Beyond the Central Dogma: Model-Based Learning of How Genes Determine Phenotypes

In an introductory biology course, we implemented a learner-centered, model-based pedagogy that frequently engaged students in building conceptual models to explain how genes determine phenotypes. Model-building tasks were incorporated within case studies and aimed at eliciting students’ understanding of 1) the origin of variation in a population and 2) how genes/alleles determine phenotypes. Guided by theory on hierarchical development of systems-thinking skills, we scaffolded instruction and assessment so that students would first focus on articulating isolated relationships between pairs of molecular genetics structures and then integrate these relationships into an explanatory network. We analyzed models students generated on two exams to assess whether students’ learning of molecular genetics progressed along the theoretical hierarchical sequence of systems-thinking skills acquisition. With repeated practice, peer discussion, and instructor feedback over the course of the semester, students’ models became more accurate, better contextualized, and more meaningful. At the end of the semester, however, more than 25% of students still struggled to describe phenotype as an output of protein function. We therefore recommend that 1) practices like modeling, which require connecting genes to phenotypes; and 2) well-developed case studies highlighting proteins and their functions, take center stage in molecular genetics instruction.     

Going, going, gone. Exit forms and the innovative capabilities of firms

Although innovation is essential to build a competitive advantage and survive in the long run, some firms choose to exit, through mergers and acquisitions (M&As), or radically change their business portfolio and identity. This paper examines how innovative capabilities influence the decision of a firm to exit, among business closure, M&A, and radical restructuring. Using an analysis of a large and rich panel of Dutch manufacturing firms, we find that product and process innovation are equally important to lower the probability to close down activities, and this effect is stronger when product and process innovations are pursed in combination. We also find that process innovation reduces the probability of exit by radical restructuring, while product innovation, when not supported by process innovation, especially increases the probability of exit by M&As. Our findings suggest that exit strategies are intimately bound to the nature and synergies of innovative efforts.     

“So it Takes Extra Time and Effort,Pero, Vale la Pena”: A Bilingual Teacher’s Testimonio Revealing Pedagogical Clarity

The Urban Review - This testimonio examines how a 3rd grade bilingual teacher unpacks the learning process as it relates to her agency in implementing culturally relevant (Ladson-Billings, Am Educ...     

Effects of added elastic tubes on open-chain knee extensor strength training

Attaching elastic tubes (ETs) to resistance training machines can affect the exercise load profile. The purpose of this study was to assess the training effects of added ETs, which were strategically attached to provide additional loads only during the deceleration phase of the knee extension exercise. Twenty-two healthy participants, assigned to either an experimental group (with ETs) or a control group (without ETs), participated in a 12-week strength-training program using a knee extension exercise machine. The acceleration effects were quantified and a method of attaching the ETs to the knee extension machine was developed. The effects of the added ETs were analysed by testing dynamic and isometric maximum contractions at four knee flexion angles (10°, 30°, 50°, and 80°). Analyses of covariance with the initial values as the covariate were used to examine the ET effects. A greater increase in isometric maximum strength was found in the experimental group than in the control group at knee flexion angles of 10° [effect size (ES) = 2.25] and 30° (ES = 1.18). No significant difference in the dynamic maximum strength was found between the groups. The use of ETs increased strength at smaller knee flexion angles with quadriceps that were relatively short.     

The involvement of school teachers in research‐related activities: Extent,quality and predictors

In view of the need to develop school teachers as research‐oriented professionals and the reported complexities of this endeavour internationally, this article explores teacher involvement in research‐related‐activities in Cyprus. It aims to measure the extent and quality of such involvement and explore possible predictors. Data were collected from a sample of 420 public primary and secondary school teachers. Most respondents reported involvement in activities for the consumption of research, which was found to be related to teachers' background in research methods courses and work context (primary/secondary school). Teachers' involvement in activities for the production of research was less extensive, whilst statistical associations with the specific background variables were not traced. On the basis of the findings, recommendations for the transition towards research‐oriented teachers are discussed in terms of developing research knowledge, skills and attitudes and providing supportive measures to schools.     

The Effectiveness of Teaching Geometry to Enhance Mathematical Understanding in Children with Down Syndrome

ABSTRACT

It is widely known that people with Down syndrome have difficulties transitioning from a basic understanding of counting and cardinality to more advanced arithmetic skills. This is commonly addressed by resorting to the mechanical use of algorithms, which hinders the acquisition of mathematical concepts. For this reason some authors have recently proposed a shift in the focus of learning from arithmetic to more fertile fields, in terms of understanding. In this paper we claim geometry fits this profile, especially suited for initiating children with Down syndrome into mathematics. To support this we resort to historical, epistemological, and cognitive reasons: the work of Séguin and his intuition on the central role of geometry in the development of abstract thinking in the so-called idiot children, the ideas of René Thom about the role of continuum intuition in the emergence of conscious thinking, and finally the two strengths people with Down syndrome display: visual learning abilities and interest in abstract symbols. To support these ideas we present the main findings of qualitative research on elementary mathematics teaching to a group of seven children (3–8) with Down syndrome in Spain. The didactic method used, naturally enhance their naïve geometrical conceptions.     

Checking the possibility of equating a mathematics assessment between Russia,Scotland and England for children starting school

Is it possible to compare the results in assessments of mathematics across countries with different curricula, traditions and age of starting school? As part of the iPIPS project, a Russian version of the iPIPS baseline assessment was developed and trial data were available from about 300 Russian children at the start and end of their first year at school. These were matched with parallel data from representative samples of equal numbers of children from England and Scotland. The equating of the scales was explored using Rasch measurement. A unified scale was easiest to create for England and Scotland at the start and end of their first year at school when children only differ by a half a year in age, and live in adjacent countries with a common language. Although fewer items showed invariance across the three countries, it was possible to link iPIPS scores in mathematics from the start and end of the first year at school across Scotland, England and Russia. The findings of this study suggest that, despite the apparent difficulties, meaningful comparisons of mathematics attainment and development can be made. These will allow for substantive interpretations with policy implications.     

The Development of a New Measure of Pupils' Self-Esteem in Singapore Secondary Schools

This article is a brief account of the development of a new measure of pupils' self-esteem for use in Singapore's secondary schools. The new measure named “Self-Esteem Checklist” (SEC), is a self-reporting instrument comprising 25 items grouped under 4 subscales. It has been pilot tested twice (in September 1986 and March 1987), before the main study was conducted in May, 1987. The findings of the second pilot study and main study yield support to the validity and reliability of the SEC, and its correlation with pupils' academic achievement. This instrument, when used with proper guidance, may facilitate teacher-counsellors' understanding of pupils' self-esteem, and help pupils know more about themselves, in the pastoral care as well as career guidance programmes.     

Using the theory of successful intelligence as a basis for augmenting AP exams in Psychology and Statistics

Sternberg’s theory of successful intelligence was used to create augmented exams in Advanced Placement Psychology and Statistics. Participants included 1895 high school students from 19 states and 56 schools throughout the U.S. The psychometric results support the validity of creating examinations that assess memory, analytical, creative, and practical skills in the context of content-specific knowledge. In addition, Q-factor analyses revealed a set of empirically distinguishable profiles of achievement, supporting the assertion that individuals exhibit different patterns of strengths and weaknesses in cognitive processing skills. Finally, an examination of ethnic group differences in achievement shows that measuring a broad range of cognitive skills tends to reduce ethnic differences in achievement. Future studies aimed at replicating these findings are warranted.