Filtration of micro-particles within multi-fiber arrays by adhesive DEM-CFD simulation

A 3D multi-time scale discrete element method-computational fluid dynamic (DEM-CFD) coupling approach was applied to investigate the filtration of micron-sized particles by different types of fiber arrays. Both the pressure drop and the filtration efficiency were examined to indicate the filtration performance of the fiber arrays. Fibers that were uniformly arrayed in a parallel or staggered manner were compared. Results showed that the staggered array showed a better performance than the parallel array in terms of both pressure drop and filtration efficiency. Further, we compared the performance of different staggered arrays, i.e. a regular case, one densified in the front layers and another densified in the back layers. The front densified array was found to enter the clogging and cake filtration stage in the shortest time, leading to the highest filtration efficiency, but the highest pressure drop. The back densified array still achieved a much higher filtration efficiency, despite a much lower pressure drop comparable to that of the regular array. The results suggest that the two kinds of densified arrays may be suited for different purposes, e.g. baghouse filters or breathing masks.     

A novel multi-objective optimization method for the pressurized reservoir in hydraulic robotics

The pressurized reservoir is a closed hydraulic tank which plays a significant role in enhancing the capabilities of hydraulic driven robotics. The spring pressurized reservoir adopted in this paper requires comprehensive performance, such as weight, size, fluid volume, and pressure, which is hard to balance. A novel interactive multi-objective optimization approach, the feasible space tightening method, is proposed, which is efficient in solving complicated engineering design problems where multiple objectives are determined by multiple design variables. This method provides sufficient information to the designer by visualizing the performance trends within the feasible space as well as its relationship with the design variables. A step towards the final solution could be made by raising the threshold on performance indicators interactively, so that the feasible space is reduced and the remaining solutions are more preferred by the designer. With the help of this new method, the preferred solution of a spring pressurized reservoir is found. Practicability and efficiency are demonstrated in the optimal design process, where the solution is determined within four rounds of interaction between the designer and the optimization program. Tests on the designed prototype show good results.     

Integrating Tinbergen's inquiries: Mimicry and play in humans and other social mammals

Visual signals convey emotions and intentions between individuals. Darwin underlined that human facial expressions represent a shared heritage between our species and many other social mammals. Social play is a fertile field to examine the role and the potential communicative function of facial expressions. The relaxed open-mouth (or play face) is a context-specific playful expression, which is widespread in human and non-human mammals. Here, we focus on playful communication by applying Tinbergen’s four areas of inquiry: proximate causation, ontogeny, function, and evolution. First of all we explore mimicry by focusing on its neural substrates and factors of modulation within playful and non-playful context (proximate causation). Play face is one of the earliest facial expressions to appear and be mimicked in neonates. The motor resonance between infants and their caregivers is essential later in life when individuals begin to engage in increasingly complex social interactions, including play (ontogeny). The success of a playful session can be evaluated by its duration in time. Mirroring facial expressions prolongs the session by favoring individuals to fine-tune their own motor sequences accordingly (function). Finally, through a comparative approach we also demonstrate that the elements constituting play communication and mimicry are sensitive to the quality of interindividual relationships of a species, thus reflecting the nature of its social network and style (evolution). In conclusion, our goal is to integrate Tinbergen’s four areas of ethological inquiry to provide a broader framework regarding the importance of communication and mimicry in the play domain of humans and other social mammals.     

Contradictions,dialectical oppositions and shifts in teaching mathematics

The study reported in this paper concerns the tensions and conflicts that teachers experience while they enact a new set of reform-oriented curricular materials into their classrooms. Our focus is οn the interactions developed in two groups of teachers in two schools for a period of a school year. We use Activity Theory to study emerging contradictions and we elaborate on the construct of dialectical opposition to understand the nature of these contradictions and their potential for teacher learning. We provide evidence that discussions about contradictions and their dialectical character in the two groups support teachers to engage differently in mathematics teaching and learning and carry potentials for shifts in the practices that evolve in their classrooms. Our study addresses empirically in the context of mathematics teaching the philosophical claim about the role of contradictions as a driving force for any dynamic system.     

