Measuring the unmeasurable: a country's non-R&D expenditure on product and service innovation

Knowledge about non-R&D innovation expenditure, such as patenting and licensing, design, trial production, tooling-up, manpower training, market research and investment in fixed assets, is extremely sparse and questions about the latter were very poorly answered in the recent Community Innovation Survey (CIS). Using information regarding the quality of replies, we reach a tentative national estimate of 1992 innovation expenditure for all manufacturing and service industries in the Netherlands. Expenditure on product-related R&D represents about one quarter of total product (and service) innovation expenditure. Roughly half of the latter consists of investment in fixed assets, the latter being more important in services than in manufacturing.     

Young people’s conversations about environmental and sustainability issues in social media

Young people’s conversations about environmental and sustainability issues in social media and their educational implications are under-researched. Understanding young people’s meaning-making in social media and the experiences they acquire could help teachers to stage pluralistic and participatory approaches to classroom discussions about the environment and sustainability. The aim of the article is to explore the characteristics of meaning-making in young people’s conversations about environmental and sustainability issue in social media, more precisely in an online community. The study takes a public pedagogy and citizenship-as-practice approach and uses Epistemological Move Analysis. The conversation are shown to be argumentative, sophisticated, elaborative and competitive and create an educational situation in which facts about the world and moral and political values and interests are confronted and argued. The findings raise questions about pluralistic and participatory approaches and the staging of classroom conversations in environmental and sustainability education.     

Does An Early Intervention Influence Behavioral Development Until Age 9 in Children Born Prematurely?

This study examined whether the Mother–Infant Transaction Program prevents behavioral problems among preterm children (birth weight < 2000 g) until age 9. The program was administered to 72 preterms, while 74 preterms and 75 full‐terms formed control groups (N = 221). Behavior was reported by parents (Child Behavior Checklist) and teachers (Teachers Report Form) and by all on selected Strengths and Difficulties Questionnaire (SDQ) questions. Long‐term behavioral development appeared to be qualitatively unaffected by the intervention. At ages 7 and 9, fewer attention problems and better adaptation to school were reported from parents and teachers of the intervention group compared to preterm controls. At age 9, teachers reported fewer difficulties in the intervention group and better academic performance. In these areas they were reported as being at the statistically same level as term controls.     

Changes among Israeli youth movements: a structural analysis based on Kahane’s code of informality

Multi-dimensional data analysis tools are applied to Reuven Kahane’s data on the informality of youth organizations, yielding a graphic portrayal of Kahane’s code of informality. This structure helps address questions of the whether the eight structural components exhaustively cover the field without redundancy. Further, the structure is used to examine changes in Israeli youth movements over two time periods (1925–1960 and 1960–1990). It is found that social aspects of the group have become more important, while ideology (especially socialist ideology) is less emphasized. Directions for continued research among youth movements since 1990 are explored.     

Intensity-dependent reductions in resting blood pressure following short-term isometric exercise training

To reduce resting blood pressure, a minimum isometric exercise training (IET) intensity has been suggested, but this is not known for short-term IET programmes. We therefore compared the effects of moderate- and low-intensity IET programmes on resting blood pressure. Forty normotensive participants (22.3 ± 3.4 years; 69.5 ± 15.5 kg; 170.2 ± 8.7 cm) were randomly assigned to groups of differing training intensities [20%EMG_peak (~23%MVC, maximum voluntary contraction, or 30%EMG_peak (~34%MVC)] or control group; 3 weeks of IET at 30%EMG_peak resulted in significant reductions in resting mean arterial pressure (e.g. ?3.9 ± 1.0 mmHg, P < 0.001), whereas 20%EMG_peak did not (?2.3 ± 2.9 mmHg; P > 0.05). Moreover, after pooling all female versus male participants, IET induced a 6.9-mmHg reduction in systolic blood pressure in female participants, but only a 1.5-mmHg reduction in systolic blood pressure in male participants, although the difference was not significant. An IET intensity between 20%EMG_peak and 30%EMG_peak is sufficient to elicit significant resting blood pressure reductions in a short-term training period (3 weeks). In addition, sexual dimorphism may exist in the magnitude of reductions, but further work is required to confirm this possibility, which could be important in understanding the mechanisms responsible.     

