木立芦荟中芦荟甙的TLC分析

采用超声提取方法，对木立芦荟中芦荟甙进行了提取，并用薄层色谱法(TLC)测定了木立芦荟中芦荟甙的含量．回收率为98．71％，变异系数为1．9％。     

西方视角下的东方神话——解读赛珍珠的《大地》

赛珍珠的《大地》是一个独特的文化现象。它是西方视角与中国精神的奇妙结合，作者采用了适度“神话”的方式来对待中国历史。同时，在小说艺术手法上，赛珍珠采用“奇迹”的写作方式和与生活真实适当疏离的方法营造一种传奇色彩，曲折地反映了作者的审美理想。这种写作态度集中体现在对主人公王龙三次婚姻生活的描写上。     

美国社区学院对我国成人教育的启示

社区学院是美国的独创之物,在经历了一个世纪的蓬勃发展之后,如今已遍布美国各地,并已显示出勃勃生机。作为美国高等教育“金字塔”的基础,社区学院以其开放性、多科性、综合性、服务性以及广泛的适应性在教育等方面发挥了重要的职能,被认为是美国教育的最大成果之一,其成长发展的历史经验对发展我国的成人教育具有一定的启示和借鉴意义。     

高等学校院级教学质量保障体系构建的探索--以东北农业大学农学院为例

以东北农业大学农学院为例,对高等学校院级教学质量保障体系进行初步探索,分析影响教学质量保障体系的要素和关键环节,针对教学质量保障体系制定纲要、基本框架、运行流程和具体实施条件,从多个角度不断完善院级保障体系的内容和运行机制,形成院级教学质量保障体系的组织管理、监控和评价系统,并对构建后的体系进行实施和完善,旨在不断提高本科教学质量。     

The relationship between parental bonding and peer victimization: examining child stress and hopelessness as mediators

The purpose of the current study was to investigate a two-stage model in which parent-related stress and hopelessness each served as mediators of the relationship between perceived parental bonding and South Korean adolescent peer victimization. This study also examined whether the mediating relationships differed by the gender of parents and adolescents. A casual chain with three links and four sets of variables were analyzed using structural equation modeling. Data were collected from 800 adolescents attending 10 middle schools in the Busan region of South Korea. Results indicated that both maternal and paternal parental bonding were negatively associated with stress, stress was positively associated with hopelessness, and hopelessness was positively associated with South Korean adolescent peer victimization. Most importantly, the significant negative associations between both maternal and paternal parental bonding and peer victimization were mediated by both stress and hopelessness. Furthermore, gender differences in these relationships existed for both parents and adolescents. Limitations and implications to practice were discussed.     

Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein

Multidrug resistance (MDR) is the major impediment to cancer chemotherapy. The expression of lung resistance-related protein (LRP), a non-ATP-binding cassette (ABC) transporter, is high in tumor cells, resulting in their resistance to a variety of cytotoxic drugs. However, the function of LRP in tumor drug resistance is not yet explicit. Our previous studies had shown that Kinesin KIF4A was overexpressed in cisplatin (DDP)-resistant human lung adenocarcinoma cells (A549/DDP cells) compared with A549 cells. The expression of KIF4A in A549 or A549/DDP cells significantly affects cisplatin resistance but the detailed mechanisms remain unclear. Here, we performed co-immunoprecipitation experiments to show that the tail domain of KIF4A interacted with the N-terminal of LRP. Immunofluorescence images showed that both the ability of binding to LRP and the motility of KIF4A were essential for the dispersed cytoplasm distribution of LRP. Altogether, our results shed light on a potential mechanism in that motor protein KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane. Thus KIF4A might be a cisplatin resistance-associated protein and serves as a potential target for chemotherapeutic drug resistance in lung cancer.     

谈谈投标的施工组织设计

通过对投标施工组织设计作用及特点的分析，阐述了投标施工组织设计在招投标过程中的重要性并指出了投标施工组织设计编制过程中一些经常易被忽视的重要问题。目的在于引导读者如何编制好投标施工组织设计文件。     

DNA甲基化异常与肿瘤发生的研究

DNA甲基化是真核生物DNA的正常内源性修饰方式 ,它由DNA甲基化转移酶催化发生。但DNA甲基化异常在肿瘤发生中却起着极为重要的作用 ,它主要表现为抑癌基因高甲基化所致的基因失活和原癌基因低甲基化所致的基因激活 ,引起与细胞增殖、分化相关基因表达异常 ,造成细胞恶变形成肿瘤。文章总结了DNA甲基化异常对肿瘤相关基因表达的影响 ,在肿瘤发生中的可能机制及针对高甲基化的治疗方案     

新媒体环境下的信息治理问题研究

[目的/意义]近年来,在新媒体逐渐发展成熟的情况下,微博、微信、QQ、问答社区等泛网络产品成为网络用户进行信息交流的主要方式,这些新媒体平台在方便用户的同时,也存在明显的信息生态问题,本文尝试针对这些问题提出治理对策。[方法/过程]本文分析了新媒体环境的特征,提出了新媒体环境下的信息传播和信息治理模型,针对信息治理问题展开一系列探讨。[结果/结论]本文提出的新媒体环境下的信息传播模型和信息治理建议可为解决新媒体环境下的信息生态问题提供一些思路。     

建设学习型社会和组织是创新战略的重要组成部分

奥地利裔美籍经济学家熊比特(JosephSchumpeter,1883—1950)的创新理论属于经济学范畴,它作为与德国思想家和经济学家马克思(Karl Marx,1818—1883)的理论和英国经济学家凯恩思(John Maynard Keynes,1883—1946)的理论相对立的理论,以新生产函数的产生解释资本主义经济的增长。但它的发展逐渐超越了其原始意义,由于发展到国家创新系统研究而涉及到人类社会的全面发展问题。他赋予创新以“创造性的毁灭”的思想,按照中国文化传统可以理解为革故鼎新、除旧布新和破旧立新,可以使之拓展到整个人类社会生活领域。在这个意义上我们可以讨论人…