Returns on vocational education over the life cycle: Between immediate labour market preparation and lifelong employability

An important issue in the design of secondary-level education is the balance between conveying general and occupation-specific (vocational) skills. On the one hand, vocationally oriented programmes, providing occupation-specific skills with immediate labour market relevance, have repeatedly been shown to secure safe pathways into employment. On the other hand, these programmes tend to put less emphasis on developing general knowledge, skills and competencies, including numeracy and literacy, which are foundational to lifelong learning. Hence, when the needs of the labour market change, employees who opted for a vocational track when they were at secondary school risk being less flexible in adapting to such changes later in their career. The authors of this article examine whether this results in a trade-off between short-term gains and long-term losses by considering differences in the labour market careers of vocationally and generally educated respondents in the 2012 Programme for the International Assessment of Adult Competencies (PIAAC). Their results suggest that early labour market benefits of vocational specialisation decrease over time; the authors relate this to its lower ability to equip secondary school students – future employees – with skills for lifelong learning.     

A Novel Whiteheadean Science Program for 14-16 Year Olds in England and Wales

A novel “Whiteheadean” science program was initiated in England and Wales in September 2006. Following a critical House of Commons report in 2002, the government altered the National Curriculum targets and thus forced the Examination Boards to alter their specifications in order to come in line. Assessment at GCSE level (i.e., the 14-16 year cohort) was criticised for: a) failing to inspire students to continue with science, b) discouraging students from thinking for themselves, c) neglecting contemporary science, d) lacking flexibility, and e) making practical work into a tedious and dull activity. The British government has insisted that all pupils in state funded schools must know the names of some modern scientists and their work. They must discuss some current scientific problems. History and philosophy of science is included under the topic heading “How Science Works.” In Chemistry these objectives have destroyed the traditional linear top-down sequential approach of teaching into an approach based more closely on Whiteheadean lines (cf., the ideas expressed in The Aims of Education, 1926, Chapters 1-3).     

Random vibration analysis of switching apparatus based on Monte Carlo method

The performance in vibration environment of switching apparatus containing mechanical contact is an important element when judging the apparatus’s reliability. A piecewise linear two-degrees-of-freedom mathematical model considering contact loss was built in this work, and the vibration performance of the model under random external Gaussian white noise excitation was investigated by using Monte Carlo simulation in Matlab/Simulink. Simulation showed that the spectral content and statistical characters of the contact force coincided strongly with reality. The random vibration character of the contact system was solved using time (numerical) domain simulation in this paper. Conclusions reached here are of great importance for reliability design of switching apparatus.     

Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells

Homoharringtonine (HHT) has currently been used successfully in the treatment of acute and chronic myeloid leukemias and has been shown to induce apoptosis of different types of leukemic cells in vitro. Emerging evidence suggests that angiogenesis may play an important role in hematological malignancies, such as leukemia. How ever, whether HHT can relieve leukemia by anti-angiogenesis is still unknown. We investigated the anti-angiogenesis potential of HHT with the human umbilical vein endothelial cell line (ECV304) and leukemic cell line (K562) in vitro. Cellular proliferation was determined by MTT assay and apoptosis was analyzed by flow cytometry. The mRNA expression of vascular endothelial growth factor (VEGF) was assessed by RT-PCR and VEGF protein production was detected by Western blot. Inhibition of cell proliferation and induction of apoptosis by HHT were discovered in ECV304 cells, and appeared in a dose- and time-dependent manner. Also, treatment with HHT caused down-regulation of VEGF mRNA expression in K562 cells in similar dose- and time-dependent manner and inhibition of VEGF protein production in K562 cells in response to the enhancing concentration of HHT. The results demonstrated that HHT could also induce apoptosis in endothelium and down-regulate VEGF expression in K562 cells. In conclusion, we believe HHT has anti-angiogenesis potential and speculate that HHT might exert its anti-leukemia effects via reduction of angiogenesis.