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101.
Rhema Elizabeth Thomas Ajaikumar Sukumaran Arun Krishnan R Thushara Thomas Biby T Edwin P R Haritha Bilha M Varghese Jofy K Paul Satheesh Kumar C S D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2023,38(1):51
The vaccination efficacy can indirectly be assessed through the quantification of neutralizing antibodies. Very few data are available on Covishield efficacy in terms of neutralizing antibody expression upon vaccination. This study is focused on profiling of neutralizing antibody expression during and after the Covishield two shot vaccination and observing COVID-19 infection in vaccinated participants during the period. SARS CoV-2 neutralizing antibody concentrations in samples were estimated using electrochemiluminescence immunoassay kit for Lifotronics eCL8000. The sampling had been done sequentially at 45th, 85th day after 1st dose and 15th day after 2nd dose Covishield vaccination. Parallelly, in order to confirm the total SARS CoV-2 IgG response in COVID-19 infection, measured the IgG using SARS CoV-2 IgG lateral flow immunoassay test kit. The subjects previously infected with COVID-19 before 1st dose vaccination demonstrated high neutralizing antibody (> 10AU/ml). In COVID-19 uninfected subjects, there was a sudden incline in neutralizing antibody after the 2nd dose. Infection with SARS CoV-2 between 1st and 2nd dose of Covishield vaccination implicate that the level of neutralizing antibody in serum after 1st dose was not adequate to combat the virus and prevent infection. We observed COVID-19 infection in participants even after 2nd dose of vaccination. Interestingly, there was no protection against SARS CoV-2 even with a high neutralizing antibody expression of 188.5 AU/mL after the 2nd dose. Findings of Covishield efficacy in different cohort samples before and after 2 doses of Covishield vaccination provide impetus for improvement or development of next generation vaccines. 相似文献
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Edwin L. Cooper Ph.D. 《Endeavour》1980,4(4):160-165
The life of animals can be sustained only if the cellular environment can be closely controlled. Elaborate processes have, therefore, been evolved to detect and eliminate foreign material in the body, including tumour cells. An understanding of these processes is of great medical importance. This article reviews current ideas of how defence mechanisms have developed during the evolution of mammals from primitive ancestors. 相似文献
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Edwin L. Herr Norman E. Amundson William A. Borgen 《International journal for the advancement of counseling》1990,13(4):295-313
In Europe and in North America, the creation of new economic alliances that are boundary free for corporations and workers in the nations involved will stimulate new needs for counseling. Planning for counseling to deal with the individual needs caused by economic boundary shifting should encompass two broad themes: (1) the likely psychological dynamics of boundary changing; and (2) the possible effects of boundary changing on the structure and choice of and planning for occupations.As economic structures change, counselors and counseling will need to address the resulting transformations of the psychological environments, the sets of behavioral expectations, the national mythologies and social metaphors in which persons negotiate their identities, find their sources of self-validation and pursue a career. The counselors will need to be prepared to deal with the stresses and anxieties that accompany such change as well as the threats to cultural identity that accompany worker migration from nations of origin. Assisting workers to deal with evolving skill requirements from new technologies, cultural transitions, retraining, underemployment, and unemployment will become increasingly important aspects of the counselor's agenda.The Pennsylvania State University and The University of British Columbia 相似文献
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Summary A sample school population of 75 family units of equal size was investigated for expression of specific reading disability.
25.3% of the total children showed specific reading disability as defined in this study. By using spelling achievement as
the criterion for the presence of the disability, the incidence of the disorder was shown to be much higher in certain families
than in others, with clear sibling aggregation. The siblings of specific-reading-disability cases demonstrated lower spelling
competence than the total siblings in normal families, even when well above a crippling level. Both within individual families
and by grades, the spelling rating in relation to grade norms of the specific-reading-disability family cases with their siblings
tended to decline with age, in contrast to normal families where it tended to improve with age. This pattern was even more
striking if the greater language competence of females, now quite generally accepted and further supported by this study,
was taken into account. It was demonstrated that the above patterns were not primarily a product of intelligence level or
teaching methods. The bearing of these findings on the tenability of the most common, current hypotheses concerning causation
was briefly discussed.
From the Language Clinic and Division of Neurology, Massachusetts General Hospital. 相似文献
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