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41.
Silvia Izquierdo álvarez Eva Barrio Ollero Francisco Miguel Llinares Sanjuan Fabiola Lorente Martínez María Teresa Calvo Martín 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(1):159-166
Introduction:
Additional nucleotide substitutions in the 3′-untranslated region of prothrombin gene could explain some thrombotic events and also adverse pregnancy outcomes. We describe the first case of a homozygous 20209C>T mutation as the cause of deep vein thrombosis in a Spanish patient.Case and methods:
The 56-year-old male patient with a partial tear of the Achilles tendon developed calf (tibial) deep vein thrombosis after immobilization and was treated with an anticoagulant. To determine if the deep vein thrombosis was of genetic origin, a peripheral blood DNA sample was analysed for the presence of the three most frequent mutations associated with thrombotic events: factor V Leiden (1691G>A), prothrombin (20210G>A) and methylene tetrahydrofolate reductase (677C>T). The presence or absence of the normal allele of prothrombin could not be determined using the PTH-FV-MTHFR StripAssay (Vienna Lab).Results:
Comprehensive analysis showed that the patient had a variant interfering with the polymerase chain reaction product, we sequenced the entire prothrombin gene and found that the patient had a homozygous C>T mutation at position 20209; this interfered with the polymerase chain reaction product, which needs a C at this position to be able to bind to the wild-type probe present in the test strip.Conclusion:
The homozygous 20209C>T mutation and the presence of the mutation 677C>T in heterozygosity explained the patient’s deep vein thrombosis because the combination of mutations would increase the risk of thrombosis. Suitable genetic counselling should be provided to the patient and first-degree relatives as it important to detect prothrombin gene variants that could increase risk for thrombotic events. 相似文献42.
43.
Rocio Lorenzo-Alvarez Teodoro Rudolphi-Solero Miguel J. Ruiz-Gomez Francisco Sendra-Portero 《Anatomical sciences education》2020,13(5):602-617
Game-based learning can have a positive impact on medical education, and virtual worlds have great potential for supporting immersive online games. It is necessary to reinforce current medical students' knowledge about radiological anatomy and radiological signs. To meet this need, the objectives of this study were: to design a competition-based game in the virtual world, Second Life and to analyze the students' perceptions of Second Life and the game, as well as to analyze the medium-term retention of knowledge and the potential impact on the final grades. Ninety out of 197 (45.6%) third-year medical students voluntarily participated in an online game based on self-guided presentations and multiple-choice tests over six 6-day stages. Participants and non-participants were invited to perform an evaluation questionnaire about the experience and a post-exposure knowledge test. Participants rated the experience with mean scores equal to or higher than 8.1 on a 10-point scale, highlighting the professor (9.5 ± 1.1; mean ± SD) and the virtual environment (8.9 ± 1.1). Participants had better results in the post-exposure test than non-participants (59.0 ± 13.5 versus 45.3 ± 11.5; P < 0.001) and a lower percentage of answers left blank (6.7 ± 8.4 versus 13.1 ± 12.9; P = 0.014). Competitive game-based learning within Second Life is an effective and well-accepted means of teaching core radiological anatomy and radiological signs content to medical students. The higher medium-term outcomes obtained by participants may indicate effective learning with the game. Additionally, valuable positive perceptions about the game, the educational contents, and the potential benefit for their education were discovered among non-participants. 相似文献
44.
Thais Barbosa Monica Carolina Miranda Ruth F. Santos Orlando Francisco A. Bueno 《Reading and writing》2009,22(2):201-218
One of the most usual flaws that lead to literacy disability regards cognitive difficulties and alterations some children
present in the literacy process. Many studies have found alterations in phonological processing, more specifically in phonological
working memory (PWM) and phonological awareness (PA). Therefore, our aim was to identify alterations in skills of phonological
working memory, phonological awareness and language (semantic, syntactic and phonological aspects) of Brazilian children with
literacy disabilities (age 7–8). They were divided into two groups: (1) Group of Normal Literacy (NL); and (2) Group With
Literacy Disabilities (LD). The evaluation comprised tests that assessed general cognitive functions and the skills at stake.
The LD presented a poorer performance than the NL in the skills of PWM, PA and language aspects. The factor analysis showed
that these skills prevailed in differentiating the groups. Thus, children with literacy disabilities presented deficits in
phonological processing and language. These deficits seem to be a result of alterations of the phonological representations
and poor language skills that are prior to the literacy period. Consequently, we believe that the early identification of
these alterations can be very useful for the prevention of future literacy problems. 相似文献
45.
46.
Crime, which is an intriguing aspect of the human condition, has been the object of great concern amongst many modalities of knowledge. Even when dealing with the so-called "primal crime", dissolution is what always results. If people understand the primal crime of the mythical father as the necessary condition to cross from a horde to a clan state, eventually reaching a fraternal group state, then they should also understand that the social bond, which results from this action, brings in its kernel the scars of irreversible destruction. Freud's tyrannical father was murdered because he kept absolute enjoyment for himself, yet this crime did not set free the authors of the crime from their own enjoyment. The dynamics of the criminal act as a means of lust has been studied with the intent of articulating both perverse subjectivation and the pervert act, as well as considering the convict's standing in social relationships. Symbolization of reality and temporality are significantly altered by imprisonment, due mainly to lack of scopes and systematic conveying references which reflect reality. The study related to the temporal being of detainees is inferred as to better portray questionings on temporal subjection. The analysis of the discourse production lead to conclude: (1) When it is destined to penal institutions, the condemned lose pace with time (time halts); (2) Interns must render time objective (produce time). Rebellion and fights may be endeavors to create rhythm to register time, wherein, the desire to live time is, desperately, externalized; (3) Penal work is a time-reducing factor of imprisonment, therefore, time acquires objective and exchangeable value for the interns; and (4) Three worlds unfold and introduce themselves from the very moment when the imprisoned take place within a penal institution. The internal scope of the penal unit is propagated by the interns as being the inside world, exterior social context and relationships thereof are known as the outside world and the world of crime abides essentially different temporality notions. Within the inside world time halts, in the outside world time escapes and the crime world dimensions time is as time itself. 相似文献
47.
