Modular microfluidic system as a model of cystic fibrosis airways

A modular microfluidic airways model system that can simulate the changes in oxygen tension in different compartments of the cystic fibrosis (CF) airways was designed, developed, and tested. The fully reconfigurable system composed of modules with different functionalities: multichannel peristaltic pumps, bubble traps, gas exchange chip, and cell culture chambers. We have successfully applied this system for studying the antibiotic therapy of Pseudomonas aeruginosa, the bacteria mainly responsible for morbidity and mortality in cystic fibrosis, in different oxygen environments. Furthermore, we have mimicked the bacterial reinoculation of the aerobic compartments (lower respiratory tract) from the anaerobic compartments (cystic fibrosis sinuses) following an antibiotic treatment. This effect is hypothesised as the one on the main reasons for recurrent lung infections in cystic fibrosis patients.     

Student Communication Motives and Interpersonal Attraction Toward Instructor

Instructional communication research has not specifically focused on the impact of student classroom communication behaviors on the student-teacher relationship. The current study investigated the relationship between student motives to communicate with instructors and interpersonal attraction toward them. Canonical correlation results indicated student levels of physical, social, and task attraction were positively related to their motivation to establish a relationship, and expressing interest in class and task attraction was inversely related to participatory, excuse-making, and sycophantic motives. Regression analyses determined students' relational motivations as the greatest predictor of social and physical attraction, while excuse-making was the greatest predictor of task attraction.     

Techniques and considerations for determining isoinertial upper-body power

Power is an integral aspect of many sports. Although power output of the lower body is often measured during jumping and cycling movements, much less is known about power as pertains to the upper body musculature. Recently, isoinertial methods--with constant gravitational load--of power testing have become common, but little is known of the reliability and criterion validity of these tests as they pertain to sport performance. In addition, the varied methodology makes a lucid model more evasive. The aims of this review are to examine the various methods of assessing upper body power, to establish its role in predicting athletic performance, and to assess the body of literature that has assessed power output of the upper extremities by isoinertial methods. To our knowledge, only two studies on isoinertial upper-body power have shown a direct correlation to sporting ability (Baker, 2001; Baker et al., 2001); therefore, many unanswered questions exist as to the efficacy of these tests as predictors of athletic ability or as a method to track athletes' training over time. From this review we hope to allow the sport coach to assess the overall utility of these tests in terms of availability, safety and external validity.     

The locus of focus: the effect of switching from a preferred to a non-preferred focus of attention

Focusing strategies are known to play a significant role in motor performance, with individuals who use an internal focus on body movement typically showing poorer outcomes than those who focus on features of the external environment. Focus of attention and switching of one's focus are examined in the context of two different complex motor skills along with a factor not previously examined systematically, individual preference. In both experiments, participants were introduced to focusing strategies that might be employed when attempting a sensorimotor task. Explanations of both strategies were given to participants. Specifically, for an internal focus, participants were instructed to concentrate on their body movements, while for an external focus, they were instructed to focus on aspects in the environment. They were then asked which strategy they preferred. Participants then continued either with their preferred focus or were instructed to switch to their non-preferred focus. The advantage that the external focus typically enjoys turns out not to be a simple one and interacts with individual preference and with the "forced-opposite" manipulation. Our results support the growing consensus that encouraging individuals to adopt an internal focusing strategy is counterproductive in complex sensorimotor tasks. They also suggest that individual preferences play a role.     

A practical approach to making accurate 3D layouts of interesting cultural heritage sites through digital models

On many occasions, the graphic information handled by people working in the cultural heritage sector is still bidimensional. Layouts showing elevations and cross sections are the most widespread tools. However, there is an increased need for carefully detailing the complexity of valuable sites with an improved accuracy. This implies the measuring and handling of three-dimensional data, using both commercial and turn-key hardware and software solutions. Taking the usual traditional process as a reference, in the present paper a new effective methodology for carrying out computer assisted delineation of layouts from cultural heritage sites, using 3D digital models, is described. The proposed procedure has been tested in five intervention projects on representative churches within the “Merindad de Aguilar de Campoo” medieval area, in the north of Spain.¹ This area has the largest collection of Romanesque art in the world, and is currently under European Heritage Site and World Heritage Site declaration process by the UNESCO.     

"Show and tell" in the gymnasium revisited: developmental differences in modeling and verbal rehearsal effects on motor skill learning and performance.

Little research has investigated the observational learning process from a developmental perspective. The purpose of this study was to extend previous research by considering two factors: performance versus learning and sequencing versus form scores. Children (N = 60) comprising two age groups (5-0 to 6-11 and 8-0 to 9-11 years) were randomly assigned to verbal rehearsal only, model only, or model plus verbal rehearsal conditions. The task was a 6-part motor skill sequence in which proper sequencing and quality of form were assessed. A 2 x 3 x 4 (age group by model type by trial blocks) repeated measures MANOVA revealed a significant three-way interaction. Older children performed equally well under any of the model type conditions during both performance and learning. For younger children, a model plus rehearsal was superior to rehearsal only on sequence and form at performance and learning and superior to model only on sequence scores during the first two performance trial blocks. Model only and model plus rehearsal conditions were equally effective on form scores. These results suggest that age differences exist in the modeling of motor skills under conditions varying in model type, sequence and form scores, and performance and learning phases.