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Duchenne Muscular Dystrophy (DMD) is a neurogenetic developmental disorder that presents with progressive muscular weakness. It is caused by a mutation in a gene that results in the absence of specific products that normally localize to muscle cells and the central nervous system (CNS). The majority of affected individuals have IQs within the normal range, generally with lower verbal than performance IQ scores. Prior work has demonstrated selective deficits on tests of verbal span and immediate memory. For the current study, 26 boys with DMD (and normal intellectual function) and their unaffected siblings were evaluated. Paired comparisons demonstrated that the children with DMD had significantly poorer academic achievement scores than their siblings, even though their vocabulary levels and home and educational environments were comparable. Children with DMD also had more behavioral concerns, physical disabilities, and poorer verbal memory spans. Linear regression indicated that behavioral concerns, executive function, and physical disability did not contribute substantially to academic performance, whereas performance on verbal span did. DMD presents with a selective developmental aberration in verbal span that has wide‐ranging consequences on learning skills.  相似文献   
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本文要点: ◆遗传型是机体全部遗传基因的总和,代表了个体的遗传潜力.在决定个体的解剖、生化、生理、行为等特性或遗传表型(如褐色的眼睛、75kg的体重、50 ml/kg/min的最大摄氧量等)上起主导作用.  相似文献   
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The article sets off with a brief summary of the history of appraisal and disposal of records as processed at the National Archives of Iceland (NAI) since its establishment in 1882 to present times. Rules on appraisal and disposal of records introduced in 1900, 1911, and 1916 were ignored and all records were kept. Status quo remained until 1985 when a new National Archives Act was passed. The appraisal and disposal process adopted then is described and explained. It included the publication of instructions on records management as well as forms relating to records management. The influence of acts of law on the appraisal and disposal process is explained. Finally the experience with the arrangement of organised appraisal in Iceland is described.  相似文献   
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Evidence shows that initial and advanced learning to read are predominantly mediated by the right and left cerebral hemispheres, respectively. Premature reliance on left-hemispheric reading strategies may result in L-type dyslexia, characterized by hurried and inaccurate reading. P-type dyslexia, characterized by a slow and fragmented style of reading, may result from the inability to shift from the predominant generation of right-hemispheric reading strategies to the predominant generation of left-hemispheric reading strategies. Results of investigations concerning the validity of the L/P-typology are discussed, as are the reading effects of hemisphere-specific and hemisphere-alluding stimulation in children with L- and P-type dyslexia.  相似文献   
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