A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine

Understanding the ecology of the gastrointestinal tract and the impact of the contents on the host mucosa is emerging as an important area for defining both wellness and susceptibility to disease. Targeted delivery of drugs to treat specific small intestinal disorders such as small bowel bacterial overgrowth and targeting molecules to interrogate or to deliver vaccines to the remote regions of the small intestine has proven difficult. There is an unmet need for methodologies to release probes/drugs to remote regions of the gastrointestinal tract in furthering our understanding of gut health and pathogenesis. In order to address this concern, we need to know how the regional delivery of a surrogate labeled test compound is handled and in turn, if delivered locally as a liquid or powder, the dynamics of its subsequent handling and metabolism. In the studies we report on in this paper, we chose ¹³C sodium acetate (¹³C-acetate), which is a stable isotope probe that once absorbed in the small intestine can be readily measured non-invasively by collection and analysis of ¹³CO₂ in the breath. This would provide information of gastric emptying rates and an indication of the site of release and absorptive capacity. In a series of in vitro and in vivo pig experiments, we assessed the enteric-protective properties of a commercially available polymer EUDRAGIT®L100-55 on gelatin capsules and also on DRcaps®. Test results demonstrated that DRcaps®coated with EUDRAGIT®L100-55 possessed enhanced enteric-protective properties, particularly in vivo. These studies add to the body of knowledge regarding gastric emptying in pigs and also begin the process of gathering specifications for the design of a simple and cost-effective enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine.     

Cycling with noncircular chainring system changes the three-dimensional kinematics of the lower limbs

This study investigated the three-dimensional (3-D) pedaling kinematics using a noncircular chainring system and a conventional system. Five cyclists pedaled at their preferred cadence at a workload of 300 W using two crank systems. Flexion/extension of the hip, knee and ankle as well as shank rotation, foot adduction/abduction, and pedal angle were measured. Joint range of motion (ROM) and angular displacements were compared between the systems. Sagittal plane ROM was significantly greater (P < 0.05) at the hip (noncircular system = 39 ± 3°; conventional system = 34 ± 4°) the knee (noncircular system = 69 ± 4°; conventional system = 57 ± 10°), and ankle (noncircular system = 21 ± 2°; conventional system = 19 ± 4°) resulting in greater pedal ROM (noncircular system = 43 ± 3°; conventional system = 37 ± 5°) while using the noncircular system. Shank rotation ROM was significantly lower (P < 0.05) while using the noncircular chainring (noncircular system = 10 ± 1°; conventional system = 14 ± 1°). These results support a significant effect of the noncircular chainring system on pedaling kinematics during submaximal exercise.     

Computer Simulations Improve University Instructional Laboratories

Laboratory classes are commonplace and essential in biology departments but can sometimes be cumbersome, unreliable, and a drain on time and resources. As university intakes increase, pressure on budgets and staff time can often lead to reduction in practical class provision. Frequently, the ability to use laboratory equipment, mix solutions, and manipulate test animals are essential learning outcomes, and “wet” laboratory classes are thus appropriate. In others, however, interpretation and manipulation of the data are the primary learning outcomes, and here, computer-based simulations can provide a cheaper, easier, and less time- and labor-intensive alternative. We report the evaluation of two computer-based simulations of practical exercises: the first in chromosome analysis, the second in bioinformatics. Simulations can provide significant time savings to students (by a factor of four in our first case study) without affecting learning, as measured by performance in assessment. Moreover, under certain circumstances, performance can be improved by the use of simulations (by 7% in our second case study). We concluded that the introduction of these simulations can significantly enhance student learning where consideration of the learning outcomes indicates that it might be appropriate. In addition, they can offer significant benefits to teaching staff.     

Material characterization and preservation guidance for a collection of prosthetic limbs developed since 1960

National Museums Scotland has collections relating to many areas of science and technology, including medical science. This paper considers technical and conservation issues of an important collection of more than 150 prosthetic limbs. Much of the collection is of prosthetics developed for children born lacking or with malformed upper limbs caused by the prenatal morning sickness drug Thalidomide. However, many other examples are represented and the collection showcases a timeline of bioengineering development covering the past five decades. A wide range of plastics and metals were observed within the pieces examined, with many visibly degraded and degrading. The identification and characterization of these materials and their condition are fundamental to interpreting the development of the collection, for deciding on treatment, and for setting a strategy for future preservation. In addition to visual inspection, three analytical techniques were used to examine the various parts of the selected examples: Fourier transform infrared spectroscopy for polymer identification and condition; X-ray fluorescence spectroscopy to identify the metals and alloys present, and X-radiography to reveal the internal mechanisms of the limbs. Interpretation of the results was greatly enhanced by documentation and conversation with engineers and scientists involved in research and development of the limbs. The combination of different materials, some with conflicting environmental requirements, makes storage and display challenging as the goal is to prevent degradation of any part the object. Some objects were found to be actively degrading and for these separate storage solutions have been recommended to slow the emission of volatile degradation products that would cause further damage throughout the collection.     

Evaluation of the physical classroom by students and professors: a lens model approach

A method for linking classroom evaluations to specific physical properties and for comparing the evaluations of different groups is described and illustrated. Thirty-five college classrooms were photographed and shown to 20 professors and 51 undergraduate students, each of whom evaluated the friendliness of and their overall preference for all the classrooms. Seven physical properties of the classrooms were reliably assessed by independent observers. Using a modified Brunswik lens model, the relations between the physical properties and the evaluations by the two groups were established and compared. Between 40 and 57 per cent of the variance in the evaluations could be explained from only three classroom properties: view to outdoors, seating comfort and seating arrangement. Evaluations by the students and professors were surprisingly similar, an encouraging sign for classroom designers.     

