PERSONALITY PROFILES AND SELECTION FOR COURSES

16PF Personality profiles for 364 young civil engineers have been compared to the British Norms for the 16PF Questionnaire. Civil Engineers differ from the British Norms on five of the 20 factors derived from the Questionnaire. These factors indicate the questions on which to concentrate when selecting students for civil engineering courses.     

DIAGNOSTIC TESTS AND EXAMINATION RESULTS

The possibility of using diagnostic tests was explored and several tests were used with civil engineering students to see if they would be useful in selecting students for the civil engineering degree course. The performance of students on the tests used was compared with the examination results and it was found that the tests showed a little promise. It will be necessary to design a test specifically for civil engineering students. On the other hand perhaps our methods of teaching and examining subjects fundamental to civil engineering should be examined in depth. The results from the tests used indicated a culture gap between home and overseas students and the need for a database of student information.     

Psychometric Properties of the Full and Short Versions of the Quality of Life Instrument Package: Results from the Ontario province-wide study

Results that bear upon the psychometric properties of the Quality of Life Instrument Package are presented. The reliability and validity of quality of life data from a probability sample of 500 persons with developmental disabilities in Ontario were assessed. The data indicate that most of the instruments found in the package met acceptable psychometric standards. In some cases, specific domain scores need to be interpreted with caution. The Full Version of the instrument seems appropriate for ongoing practical program planning with clients. The Short Version seems especially appropriate for evaluation and monitoring purposes.     

Herceptin functionalized microfluidic polydimethylsiloxane devices for the capture of human epidermal growth factor receptor 2 positive circulating breast cancer cells

Building on recent breakthroughs in the field of microfluidic-based capture of rare cancer cells circulating in the blood, the present article reports on the use of Herceptin functionalized PDMS devices designed to efficiently capture from blood cancer cells, overexpressing the tyrosine kinase human epidermal growth factor receptor (HER2). The identification of patients overexpressing HER2 is critical as it typically associates with an aggressive disease course in breast cancer and poor prognosis. Importantly, HER2 positive patients have been found to significantly benefit from Herceptin (Trastuzumab), a humanized monoclonal antibody (MAb) against HER2. Disposable PDMS devices prepared using standard soft lithography were functionalized by the plasma polymerization of an epoxy-containing monomer. The epoxy-rich thin film (AGEpp) thus created could be conjugated with Herceptin either directly or through a polyethylene glycol interlayer. The properties and reactivity toward the monoclonal antibody conjugation of these coatings were determined using x-ray photoelectron spectroscopy; direct conjugation provided a good compromise in reactivity and resistance to biologically nonspecific fouling and was selected. Using the breast cancer cell line SK-BR-3 as a model for cells overexpressing HER2, the immunocapture efficacy of the Herceptin functionalized PDMS was demonstrated in model studies. Validation studies confirmed the ability of the device to efficiently capture (～80% capture yield) HER2 positive cells from full blood.