ABSTRACTMoving beyond the dominant bag-of-words approach to sentiment analysis we introduce an alternative procedure based on distributed word embeddings. The strength of word embeddings is the ability to capture similarities in word meaning. We use word embeddings as part of a supervised machine learning procedure which estimates levels of negativity in parliamentary speeches. The procedure’s accuracy is evaluated with crowdcoded training sentences; its external validity through a study of patterns of negativity in Austrian parliamentary speeches. The results show the potential of the word embeddings approach for sentiment analysis in the social sciences. 相似文献
Drug discovery is an expensive and lengthy process. Among the different phases, drug discovery and preclinical trials play an important role as only 5–10 of all drugs that begin preclinical tests proceed to clinical trials. Indeed, current high-throughput screening technologies are very expensive, as they are unable to dispense small liquid volumes in an accurate and quick way. Moreover, despite being simple and fast, drug screening assays are usually performed under static conditions, thus failing to recapitulate tissue-specific architecture and biomechanical cues present in vivo even in the case of 3D models. On the contrary, microfluidics might offer a more rapid and cost-effective alternative. Although considered incompatible with high-throughput systems for years, technological advancements have demonstrated how this gap is rapidly reducing. In this Review, we want to further outline the role of microfluidics in high-throughput drug screening applications by looking at the multiple strategies for cell seeding, compartmentalization, continuous flow, stimuli administration (e.g., drug gradients or shear stresses), and single-cell analyses. 相似文献
The purpose of this study was to investigate the effects of interval aerobic training combined with strength exercise in the same training session on body composition, and glycaemic and lipid profile in obese rats. Sixteen lean Zucker rats and sixteen obese Zucker rats were randomly divided into exercise and sedentary subgroups (4 groups, n = 8). Exercise consisted of interval aerobic training combined with strength exercise in the same training session. The animals trained 60 min/day, 5 days/week for 8 weeks. Body composition, lipid and glycaemic profiles and inflammatory markers were assessed.
Results showed that fat mass was reduced in both lean and obese rats following the exercise training (effect size (95% confidence interval (CI)) = 1.8 (0.5–3.0)). Plasma low-density lipoprotein–cholesterol and fasting glucose were lower in the exercise compared to the sedentary groups (d = 2.0 (0.7–3.2) and 1.8 (0.5–3.0), respectively). Plasma insulin was reduced in exercise compared to sedentary groups (d = 2.1 (0.8–3.4)). Some exercise × phenotype interactions showed that the highest decreases in insulin, homeostatic model assessment-insulin resistance, fasting and postprandial glucose were observed in the obese + exercise group (all, P < 0.01). The findings of this study suggest that interval aerobic training combined with strength exercise would improve body composition, and lipid and glycaemic profiles, especially in obese rats. 相似文献
ABSTRACT The aim of this article is to examine how EU lifelong learning policies are trying to reach the vulnerable by looking at what measures against social exclusion they offer and how equitable these measures are. It is a qualitative study that focuses on policy documents that form the European Union’s legal and political frameworks of reference in the lifelong learning area since 1992. The document analysis has been complemented by semi-structured interviews with EU lifelong learning experts. The findings show that early school leavers and migrants are the main target groups in the policies, leaving many other groups at risk of being excluded from learning opportunities. There is not enough attention to measures addressing wider social phenomena. There is also an overemphasis on basic skills which are understood in a very narrow way as literacy and numeracy when referring to the vulnerable. We argue that a greater variety of measures as well as better targeted measures are needed to address the multiple and complex needs of the vulnerable. Such measures would allow a broader understanding of lifelong learning where those that are hardest to reach are offered learning opportunities independent of their personal and social circumstances 相似文献
Rapid globalization of business processes stimulates many companies to dispatch their employees – business expatriates – on overseas assignments. Russia differs markedly from many other cultures in terms of specific communication norms and rules. Understanding such differences in organizational life is crucial for the success of business expatriates working there. This study employs in-depth interviews with eight Danish business expatriates who worked in Russia and examines the differences between the Danes and the Russians in terms of communication characteristics related to Hofstede’s cultural dimension power distance. This work enhances scholars’ empirical knowledge of power distance, which has rarely been investigated qualitatively. 相似文献
Two mechanisms have been suggested to explain stretching-induced maximum force depression: a mechanical alteration in the stretched muscle and an impairment of neural activation. Electrical stimulation allows standardization of the level of muscle activation without being limited by neural control. The aim of this study was to evaluate the stretching-induced changes in the electrical and mechanical properties of muscle during electrically elicited contractions. Twelve participants (age 22 +/- 1 years; body mass 75 +/- 2 kg; stature 1.79 +/- 0.02 m; mean +/- standard error) underwent six electrical stimulations of the medial gastrocnemius muscle before and after stretching. During the contractions, surface electromyogram (EMG) and mechanomyogram (MMG) were recorded simultaneously together with force. After stretching we found: (i) no differences in EMG parameters; (ii) MMG amplitude decreased by 4 +/- 1% (P < 0.05); and (iii) the peak force, the peak rate of force development, and the acceleration peak of force development decreased by 12 +/- 3%, 14 +/- 1%, and 24 +/- 5%, respectively (P < 0.05). In conclusion, acute passive stretching did not change EMG properties but altered the mechanical characteristics of the contracting muscle. Indeed, muscle force-generating capacity and stiffness of the muscle-tendon unit were significantly impaired. 相似文献
Tackling in Rugby Union is an open skill which can involve high-speed collisions and is the match event associated with the greatest proportion of injuries. This study aimed to analyse the biomechanics of rugby tackling under three conditions: from a stationary position, with dominant and non-dominant shoulder, and moving forward, with dominant shoulder. A specially devised contact simulator, a 50-kg punch bag instrumented with pressure sensors, was translated towards the tackler (n = 15) to evaluate the effect of laterality and tackling approach on the external loads absorbed by the tackler, on head and trunk motion, and on trunk muscle activities. Peak impact force was substantially higher in the stationary dominant (2.84 ± 0.74 kN) than in the stationary non-dominant condition (2.44 ± 0.64 kN), but lower than in the moving condition (3.40 ± 0.86 kN). Muscle activation started on average 300 ms before impact, with higher activation for impact-side trapezius and non-impact-side erector spinae and gluteus maximus muscles. Players’ technique for non-dominant-side tackles was less compliant with current coaching recommendations in terms of cervical motion (more neck flexion and lateral bending in the stationary non-dominant condition) and players could benefit from specific coaching focus on non-dominant-side tackles. 相似文献
The present paper provides a qualitative and quantitative approach to natural lighting design for the Hall of Two Hundred in Palazzo Vecchio (the present town hall) in Florence. Starting from transient simulation of natural lighting inside the Hall in its present state, using the commercial software Radiance, a design proposal was suggested, detecting the optimal conditions for tapestry conservation and maintenance and taking into account their periodical exhibition, designing a proper wall show-case solution. The suggested design does not modify the architecture and structure of the building. The distribution of natural lighting and consequently of the illuminance and luminance inside the ambient, suggested a solution for exhibition of the historical tapestries, which can guarantee not only tapestry conservation but also the Hall structure and its present uses. The design proposal provides a comfortable lighting environment, rehabilitation and improvement of the historical perception and sight of these works of art, under variable sun and sky conditions throughout the year. 相似文献