《功能性食品加工技术》课程改革的实践

通过对《功能性食品加工技术》课程教学内容、教学方法、考核方式等的全面改革实践,提出追踪行业技术前沿调整教学内容,模拟企业管理形式进行教学组织,贯穿教学全过程进行考核的教学模式是调动学生学习主动性,提高综合职业素质的有效途径。     

The relationship between parental bonding and peer victimization: examining child stress and hopelessness as mediators

The purpose of the current study was to investigate a two-stage model in which parent-related stress and hopelessness each served as mediators of the relationship between perceived parental bonding and South Korean adolescent peer victimization. This study also examined whether the mediating relationships differed by the gender of parents and adolescents. A casual chain with three links and four sets of variables were analyzed using structural equation modeling. Data were collected from 800 adolescents attending 10 middle schools in the Busan region of South Korea. Results indicated that both maternal and paternal parental bonding were negatively associated with stress, stress was positively associated with hopelessness, and hopelessness was positively associated with South Korean adolescent peer victimization. Most importantly, the significant negative associations between both maternal and paternal parental bonding and peer victimization were mediated by both stress and hopelessness. Furthermore, gender differences in these relationships existed for both parents and adolescents. Limitations and implications to practice were discussed.     

Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein

Multidrug resistance (MDR) is the major impediment to cancer chemotherapy. The expression of lung resistance-related protein (LRP), a non-ATP-binding cassette (ABC) transporter, is high in tumor cells, resulting in their resistance to a variety of cytotoxic drugs. However, the function of LRP in tumor drug resistance is not yet explicit. Our previous studies had shown that Kinesin KIF4A was overexpressed in cisplatin (DDP)-resistant human lung adenocarcinoma cells (A549/DDP cells) compared with A549 cells. The expression of KIF4A in A549 or A549/DDP cells significantly affects cisplatin resistance but the detailed mechanisms remain unclear. Here, we performed co-immunoprecipitation experiments to show that the tail domain of KIF4A interacted with the N-terminal of LRP. Immunofluorescence images showed that both the ability of binding to LRP and the motility of KIF4A were essential for the dispersed cytoplasm distribution of LRP. Altogether, our results shed light on a potential mechanism in that motor protein KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane. Thus KIF4A might be a cisplatin resistance-associated protein and serves as a potential target for chemotherapeutic drug resistance in lung cancer.     

浅析惠州地区墙体材料的选择

本文通过对惠州地区建筑工程所用墙体材料的调查与分析, 并通过对烧结普通砖与新型墙体材料各项物理力学性能及经济指标的比较, 着重阐述了在实际工程当中惠州地区应广泛采用新型墙体材料的重要性, 以及大力推广墙体改革的必要性.     

地脉、文脉及旅游开发主题

旅游项目成败的关键在于正确确定旅游开发主题，而主题的确定又取决于对当地地脉、脉的准确把握和对客源市场的深入分析及定位。章主要探讨了旅游开发主题与当地的地脉和脉存在着的三种关系，并在此基础上提出正确确定旅游开发主题的构思原则及步骤。     

谈谈投标的施工组织设计

通过对投标施工组织设计作用及特点的分析，阐述了投标施工组织设计在招投标过程中的重要性并指出了投标施工组织设计编制过程中一些经常易被忽视的重要问题。目的在于引导读者如何编制好投标施工组织设计文件。     

DNA甲基化异常与肿瘤发生的研究

DNA甲基化是真核生物DNA的正常内源性修饰方式 ,它由DNA甲基化转移酶催化发生。但DNA甲基化异常在肿瘤发生中却起着极为重要的作用 ,它主要表现为抑癌基因高甲基化所致的基因失活和原癌基因低甲基化所致的基因激活 ,引起与细胞增殖、分化相关基因表达异常 ,造成细胞恶变形成肿瘤。文章总结了DNA甲基化异常对肿瘤相关基因表达的影响 ,在肿瘤发生中的可能机制及针对高甲基化的治疗方案     

建设学习型社会和组织是创新战略的重要组成部分

奥地利裔美籍经济学家熊比特(JosephSchumpeter,1883—1950)的创新理论属于经济学范畴,它作为与德国思想家和经济学家马克思(Karl Marx,1818—1883)的理论和英国经济学家凯恩思(John Maynard Keynes,1883—1946)的理论相对立的理论,以新生产函数的产生解释资本主义经济的增长。但它的发展逐渐超越了其原始意义,由于发展到国家创新系统研究而涉及到人类社会的全面发展问题。他赋予创新以“创造性的毁灭”的思想,按照中国文化传统可以理解为革故鼎新、除旧布新和破旧立新,可以使之拓展到整个人类社会生活领域。在这个意义上我们可以讨论人…     

中国水生植物新记录属——钻叶荠属(十字花科)

 报道中国十字花科一新记录属¾钻叶荠属Subularia L. 及一新记录种¾钻叶荠S. aquatica L.。     

基于结构特征的商业模式创新:路径类型、产业效应与策略体系

通过对商业模式的结构化研究，本文分析了商业模式创新的主要促进因素及其影响机制，同时还探讨了商业模式创新对产业结构等宏观环境因素的影响途径、方式。基于其结构特征，本文划分了商业模式创新的类型，并据此提出了若干基础性假设，为进一步理论研究、政策制定和创新者实践提供必要的依据。