Living Matter in Crash Test： How Biomolecules Respond to Mechanical Forces

<正>The Group on Protein Mechanics and Evolution at the CAS-MPG Partner Institute for Computational Biology,Shanghai,was established in January 2007 and headed by Dr.Frauke Gr?ter.The Klaus Tschira Lab has continued the eff orts of this former Independent Junior Research Group,since Dr.Gr?ter took up a position at the Heidelberg Institute of Theoretical Studies(HITS)in Heidelberg,Germany,in     

Interlibrary loan and document delivery in North American health sciences libraries during the early months of the COVID-19 pandemic

Objective:The study purpose was to understand how early months of the COVID-19 pandemic altered interlibrary loan (ILL) and document delivery (DD) in North American health science libraries (HSLs), specifically the decision-making and workflow adjustments associated with accessing their own collections and obtaining content not available via ILL.Methods:Researchers distributed an online 26-question survey through 24 health science library email lists from January 6-February 7, 2021. Respondents reported their library''s ILL and DD activities from March-August 2020, including ILL/DD usage and policies, collection access, decision-making, and workflow adjustments. In addition to calculating frequencies, cross-tabulation and statistical tests were performed to test a priori potential associations. Two researchers independently and thematically analyzed responses to the 2 open-ended questions and reached consensus on themes.Results:Hospital libraries represented 52% (n=226/431) of respondents, along with 42% academic (n=179) and 6% (n=26) multi-type or other special. Only 1% (n=5) closed completely with no remote services, but many, 45% (n=194), ceased ILL of print materials. More than half (n=246/423; 58%) agreed that ILL requests likely to be filled from print remained unfilled more than is typical. Open-ended questions yielded 5 themes on ILL/DD staffing, setup, and systems; 6 on impacts for libraries and library users.Conclusion:Lack of communication regarding collection availability and staffing resulted in delayed or unfilled requests. Hospital and academic libraries made similar decisions about continuing services but reported different experiences in areas such as purchasing digital content. Hybrid ILL/DD workflows may continue for managing these services.     

The development of affective subscales to reflect variation in students' experiences of studying mathematics in higher education

The focus of this paper is on the isolation and modelling of a set of affective sources of variation in student learning that seem specific to the discipline of mathematics. Such affective sources contribute to developing a more comprehensive discipline-specific model of student learning that can provide information about individual students, and the context of their learning engagement, in terms that are sufficiently specific for counselling and other forms of teacher-based interventions. The first part of the paper describes the development of conceptually discrete subscales to represent these sources of variation, and their associated psychometric properties. These subscales constitute the Experiences of Studying Mathematics Inventory (ESMI). The second part describes a field trialling of the ESMI subscales to test their sensitivity to influences and learning outcomes within a particular context of first year mathematics studies.     

A novel μ-fluidic whole blood coagulation assay based on Rayleigh surface-acoustic waves as a point-of-care method to detect anticoagulants

A universal coagulation test that reliably detects prolonged coagulation time in patients, irrespective of the anticoagulant administered, has not been available to date. An easily miniaturised, novel μ-fluidic universal coagulation test employing surface acoustic waves (SAW) is presented here. SAW was employed to instantly mix and recalcify 6 μl citrated whole blood and image correlation analysis was used to quantify clot formation kinetics. The detection of clinically relevant anticoagulant dosing with old anticoagulants (unfractionated heparin, argatroban) and new anticoagulants (dabigatran, rivaroxaban) has been tested and compared to standard plasma coagulation assays. The applicability of this novel method has been confirmed in a small patient population. Coagulation was dose-proportionally prolonged with heparin, argatroban, dabigatran, and rivaroxaban, comparable to standard tests. Aspirin and clopidogrel did not interfere with the SAW-induced clotting time (SAW-CT), whereas the strong GPIIb/IIIa-inhibitor abciximab did interfere. Preliminary clinical data prove the suitability of the SAW-CT in patients being treated with warfarin, rivaroxaban, or dabigatran. The system principally allows assessment of whole blood coagulation in humans in a point-of-care setting. This method could be used in stroke units, emergency vehicles, general and intensive care wards, as well as for laboratory and home testing of coagulation.     

THE GROWTH AND RESOURCES OF TRAINING SCHOOLS

Teachers are thought to be the backbone of any high school. Data indicating how students perceive their teachers was gathered from a questionnaire completed by 355 recent Yeshiva high-school graduates. Results show that Yeshiva High School teachers are thought of as open minded and tolerant (51.9%), caring (73.2%), and interested in developing the teacher/student relationship (77.2%). The 66% of Yeshiva students who viewed teachers as positive role models stood in sharp contrast to the 2.4% of the general high-school population reported in the literature who viewed teachers as positive role models.     

A gender comparison of contextualised study behaviour in higher education

The present study examines the manifestation of structural differences in the manner in which men and women students perceive and engage the content and context of learning. These differences are explored, and shown to be consistent, within a hierarchy of progressively more complex conceptual models of student learning. Conclusions are that structural gender variation differences emerge in terms of deep/strategic rather than surface, forms of learning behaviour: men students distinctively manifest and qualify deep/strategic learning behaviour in terms of operation and comprehension learning styles, while women students integrate these styles in a manifestation of style versatility that is clearly organised and not achievement motivated. An apparently separate female trait is distinguishable in terms of comprehension learning style and achievement motivation. It is argued that gender differences constitute a potentially important and neglected source of variation in student learning which, when detected in context, can and should be explicitly managed by academic practitioners.