Juan J. Pulido David Sánchez-Oliva Francisco M. Leo Jorge Sánchez-Cano Tomás García-Calvo 《Measurement in physical education and exercise science》2018,22(1):25-37
Purpose: The objectives were to develop and validate the Coaches’ Interpersonal Style Questionnaire. The Coaches’ Interpersonal Style Questionnaire analyzes the interpersonal style adopted by coaches when implementing their strategy of supporting or thwarting athletes’ basic psychological needs. Method: In Study 1, an exploratory factor analysis was performed with 265 Spanish male athletes, between 11- and 17-years-old, to confirm the internal structure of the questionnaire. Study 2 was conducted with 430 athletes, also between 11- and 17-years-old. Both confirmatory factor analysis and exploratory structural equation modeling were used to test a set of alternative models to find the best measurement model. Results: The hierarchical exploratory structural equation modeling model showed the best fit to the data and acceptable standardized factor loadings. Concurrent validity was revealed through correlational analysis of the basic psychological need satisfaction and frustration. Conclusion: This study provides a multi-dimensional questionnaire to assess coaches’ interpersonal style perceived by athletes. 相似文献
48.
Bastian Carter-Thuillier Víctor López-Pastor Francisco Gallardo-Fuentes 《Infancia y Aprendizaje》2018,41(3):491-535
This study analyses the integration of Mapuche-Huilliche students who participate in a school sport programme based on the teaching for understanding model in a situation of social risk. In this context, 41 students (aged nine to 12) participate, 24 of whom are from the aforementioned ethnic group. To collect data, participant observation was conducted for eight months and group and individual interviews were held. The results show that the Mapuche-Huilliche students recognize themselves as members of the same collective when participating in games associated with their ethnic group. Their main motives for participating in school sport are the teaching approach and the acquisition of social capital. Cooperative learning activities are shown to foster positive interactions with non-Mapuche students. 相似文献
49.
Saleh A. Al-Abood Simon J. Bennett Francisco Moreno Hernandez Derek Ashford Keith Davids 《Journal of sports sciences》2013,31(3):271-278
We assessed the effects on basketball free throw performance of two types of verbal directions with an external attentional focus. Novices ( n = 16) were pre-tested on free throw performance and assigned to two groups of similar ability ( n = 8 in each). Both groups received verbal instructions with an external focus on either movement dynamics (movement form) or movement effects (e.g. ball trajectory relative to basket). The participants also observed a skilled model performing the task on either a small or large screen monitor, to ascertain the effects of visual presentation mode on task performance. After observation of six videotaped trials, all participants were given a post-test. Visual search patterns were monitored during observation and cross-referenced with performance on the pre- and post-test. Group effects were noted for verbal instructions and image size on visual search strategies and free throw performance. The 'movement effects' group saw a significant improvement in outcome scores between the pre-test and post-test. These results supported evidence that this group spent more viewing time on information outside the body than the 'movement dynamics' group. Image size affected both groups equally with more fixations of shorter duration when viewing the small screen. The results support the benefits of instructions when observing a model with an external focus on movement effects, not dynamics. 相似文献
50.
Amador García-Ramos Paola Barboza-González David Ulloa-Díaz Angela Rodriguez-Perea Darío Martinez-Garcia Francisco Guede-Rojas 《Journal of sports sciences》2013,31(19):2205-2212
ABSTRACTThis study examined the reliability and validity of three methods of estimating the one-repetition maximum (1RM) during the free-weight prone bench pull exercise. Twenty-six men (22 rowers and four weightlifters) performed an incremental loading test until reaching their 1RM, followed by a set of repetitions-to-failure. Eighteen participants were re-tested to conduct the reliability analysis. The 1RM was estimated through the lifts-to-failure equations proposed by Lombardi and O’Connor, general load-velocity (L-V) relationships proposed by Sánchez-Medina and Loturco and the individual L-V relationships modelled using four (multiple-point method) or only two loads (two-point method). The direct method provided the highest reliability (coefficient of variation [CV] = 2.45% and intraclass correlation coefficient [ICC] = 0.97), followed by the Lombardi’s equation (CV = 3.44% and ICC = 0.94), and no meaningful differences were observed between the remaining methods (CV range = 4.95–6.89% and ICC range = 0.81–0.91). The lifts-to-failure equations overestimated the 1RM (3.43–4.08%), the general L-V relationship proposed by Sánchez-Medina underestimated the 1RM (?3.77%), and no significant differences were observed for the remaining prediction methods (?0.40–0.86%). The individual L-V relationship could be recommended as the most accurate method for predicting the 1RM during the free-weight prone bench pull exercise. 相似文献