural-acoustics responses. The present results agree reasonably well with those obtained from the classical harmonic balance method. Modal convergences of the nonlinear solutions are performed to verify the proposed method. The effects of vibration amplitude and leakage size are studied and discussed. It is found that (1) the edge leakages in a panel cavity system significantly affect the natural frequency properties, and (2) the edge leakages induce a low frequency acoustic resonance.     

Examining Intermediate Omitted Levels in Hierarchical Designs via Latent Variable Modeling

This article outlines an interval estimation procedure that can be used in a 3-level setting to evaluate the proportion of outcome variance attributable to the second level of clustering. The method is useful for examining the necessity of including a possibly omitted intermediate level of nesting in analyses of data from a multilevel study, and represents an informative addendum to current statistical tests of second-level variance. The approach is developed within the framework of latent variable modeling and can be used as an aid in the process of choosing between 2-level and 3-level models in a hierarchical design. The discussed procedure is illustrated with an empirical example.