Does the Knowledge Spillover Theory of Entrepreneurship hold for regions?

The purpose of this paper is to test whether the Knowledge Spillover Theory of Entrepreneurship holds for regions. We do this by linking investments in knowledge by universities and regions to the amount of entrepreneurial activity associated with each university. Using binomial regressions we estimate how the number of young and high-tech firms located around universities depends on regional factors and the output of universities. The results clearly show that the number of firms located close to a university is positively influenced by the knowledge capacity of this region and the knowledge output of a university. Thus, there is considerable evidence suggesting that the Knowledge Spillover Theory of Entrepreneurship holds for regions as well as for industries.     

University spillovers and new firm location

This paper examines the impact of locational choice as a firm strategy to access knowledge spillovers from universities. Based on a large dataset of publicly listed, high-technology startup firms in Germany, we test the proposition that proximity to the university is shaped by different spillover mechanisms—research and human capital—and by different types of knowledge spillovers—natural sciences and social sciences. The results suggest that spillover mechanisms as well as spillover types are heterogeneous. In particular, the evidence suggests that new knowledge and technological-based firms have a high propensity to locate close to universities, presumably in order to access knowledge spillovers. However, the exact role that geographic proximity plays is shaped by the two factors examined in this paper—the particular knowledge context, and the specific type of spillover mechanism.     

Protein folding pathology in domestic animals

Fibrillar proteins form structural elements of cells and the extracellular matrix. Pathological lesions of fibrillar microanatomical structures, or secondary fibrillar changes in globular proteins are well known. A special group concerns histologically amorphous deposits, amyloid. The major characteristics of amyloid are: apple green birefringence after Congo red staining of histological sections, and non-branching 7-10 nm thick fibrils on electron microscopy revealing a high content of cross beta pleated sheets. About 25 different types of amyloid have been characterised. In animals,AA-amyloid is the most frequent type. Other types of amyloid in animals represent: AIAPP (in cats), AApoAⅠ, AApoAⅡ,localised AL-amyloid, amyloid in odontogenic or mammary tumors and amyloid in the brain. In old dogs Aβ and in sheep APrPsc-amyloid can be encountered. AA-amyloidosis is a systemic disorder with a precursor in blood, acute phase serum amyloid A (SAA). In chronic inflammatory processes AA-amyloid can be deposited. A rapid crystallization of SAA to shown to penetrate the enteric barrier. Amyloid fibrils can aggregate from various precursor proteins in vitro in particular at acidic pH and when proteolytic fragments are formed. Molecular chaperones influence this process. Tissue data point to amyloid fibrillogenesis in lysosomes and near cell surfaces. A comparison can be made of the fibrillogenesis in prion diseases and in enhanced AA-amyloidosis. In the reactive form, acute phase SAA is the supply of the precursor protein,whereas in tho prion diseases, cell membrane proteins form a structural source. Aβ-amyloid in brain tissue of aged dogs showing signs of dementia forms a canine counterpart of senile dementia of the Alzheimer type (ccSDAT) in man. Misfolded proteins remain potential food hazards. Developments concerning prevention of amyloidogenesis and therapy of amyloid deposits are shortly commented.     

A perspective on microfluidic biofuel cells

This review article presents how microfluidic technologies and biological materials are paired to assist in the development of low cost, green energy fuel cell systems. Miniaturized biological fuel cells, employing enzymes or microorganisms as biocatalysts in an environmentally benign configuration, can become an attractive candidate for small-scale power source applications such as biological sensors, implantable medical devices, and portable electronics. State-of-the-art biofuel cell technologies are reviewed with emphasis on microfabrication compatibility and microfluidic fuel cell designs. Integrated microfluidic biofuel cell prototypes are examined with comparisons of their performance achievements and fabrication methods. The technical challenges for further developments and the potential research opportunities for practical cell designs are discussed.