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941.
942.
Liu Ai-jun Furusato Bungo Ravindranath Lakshmi Chen Yong-mei Srikantan Vasanta Mcleod David G. Petrovics Gyorgy Srivastava Shiv 《Journal of Zhejiang University. Science. B》2007,8(12):853-859
Objective To investigate molecular alterations associating with prostate carcinoma progression and potentially provide information toward
more accurate prognosis/diagnosis.
Methods A set of laser captured microdissected (LCM) specimens from 300 prostate cancer (PCa) patients undergoing radical prostatectomy
(RP) were defined. Ten patients representing “aggressive” PCa, and 10 representing “non-aggressive” PCa were selected based
on prostate-specific antigen (PSA) recurrence, Gleason score, pathological stage and tumor cell differentiation, with matched
patient age and race between the two groups. Normal and neoplastic prostate epithelial cells were collected with LCM from
frozen tissue slides obtained from the RP specimens. The expressions of a panel of genes, including NPY, PTEN, AR, AMACR, DD3, and GSTP1, were measured by quantitative real-time RT-PCR (TaqMan), and correlation was analyzed with clinicopathological features.
Results The expressions of AMACR and DD3 were consistently up-regulated in cancer cells compared to benign prostate epithelial cells in all PCa patients, whereas
GSTP1 expression was down regulated in each patient. NPY, PTEN and AR exhibited a striking difference in their expression patterns between aggressive and non-aggressive PCas (P=0.0203, 0.0284, and 0.0378, respectively, Wilcoxon rank sum test). The lower expression of NPY showed association with “aggressive” PCas based on a larger PCa patient cohort analysis (P=0.0037, univariate generalized linear model (GLM) analysis).
Conclusion Despite widely noted heterogeneous nature of PCa, gene expression alterations of AMACR, DD3, and GSTP1 in LCM-derived PCa epithelial cells suggest for common underlying mechanisms in the initiation of PCa. Lower NPY expression level is significantly associated with more aggressive clinical behavior of PCa; PTEN and AR may have potential in defining PCa with aggressive clinical behavior. Studies along these lines have potential to define
PCa-associated gene expression alterations and likely co-regulation of genes/pathways critical in the biology of PCa onset/progression.
Project supported by the Center for Prostate Disease Research, and the Henry M. Jackson Foundation for the Advancement of
Military Medicine, Rockville, MD, USA 相似文献
943.
Several reasons for the modest relation between interest congruence and occupational outcomes are discussed, but focus is placed on possible moderators of this relation. Specifically individual differences, environmental differences and time are proposed as potential moderators. Overall, it is important to investigate theoretically driven moderators of the congruence-outcome relation to further our knowledge of this area. 相似文献
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945.
Paul G. Chigwidden 《British Journal of Religious Education》2020,42(2):129-140
ABSTRACTFor some time now, the idea of secularism has been the subject of renewed scrutiny. Statistical portraits, representing a simple, if relentless, narrative have been increasingly disparaged by scholars as unhelpful. Statistical secularism, as we may call it, tells a story of decline and little else. It is incapable of telling the real story which is one in which religious experience becomes hyper-fragmented. The memoirs and reminiscences of those English intellectuals who came to maturity in the interwar period have a contribution to make to this discussion. These pieces of life-writing reveal both the march of secularism in action but also the emergence of new religious experiences. At the heart of these radical changes was a widespread dissatisfaction with the way in which they were taught their religious faith. Where the experts of their day cautioned against teaching students doctrine, students like Evelyn Waugh, W. H. Auden and John Betjeman were particularly critical of that very concession. Thus, we get the chance to tease out an attitudinal pattern towards the religious education of the period and its contribution to the growing experience of secularism. 相似文献
946.
Lang HG Biser E Mousley K Orlando R Porter J 《Journal of deaf studies and deaf education》2004,9(2):189-201
Seventy-three deaf college students completed a survey examining perceptions about tutoring outcomes and emphases, characteristics of tutors, and responsibilities associated with learning through tutoring. The comparisons revealed that while baccalaureate and sub-baccalaureate students have many similar perceptions about tutoring, there are also some striking differences. In particular, as compared to the sub-baccalaureate students, baccalaureate students have a stronger preference for focusing on course content and for working with tutors who actively involve them during the tutoring sessions. In addition, baccalaureate students prefer to decide the focus of the tutoring themselves while sub-baccalaureate students tend to leave the decision to the tutor. The results of the analyses with three scales measuring perceptions of tutoring dimensions are summarized and recommendations for the selection and preparation of tutors, as well as for future research, are provided. 相似文献
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950.
Dianne J. Hall Casey G. Cegielski James N. Wade 《Decision Sciences Journal of Innovative Education》2006,4(2):237-257
The research described in this article reports the results of a study designed to evaluate the relationship among object‐oriented (OO) computer programming task performance and a student's (1) theoretical value belief, (2) cognitive ability, and (3) personality. The results of this study do not support the assertion that cognitive ability is a main determinant of performance. Rather, the findings suggest that characteristics of an individual nature have more effect on a student's performance. This supports our belief advanced herein that theoretical value belief and personality are significant predictors of computer programming performance in OO environments. From the findings of this study, we assert that academicians who must teach OO computer programming consider these factors when developing course materials or student assistance programs. 相似文献