Trust schools and the politics of persuasion and the mobilisation of interest

This paper sets out the theoretical and methodological approach of a study of the politics of persuasion and the mobilisation of interest in relation to the Trust schools initiative in England. Drawing on the discourse theoretical approach of Laclau and Mouffe the paper argues that the politics of consensus associated with New Labour reconfigures the field of politics, closing down legitimate democratic space. Building on this approach and that of policy sociology the paper outlines how the researchers seeks to address the following questions – if the space for legitimate democratic debate is so severely constrained then how does a social democratic government deal with the kind of opposition that Labour faced in relation to Trust schools? How do governments persuade dissident citizens to support unpopular policies? How are citizens mobilised to support such policies? This also raises questions about how, in such a restricted political space, do those questioning or resisting such policies, engage in the politics of persuasion and the mobilisation of interests? The reconfiguration of the field of politics and what this means for the constitution of legitimate democratic debate is the object of study of the research.     

Reducing prejudice: constructivist considerations for special education

ABSTRACT

How might teachers think about moving to challenge prejudice against persons with handicap? Drawing on Piaget's and Bateson's constructivist theories, prejudices are examined in terms of the processes by which they are formed within the individual, the role they play in identity, and the reasons they may be resistant to change. Consideration is then given to strategies which may be useful in inviting reconsideration of cognitive items of this type. Looking at the learner's experience these include certain types of questioning strategies and counterexamples. Looking at the teacher's experience a number of techniques are recommended including, neutrality, circular questioning, and parenthesising.     

Free agent learners: the new career model and its impact on human resource development

Changes in the job market are affecting how employees view their current positions and careers leading to more employees (so-called ‘free agents’) developing portfolio careers. To maintain their long-term employability, free agents need to continually enhance and expand their expertise, knowledge-base, reputation and networks, and it has been argued that this will influence how employees view and approach their workplace learning. This article reports the findings of qualitative research aimed at exploring the free agent concept, the implications for workplace learning and the implications for human resource development (HRD) functions in organizations. The research used a convenience sample of 11 organizations from three continents, with data collected from senior HRD executives through telephone and face-toface interviews and e-mails. The results highlighted how some employees are changing their attitudes towards workplace learning, particularly those considered ‘high potential’ or working in ‘high tech’ positions. The research also identified how organizations are increasingly viewing learning as a means of attracting and retaining high quality employees, with implications for HRD functions in terms of a greater emphasis on delivery methods for learning beyond traditional training and greater emphasis on career development activities.     

Childhood emotional maltreatment and later psychological distress among college students: The mediating role of maladaptive schemas

ObjectiveTheoretically, exposure to experiences of emotional abuse (EA) and emotional neglect (EN) in childhood may threaten the security of attachment relationships and result in maladaptive models of self and self-in-relation to others. The purpose of this study was to explore the extent to which EA and EN treatment by parents contributed uniquely to young adult maladaptive long-term outcome with respect to symptoms of anxiety, depression, and dissociation. The extent to which the relationships between EA and EN and later symptoms were mediated by specific internalized maladaptive interpersonal schemas was also explored.MethodsQuestionnaires completed by 301 college men and women (52% female) assessed perceptions of experiences of childhood abuse and neglect, exposure to parental alcoholism, current symptoms of psychological distress, and endorsement of maladaptive interpersonal schemas.ResultsHierarchical regression analyses revealed that perceptions of childhood EA and EN each continued to exert an influence on later symptoms after controlling for gender, income, parental alcoholism, and other child abuse experiences. Both EA and EN were associated with later symptoms of anxiety and depression and were mediated by schemas of vulnerability to harm, shame, and self-sacrifice. Only EN was related to later symptoms of dissociation; this relationship was mediated by the schemas of shame and vulnerability to harm.ConclusionThe findings are discussed from an attachment perspective, focusing on how early interactions with parents contribute to the development of internal working models of self and self-in-relation to others that influence later cognitive schemas and psychological adjustment.Practice implicationsAlthough emotional abuse and emotional neglect are the least studied of all forms of child maltreatment, they may be the most prevalent. The current findings suggest that how college students have evaluated and internalized these experiences may be even more important than the events themselves in determining the extent to which these experiences exert a long-term impact. For this reason, early intervention might be particularly important in helping to modify internal working models of the self as worthless, others as abusive, or the world as threatening and dangerous as a result of past abuse experiences. This study underscores the need for counselors to actively elicit and explore experiences of emotional abuse and neglect in clients, in addition to inquiring about other abuse experiences and types of family dysfunction.The results of this study also support existing data suggesting that internalized representational models of self and others are a key mechanism underlying the relationship between emotional maltreatment and later psychopathology. Young's schema questionnaire proved to be quite sensitive in detecting specific maladaptive schemas that mediated later difficulties with depression, anxiety, and dissociation. Targeting these negative schemas in therapy may help to ameliorate such symptoms. The therapeutic relationship provides a particularly effective context for developing more positive models of self and others, as well as providing a context to explore core relationship themes across different relationship contexts (e.g., intimate partner, parent, friend, and work relationships). In particular, if the assessment of the client reveals that dissociative symptoms are present, counselors can acknowledge the adaptive function that this strategy once served, while also addressing potential limitations to over-reliance on this coping strategy.