A Study on the Level of T<Subscript>3</Subscript>, T<Subscript>4</Subscript>, TSH and the Association of A/G Polymorphism with CTLA-4 Gene in Graves’ Hyperthyroidism among South Indian Population

Graves’ disease (GD) is an organ-specific heterogenous autoimmune disorder associated with T-lymphocyte abnormality affecting the thyroid, eyes and skin. GD is a multifactorial disease that develops as a result of complex interaction between genetic susceptibility genes and environmental factors. It has been suggested that the Cytotoxic T lymphocytes associated molecule-4 (CTLA-4) is a genetic susceptibility candidate for GD. The present study was focused on A/G polymorphism at position 49 in exon-1 of the CTLA-4 gene in 80 GD patients (GP) and 80 sex and age matched healthy individuals among South Indian (Madurai) population. Serum concentrations of thyroid hormone (T₄, T₃ and TSH) were determined by using automated analyzer. The genomic DNA was isolated from the patient and control groups and genotyping was performed using the polymerase chain reaction followed by restriction enzyme analysis using Bbv1. Significant difference (P < 0.001) was observed in the level of T₃, T₄ and TSH in GD patients and healthy individuals. The results revealed the CTLA-4 gene G/G genotype to be 32 (40%) in patients and 26 (32.50%) in healthy individuals, A/G genotype to be 37 (46.25%) in patients and 25 (31.25%) in healthy individuals and A/A genotype to be 11 (13.75%) in patients and 29 (36.25%) in healthy individuals. The calculated odds ratio (OR) in individuals with mutant genotype (GG/AG) reveal 3.6 fold risk for GD (95% confidence interval = 1.6–7.8). The mutant “G” allele frequency was observed to be 0.63 in GD patients and 0.48 in healthy individuals. Thus the present study demonstrates an association between the CTLA-4 gene polymorphism and Graves’ disease.     

Organ Specific Tumor Markers: What’s New?

Tumor markers are molecules produced in the body in response to cancer. An ideal tumor marker should have high sensitivity and specificity, should be cheap, and should be easily detected in body fluids. Identification of novel markers is important and it is expected that with the advent of newer technologies, more reliable markers will be discovered. This review discusses the currently available tumor markers for different malignancies.     

A dynamic analysis of social capital-building of international and UK students

Although many international students experience transitional issues, most research assumes these issues will disappear over time. Using principles of social capital theory, this study addressed whether after three years of study students were able to build multi-national and host social capital links. In this quantitative study of 81 students from 28 nationalities, the results indicate that Confucian Asian students lived in separate social worlds, while English and other international students developed substantial multi-national networks over time. Learning networks after 14?weeks were predicted by group allocation and initial friendships, indicating a positive effect of mixing multi-national groups.     

Evaluating the Operational Feasibility of Using Subsets of Items to Recommend Minimal Competency Cut Scores

Establishing cut scores using the Angoff method requires panelists to evaluate every item on a test and make a probability judgment. This can be time-consuming when there are large numbers of items on the test. Previous research using resampling studies suggest that it is possible to recommend stable Angoff-based cut score estimates using a content-stratified subset of ?45 items. Recommendations from earlier work were directly applied in this study in two operational standard-setting meetings. Angoff cut scores from two panels of raters were collected at each study, wherein one panel established the cut score based on the entire test, and another comparable panel first used a proportionally stratified subset of 45 items, and subsequently used the entire test in recommending the cut scores. The cut scores recommended for the subset of items were compared to the cut scores recommended based on the entire test for the same panel, and a comparable independent panel. Results from both studies suggest that cut scores recommended using a subset of items are comparable (i.e., within one standard error) to the cut score estimates from the full test.     

Nature watch

Fascinating and grand, with curious beaks and breeding habits, hornbills are a naturalist’s delight. In forest types ranging from open savannah to rainforest across Africa and Asia, they occupy the pride of place among birds and play a pivotal role as mutualistic frugivores and seed dispersers of various trees. Due to the impact of humans on hornbills and their habitats, most species are now endangered. Fortunately, there has been some success in recent conservation efforts to save these magnificent forest flagships.     

DSJIE: Reflections on the past and a look to the future

As the Decision Sciences Journal of Innovative Education embarks on its third decade, a former editor reflects on the first two decades and offers thoughts on the future of the journal and decision sciences education.     

Evaluating the Consistency of Angoff-Based Cut Scores Using Subsets of Items Within a Generalizability Theory Framework

The Angoff method requires experts to view every item on the test and make a probability judgment. This can be time consuming when there are large numbers of items on the test. In this study, a G-theory framework was used to determine if a subset of items can be used to make generalizable cut-score recommendations. Angoff ratings (i.e., probability judgments) from previously conducted standard setting studies were used first in a re-sampling study, followed by D-studies. For the re-sampling study, proportionally stratified subsets of items were extracted under various sampling and test-length conditions. The mean cut score, variance components, expected standard error (SE) around the mean cut score, and root-mean-squared deviation (RMSD) across 1,000 replications were estimated at each study condition. The SE and the RMSD decreased as the number of items increased, but this reduction tapered off after approximately 45 items. Subsequently, D-studies were performed on the same datasets. The expected SE was computed at various test lengths. Results from both studies are consistent with previous research indicating that between 40–50 items are sufficient to make generalizable cut score recommendations.     

Growth of journals,articles and authors in malaria research

In the present study we have tried to trace the growth of malaria research at Global Level and the distribution of articles in various journals for the period 1955–2005. The data have been extracted from a database, which has been developed in-house from MEDLINE, SCI, TDB, Ovid Heath Information and Indian Science Abstracts. Study indicates that the exponential model fits the data on journals, articles and authors. The R² value for the trend for journals, articles, and authors are 0.9502, 0.9475, and 0.9651, respectively. The growth rates for journals, articles and authors are 5.31%, 7.38%, and 10.06%, respectively. The linear multiple regression equation that Articles = ?39.2771 + 3.61719*journals + 0.085882*Authors (R² = 99.16%) is most meaningful and it may be used to estimate the articles for given numbers of journals and authors.     

Interpretation of Score Reports by Diverse Subgroups of Parents

The degree to which diverse score users can understand and consume information presented in score reports dictates whether they are able to draw reasonable conclusions. The goal of this study was to understand how parents (a particularly understudied and heterogeneous stakeholder population) make interpretations from a hypothetical interactive score report. We used cognitive laboratories to evaluate how 35 parents from diverse educational and language proficiency backgrounds make sense of the information presented in hypothetical K-12 score reports. Results from this study demonstrate the diversity in the levels of comprehension across the assessed subgroups of parents, and highlight the need for and importance of additional support materials that can help parents understand and make sense of the information presented in score reports. Nevertheless, due to the hypothetical nature of the score report mockup evaluated and the small sample sizes, these results should be substantiated with additional research.