On-chip actuation transmitter for enhancing the dynamic response of cell manipulation using a macro-scale pump

An on-chip actuation transmitter for achieving fast and accurate cell manipulation is proposed. Instead of manipulating cell position by a directly connected macro-scale pump, polydimethylsiloxane deformation is used as a medium to transmit the actuation generated from the pump to control the cell position. This actuation transmitter has three main advantages. First, the dynamic response of cell manipulation is faster than the conventional method with direct flow control based on both the theoretical modeling and experimental results. The cell can be manipulated in a simple harmonic motion up to 130 Hz by the proposed actuation transmitter as opposed to 90 Hz by direct flow control. Second, there is no need to fill the syringe pump with the sample solution because the actuation transmitter physically separates the fluids between the pump and the cell flow, and consequently, only a very small quantity of the sample is required (<1 μl). In addition, such fluid separation makes it easy to keep the experiment platform sterilized because there is no direct fluid exchange between the sample and fluid inside the pump. Third, the fabrication process is simple because of the single-layer design, making it convenient to implement the actuation transmitter in different microfluidic applications. The proposed actuation transmitter is implemented in a lab-on-a-chip system for red blood cell (RBC) evaluation, where the extensibility of red blood cells is evaluated by manipulating the cells through a constriction channel at a constant velocity. The application shows a successful example of implementing the proposed transmitter.     

Effect of combined carbohydrate-protein ingestion on markers of recovery after simulated rugby union match-play

In this study, we investigated the effect of ingesting carbohydrate alone or carbohydrate with protein on functional and metabolic markers of recovery from a rugby union-specific shuttle running protocol. On three occasions, at least one week apart in a counterbalanced order, nine experienced male rugby union forwards ingested placebo, carbohydrate (1.2 g · kg body mass(-1) · h(-1)) or carbohydrate with protein (0.4 g · kg body mass(-1) · h(-1)) before, during, and after a rugby union-specific protocol. Markers of muscle damage (creatine kinase: before, 258 ± 171 U · L(-1) vs. 24 h after, 574 ± 285 U · L(-1); myoglobin: pre, 50 ± 18 vs. immediately after, 210 ± 84 nmol · L(-1); P < 0.05) and muscle soreness (1, 2, and 3 [maximum soreness = 8] for before, immediately after, and 24 h after exercise, respectively) increased. Leg strength and repeated 6-s cycle sprint mean power were slightly reduced after exercise (93% and 95% of pre-exercise values, respectively; P < 0.05), but were almost fully recovered after 24 h (97% and 99% of pre-exercise values, respectively). There were no differences between trials for any measure. These results indicate that in experienced rugby players, the small degree of muscle damage and reduction in function induced by the exercise protocol were not attenuated by the ingestion of carbohydrate and protein.     

Effects of a Developmentally Based Intervention With Teachers on Native American and White Early Adolescents’ Schooling Adjustment in Rural Settings

This study reports the effectiveness of a developmentally based, teacher professional development intervention aimed at improving early adolescent school adjustment. Teachers in rural schools in a Northern Plains state took part in professional development activities across a year. Following a randomized control trial design, Native American and White students’ (N = 165) social, behavioral, and academic adjustment was assessed in intervention compared with control schools. Regression analyses, controlling for baseline and demographic variables, indicated that students in intervention schools improved in achievement, and improved or sustained beginning-of-year schooling dispositions, and perceptions of the school social/affective context, in comparison with evident declines for students in control schools. Native American students more so than White students evidenced particular gains in achievement and perceptions of the school social/affective context.     

Variability of Physical Activity Patterns by Type of Day and Season in 8-10-Year-Old Boys

Abstract

The purposes of this study were to generate correction equations for self-reported height and weight quartiles and to test the accuracy of the body mass index (BMI) classification based on corrected self-reported height and weight among 739 male and 434 female college students. The BMIqc (from height and weight quartile-specific, corrected self-reported measurements) provided a more accurate estimation of BMI classification than BMIc (from corrected self-reported measurements) and BMIs (from self-reported measurements) by showing a greater ability to predict cases with either a high or a low BMI category while still maintaining a high specificity. However, the equations are applicable only to Caucasian college student populations, so cross-validation in similar populations is needed before they are used more broadly.     

