Increased plasma vaspin concentration in patients with sepsis: an exploratory examination

Introduction

Vaspin (visceral adipose tissue-derived serpin) was first described as an insulin-sensitizing adipose tissue hormone. Recently its anti-inflammatory function has been demonstrated. Since no appropriate data is available yet, we sought to investigate the plasma concentrations of vaspin in sepsis.

Materials and methods

57 patients in intensive care, fulfilling the ACCP/SCCM criteria for sepsis, were prospectively included in our exploratory study. The control group consisted of 48 critically ill patients, receiving intensive care after trauma or major surgery. Patients were matched by age, sex, weight and existence of diabetes before statistical analysis. Blood samples were collected on the day of diagnosis. Vaspin plasma concentrations were measured using a commercially available enzyme-linked immunosorbent assay.

Results

Vaspin concentrations were significantly higher in septic patients compared to the control group (0.3 (0.1-0.4) ng/mL vs. 0.1 (0.0-0.3) ng/mL, respectively; P < 0.001). Vaspin concentration showed weak positive correlation with concentration of C-reactive protein (CRP) (r = 0.31, P = 0.002) as well as with SAPS II (r = 0.34, P = 0.002) and maximum of SOFA (r = 0.39, P < 0.001) scoring systems, as tested for the overall study population.

Conclusion

In the sepsis group, vaspin plasma concentration was about three-fold as high as in the median surgical control group. We demonstrated a weak positive correlation between vaspin and CRP concentration, as well as with two scoring systems commonly used in intensive care settings. Although there seems to be some connection between vaspin and inflammation, its role in human sepsis needs to be evaluated further.Key words: adipocytokine, inflammation, vaspin, CRP, intensive care     

Wake up Information Literacy Instruction: Ideas for Student Engagement

In this article, three librarians from Santa Fe College, the community college winner of the 2015 ACRL Excellence in Academic Libraries Award, share their successful work in information literacy instruction. While the ACRL award is given for overall achievement, this article focuses upon their creative and varied approaches to instruction, incorporating a wide blend of strategies to reach students across the college. Beginning with targeted approaches to virtual instruction, including broad use of the flipped classroom model, and building in active learning techniques, the librarians at Santa Fe College have built an instruction program that could serve as a model to community college libraries across the country.     

Assessing the Worth of the College Degree on Self-perceived Police Performance

Many formal policies have suggested that officers need a college degree; however, policies forced little change in practices of American police organizations. Six hundred-fifty patrol officers employed in 12 medium-sized police departments in three Midwestern states were surveyed as to their current educational attainment and job performance. The purpose of this study was to determine the relationship between educational level and police performance.     

Caregiver speech predicts the emergence of children's emotion vocabulary

Learning about emotions is an important part of children's social and communicative development. How does children's emotion-related vocabulary emerge over development? How may emotion-related information in caregiver input support learning of emotion labels and other emotion-related words? This investigation examined language production and input among English-speaking toddlers (16–30 months) using two datasets: Wordbank (N = 5520; 36% female, 38% male, and 26% unknown gender; 1% Asian, 4% Black, 2% Hispanic, 40% White, 2% others, and 50% unknown ethnicity; collected in North America; dates of data collection unknown) and Child Language Data Exchange System (N = 587; 46% female, 44% male, 9% unknown gender, all unknown ethnicity; collected in North America and the UK; data collection dates, were available between 1962 and 2009). First, we show that toddlers develop the vocabulary to express increasingly wide ranges of emotional information during the first 2 years of life. Computational measures of word valence showed that emotion labels are embedded in a rich network of words with related valence. Second, we show that caregivers leverage these semantic connections in ways that may scaffold children's learning of emotion and mental state labels. This research suggests that young children use the dynamics of language input to construct emotion word meanings, and provides new techniques for defining the quality of infant-directed speech.