Impact of combining data from multiple instruments on performance of patient-based real-time quality control

IntroductionIt is unclear what is the best strategy for applying patient-based real-time quality control (PBRTQC) algorithm in the presence of multiple instruments. This simulation study compared the error detection capability of applying PBRTQC algorithms for instruments individually and in combination using serum sodium as an example.Materials and methodsFour sets of random serum sodium measurements were generated with differing means and standard deviations to represent four simulated instruments. Moving median with winsorization was selected as the PBRTQC algorithm. The PBRTQC parameters (block size and control limits) were optimized and applied to the four simulated laboratory data sets individually and in combination.ResultsWhen the PBRTQC algorithm were individually optimized and applied to the data of the individual simulated instruments, it was able to detect bias several folds faster than when they were combined. Similarly, the individually applied algorithms had perfect error detection rates across different magnitudes of bias, whereas the error detection rates of the algorithm applied on the combined data missed smaller biases. The performance of the individually applied PBRTQC algorithm performed more consistently among the simulated instruments compared to when the data were combined.DiscussionWhile combining data from different instruments can increase the data stream and hence, increase the speed of error detection, it may widen the control limits and compromising the probability of error detection. The presence of multiple instruments in the data stream may dilute the effect of the error when it only affects a selected instrument.     

提心吊胆的华尔街

The war in Iraq, terrorism, rising oil prices-and now the threat of higher interest rates-are all preying on the market. There comes a point in virtually every bull market when     

Differential contribution of psycholinguistic and cognitive skills to written composition in Chinese as a second language

Reading and Writing - This study examined the contribution of the constructs of orthographic processing (orthographic choice and orthographic choice in context), syntactic processing...     

从孟、荀看战国儒家政治文化之演进

孟子与荀子的政治观从表面上看大多是对立的，但在实际上并不矛盾，他们往往说的不是一个层面上的问题。就其政治大思路而言，二者是一致的，都倡导人治，都是道德主义的，有其“同归而殊途”的内在逻辑。     

Examining Teachers' Use of iPads: Comfort Level,Perception, and Use

While there is evidence of the growing popularity of iPads and other tablets in K–12 education, little is understood about how teachers use these devices in their instruction. This study examines 342 teachers' comfort level with and perception toward iPad use and any changes that occurred over the implementation year. Using a mixed-methods design, this study found significant differences in comfort level by years of teaching and school levels. Female teachers, teachers with 20 years or less of teaching experience, and elementary school teachers were more positive about their perception toward iPad use than the other groups. High school teachers' perception was the lowest overall. Analyses of teacher interviews revealed affordances, challenges, and diverse ways of how teachers used iPads in their instruction. Implications for practice and research are discussed.     

The use of microcomputer technology in a modular approach to reading and reading difficulties

This paper outlines the theoretical framework of a two-year two cohort study of inter-related modules to model reading in 300 grades 4, 5 and 6 readers, and describes the specially designed microcomputer programs written in Turbo Pascal to implement this modular approach. In brief, the modular approach postulates the interrelated phonological, morphological modules in processing words and sentence/paragraph processing. These three modules or components are subserved by 10 measurable tasks all implemented on the microcomputer (IBM-PC compatible) with reaction time measures as indices of the different facets of verbal efficiency. Statistical analyses of the large data sets for Phase 1 show the linear structural equation modelling fits the data reasonably well. In particular, the morphology task consistently explains between 32% to 44% of the variance in reading performance in the three grades. The findings lend themselves to specific approaches to habilitation in the different components or sub-components.This study was supported by a grant (No. 410-86-0048) from the Social Sciences and Humanities Research Council of Canada awarded to Che Kan Leong. Simon Lock and Jacky Lau were responsible for the microcompurter programming. Edward Danskin, Melvin Kelley, Donald Simmons, Louise Sellinger, Kristin Strauss and Tara Wiley carried out the experimentation with individual children in the schools. The cooperation of the principals, the teachers and the subjects was greatly appreciated. Requests for reprints should be addressed to Dr. C. K. Leong, Department for the Education of Exceptional children, University of Saskatchewan, Saskatoon, Canada, S7N OWO.