Combination,Aggregation and Reconciliation: evidential and consequential bases

In educational assessment, it is widely assumed that (possibly weighted) addition of scores achieved on individual items is the most appropriate method of deriving a single domain score. However, the inferences that can be drawn from such combined scores are often quite limited, because strength in one area can compensate for weakness in others. For this reason, during the development of assessments for the National Curriculum of England and Wales, a variety of innovative methods of combination have been proposed. A classification of combination schemes is presented, which analyses combination schemes in terms of both the inferences that are possible from the combined scores, and the possible consequences of the use of such schemes. In particular, it is shown that some combination schemes (termed manipulable) create incentives for teachers to treat different students in different ways (although whether teachers then do so is a much more complex issue). An index of manipulability is proposed and estimates of the index are presented for eight combination schemes.     

An Evaluation of the Effectiveness and Acceptability of Teleconsultation

School-based psychological services are typically provided through a triadic model of consultation in which a school psychologist works directly with a teacher or school staff member to address the academic, behavioral, or mental health concerns of a student. With advances in current technology, school psychologists have the capacity to use videoconferencing to engage in their consultative responsibilities. Teleconsultation has the potential to improve the provision of consultative services by increasing school psychologists’ efficiency and providing individuals, especially those in rural areas, access to greater service. The current study evaluated the effectiveness and acceptability of teleconsultation as a means to deliver behavioral consultation services to three teachers and their students. A nonconcurrent multiple baseline across subjects was used. Results showed that consultants could develop a behavioral intervention with a teacher and effectively implement the intervention to improve student outcomes. Teachers also rated teleconsultation as an acceptable means for service delivery.     

The media of high-resolution time: Temporal frequencies as infrastructural resources

This article offers a short history of the transformation of time signals into a fundamental stability around which new communication infrastructures are built. These infrastructures include the Network Time Protocol, the Global Positioning System, and high-frequency trading. This article argues that “high-resolution time” can serve as a useful analytic framework for understanding the making and appropriation of contemporary temporal standards. Contemporary temporal infrastructures—the systems of time measurement and dissemination that subtend communication infrastructures—are based on the vibrations of caesium atoms, which act as fixed points. A focus on resolution aligns an analysis with the ways that time standards are, in practice, treated as both infrastructures and texts. High-resolution time, therefore, offers an understanding of time as a scalable resource built through contingent media practices.     

Start‐up Mega Planning—A Case History

ABSTRACT Social Responsibility is becoming a key issue for organizations today. They talk about it and they make social contributions, but how do we know if anything is being achieved? A framework is required and has existed at least since 1992. Roger Kaufman's Mega Planning has slowly gathered momentum in organizations worldwide. For a faster take‐up we propose Start‐up Mega Planning. This uses Kaufman's original model, which is more easily communicated, and fast tracks any organization into much of the benefits of Mega: stakeholder involvement, innovative approach, improved client relations and success beyond “sustainability.” Australian case history shows the simplicity this brings to planning, and the benefits of having all stakeholders aligned. In addition, the more sophisticated Mega model awaits as the next step, with further benefits.     

Running patterns for male and female competitive and recreational runners based on accelerometer data

The purpose of this study was to classify runners in sex-specific groups as either competitive or recreational based on center of mass (CoM) accelerations. Forty-one runners participated in the study (25 male and 16 female), and were labeled as competitive or recreational based on age, sex, and race performance. Three-dimensional acceleration data were collected during a 5-minute treadmill run, and 24 features were extracted. Support vector machine classification models were used to examine the utility of the features in discriminating between competitive and recreational runners within each sex-specific subgroup. Competitive and recreational runners could be classified with 82.63 % and 80.4 % in the male and female models, respectively. Dominant features in both models were related to regularity and variability, with competitive runners exhibiting more consistent running gait patterns, but the specific features were slightly different in each sex-specific model. Therefore, it is important to separate runners into sex-specific competitive and recreational subgroups for future running biomechanical studies. In conclusion, we have demonstrated the ability to analyze running biomechanics in competitive and recreational runners using only CoM acceleration patterns. A runner, clinician, or coach may use this information to monitor how running patterns change as a result of training.