The relationship between parental bonding and peer victimization: examining child stress and hopelessness as mediators

The purpose of the current study was to investigate a two-stage model in which parent-related stress and hopelessness each served as mediators of the relationship between perceived parental bonding and South Korean adolescent peer victimization. This study also examined whether the mediating relationships differed by the gender of parents and adolescents. A casual chain with three links and four sets of variables were analyzed using structural equation modeling. Data were collected from 800 adolescents attending 10 middle schools in the Busan region of South Korea. Results indicated that both maternal and paternal parental bonding were negatively associated with stress, stress was positively associated with hopelessness, and hopelessness was positively associated with South Korean adolescent peer victimization. Most importantly, the significant negative associations between both maternal and paternal parental bonding and peer victimization were mediated by both stress and hopelessness. Furthermore, gender differences in these relationships existed for both parents and adolescents. Limitations and implications to practice were discussed.     

Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein

Multidrug resistance (MDR) is the major impediment to cancer chemotherapy. The expression of lung resistance-related protein (LRP), a non-ATP-binding cassette (ABC) transporter, is high in tumor cells, resulting in their resistance to a variety of cytotoxic drugs. However, the function of LRP in tumor drug resistance is not yet explicit. Our previous studies had shown that Kinesin KIF4A was overexpressed in cisplatin (DDP)-resistant human lung adenocarcinoma cells (A549/DDP cells) compared with A549 cells. The expression of KIF4A in A549 or A549/DDP cells significantly affects cisplatin resistance but the detailed mechanisms remain unclear. Here, we performed co-immunoprecipitation experiments to show that the tail domain of KIF4A interacted with the N-terminal of LRP. Immunofluorescence images showed that both the ability of binding to LRP and the motility of KIF4A were essential for the dispersed cytoplasm distribution of LRP. Altogether, our results shed light on a potential mechanism in that motor protein KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane. Thus KIF4A might be a cisplatin resistance-associated protein and serves as a potential target for chemotherapeutic drug resistance in lung cancer.     

谈谈投标的施工组织设计

通过对投标施工组织设计作用及特点的分析，阐述了投标施工组织设计在招投标过程中的重要性并指出了投标施工组织设计编制过程中一些经常易被忽视的重要问题。目的在于引导读者如何编制好投标施工组织设计文件。     

DNA甲基化异常与肿瘤发生的研究

DNA甲基化是真核生物DNA的正常内源性修饰方式 ,它由DNA甲基化转移酶催化发生。但DNA甲基化异常在肿瘤发生中却起着极为重要的作用 ,它主要表现为抑癌基因高甲基化所致的基因失活和原癌基因低甲基化所致的基因激活 ,引起与细胞增殖、分化相关基因表达异常 ,造成细胞恶变形成肿瘤。文章总结了DNA甲基化异常对肿瘤相关基因表达的影响 ,在肿瘤发生中的可能机制及针对高甲基化的治疗方案     

新媒体环境下的信息治理问题研究

[目的/意义]近年来,在新媒体逐渐发展成熟的情况下,微博、微信、QQ、问答社区等泛网络产品成为网络用户进行信息交流的主要方式,这些新媒体平台在方便用户的同时,也存在明显的信息生态问题,本文尝试针对这些问题提出治理对策。[方法/过程]本文分析了新媒体环境的特征,提出了新媒体环境下的信息传播和信息治理模型,针对信息治理问题展开一系列探讨。[结果/结论]本文提出的新媒体环境下的信息传播模型和信息治理建议可为解决新媒体环境下的信息生态问题提供一些思路。     

建设学习型社会和组织是创新战略的重要组成部分

奥地利裔美籍经济学家熊比特(JosephSchumpeter,1883—1950)的创新理论属于经济学范畴,它作为与德国思想家和经济学家马克思(Karl Marx,1818—1883)的理论和英国经济学家凯恩思(John Maynard Keynes,1883—1946)的理论相对立的理论,以新生产函数的产生解释资本主义经济的增长。但它的发展逐渐超越了其原始意义,由于发展到国家创新系统研究而涉及到人类社会的全面发展问题。他赋予创新以“创造性的毁灭”的思想,按照中国文化传统可以理解为革故鼎新、除旧布新和破旧立新,可以使之拓展到整个人类社会生活领域。在这个意义上我们可以讨论人…     

中国水生植物新记录属——钻叶荠属(十字花科)

 报道中国十字花科一新记录属¾钻叶荠属Subularia L. 及一新记录种¾钻叶荠S. aquatica L.。     

基于结构特征的商业模式创新:路径类型、产业效应与策略体系

通过对商业模式的结构化研究，本文分析了商业模式创新的主要促进因素及其影响机制，同时还探讨了商业模式创新对产业结构等宏观环境因素的影响途径、方式。基于其结构特征，本文划分了商业模式创新的类型，并据此提出了若干基础性假设，为进一步理论研究、政策制定和创新者实践提供必要的依据。     

微信公众号导航网站发展现状与趋势

[目的/意义]面对大量涌现的微信公众号,如何帮助用户快速、准确地获取所需信息是目前亟待解决的问题。公众号导航网站的出现部分解决了这个问题,但仍存在很多不足。本文欲针对此问题寻求优化措施及方法。[方法/过程]对较有代表性的微信公众号导航网站进行研究,将其与传统的网址导航网站进行异同分析,还针对微信公众号的评价问题及导航网站的发展思路提出了若干建议,最后还探讨了导航网站的发展趋势。[结果/结论]本文提出的改进设想可为微信公众号导航网站的发展提供参考。     

从南部档案浅析清代地方司法中的保释

清代地方司法中的保释是指案件在审理结束后,部分诉讼参与者被官府管禁,由保人向官府提交保释请求,待承审官批准后解除其管禁状态的司法活动。它是清代一项基本的司法程序,也是官府为了震慑、管理讼民,维持基层司法稳定而采取的行之有效的司法实践之一。保释程序的相关环节有其特殊性:一方面清代法规对保释有诸多制度性规定;一方面承审官对保释的审批有时并不以也难以将"法律"作为唯一依据。保人利用保释策略企图达到保释目的,而承审官个人的治讼理念与怜悯之心等因素同样会影响到其审判结果,反映出官民在司法领域但又基于法律之外的一种博弈互动。本文以南部档案中从道光七年(1827)至宣统三年(1911)的193件保状档案为主要资料,结合清代律例、官书,拟对清代司法中的保释及其程序运作中的官民互动作一考察。