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981.
A. Bhise P. V. Krishnan R. Aggarwal M. Gaiha J. Bhattacharjee 《Indian journal of clinical biochemistry : IJCB》2005,20(2):4-9
The present study comprised 100 patients of essential hypertension who were screened for fasting hyperinsulinemia, which was
detected in 77% cases. Twenty such hyperinsulinemic cases were subjected to 4 weeks of dietary control phase followed by 6
weeks of omega-3 fatty acids substitution [either 0.6 g/d (group 1) or 1.2 g/d (group 2)]. The mean basal fasting plasma insulin
levels were significantly higher (p<0.001) in patients of hypertension when compared to normal controls (126.51±80.36 and
19.35±12.61 μU/ml respectively). At the end of 4 weeks of diet control only, no significant change was observed in any parameter.
After substitution of omega-3 fatty acid, a significant reduction of fasting plasma insulin levels in both group 1 (29%) and
group 2 (22.8%) was observed (p<0.001). Significant reduction of systolic and diastolic blood pressure (16.4% and 25% respectively),
serum cholesterol, triglycerides and low density lipoprotein was also noted in both groups (p<0.001), while high density lipoprotein
increased by ∼8 mg% in both groups. Thus omega-3 fatty acid substituion in low dose along-with curtailment of dietary omega-6
fatty acid may be used as an adjunctive measure in the management of essential hypertension. 相似文献
982.
Gamma Glutamyl Transferase (γ-GT) is a microsomal enzyme. Its activity in serum is assayed in alcoholics with liver abscess
and alcoholics without liver abscess after screening by ultrasonography. The enzyme activity in serum is increased by 334%
in the patients with liver abscess compared to normal control subjects (p<0.0001), and 172% when compared to patients with
chronic alcoholism without liver abscess (p<0.0001). The enzyme activity was increased by 59.3% in the serum of patients without
liver abscess compared to the normal control subjects (p<0.001). Measurement of γ-GT in serum appears to be a sensitive index
in the diagnosis of alcoholics with liver abscess. 相似文献
983.
R. Nalini C. R. Wilma Delphine Silvia Purnima M. Makhija Sheila Uthappa 《Indian journal of clinical biochemistry : IJCB》2005,20(1):165-168
Prognostic factors influence the modality and course of therapy in breast cancer. These include both histopathological and
biochemical variables. This study was aimed to find out if any correlation exists between the biochemical tumor marker-serum
CA 15.3, and the lymph node staging of Nottingham’s Prognostic Index (NPI). It was observed that serum CA 15.3 showed a statistically
significant correlation with lymph node staging of NPI. Therefore it is concluded that CA 15.3 can be utilized as a useful
prognostic marker, particularly in cases where histopathological variables such as tumor size and grade have been altered
by pre-operative chemotherapy. 相似文献
984.
The increasing number of interactions between Taiwan and the Mainland may bring in both opportunities and competitions among the companies in the region. Companies are forced to continuously change and develop to advance and to sustain in the competitive environment. It also holds true for the companies in the even more competitive high-tech industries. It is therefore of a value to study what challenges the high-tech firms are facing, how these challenges impact on their performance and how these firms are dealing with issues. Among the multiple challenges, supply chain operation has been a critical issue concerning the high-tech manufacturers.The purpose of this study is to investigate the relationships between the various supply chain operation determinants (relationships with business partners, internal operation) and the impacts of relationships with supply chain partners on the internal operation and the collective efficacy relating to the scheduling issues in high-tech manufacturing firms in Taiwan. A research framework linking internal operation and relationships with supply chain partners (supplier and customer) and individuals (perceived collective efficacy) is applied. 相似文献
985.
Gergely Simon Caroline Busch Marco A. B. Andrade Julien Reboud Jonathan M. Cooper Marc P. Y. Desmulliez Mathis O. Riehle Anne L. Bernassau 《Biomicrofluidics》2021,15(1)
Separation and sorting of biological entities (viruses, bacteria, and cells) is a critical step in any microfluidic lab-on-a-chip device. Acoustofluidics platforms have demonstrated their ability to use physical characteristics of cells to perform label-free separation. Bandpass-type sorting methods of medium-sized entities from a mixture have been presented using acoustic techniques; however, they require multiple transducers, lack support for various target populations, can be sensitive to flow variations, or have not been verified for continuous flow sorting of biological cells. To our knowledge, this paper presents the first acoustic bandpass method that overcomes all these limitations and presents an inherently reconfigurable technique with a single transducer pair for stable continuous flow sorting of blood cells. The sorting method is first demonstrated for polystyrene particles of sizes 6, 10, and 14.5 μm in diameter with measured purity and efficiency coefficients above 75 ± 6% and 85 ± 9%, respectively. The sorting strategy was further validated in the separation of red blood cells from white blood cells and 1 μm polystyrene particles with 78 ± 8% efficiency and 74 ± 6% purity, respectively, at a flow rate of at least 1 μl/min, enabling to process finger prick blood samples within minutes. 相似文献
986.
Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang 《国家科学评论(英文版)》2020,7(6):952
Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway. 相似文献
987.
Size-dependent trajectories of DNA macromolecules due to insulative dielectrophoresis in submicrometer-deep fluidic channels 总被引:1,自引:0,他引:1
Gea O. F. Parikesit Anton P. Markesteijn Oana M. Piciu Andre Bossche Jerry Westerweel Ian T. Young Yuval Garini 《Biomicrofluidics》2008,2(2)
In this paper, we demonstrate for the first time that insulative dielectrophoresis can induce size-dependent trajectories of DNA macromolecules. We experimentally use λ (48.5 kbp) and T4GT7 (165.6 kbp) DNA molecules flowing continuously around a sharp corner inside fluidic channels with a depth of 0.4 μm. Numerical simulation of the electrokinetic force distribution inside the channels is in qualitative agreement with our experimentally observed trajectories. We discuss a possible physical mechanism for the DNA polarization and dielectrophoresis inside confining channels, based on the observed dielectrophoresis responses due to different DNA sizes and various electric fields applied between the inlet and the outlet. The proposed physical mechanism indicates that further extensive investigations, both theoretically and experimentally, would be very useful to better elucidate the forces involved at DNA dielectrophoresis. When applied for size-based sorting of DNA molecules, our sorting method offers two major advantages compared to earlier attempts with insulative dielectrophoresis: Its continuous operation allows for high-throughput analysis, and it only requires electric field strengths as low as ∼10 V∕cm. 相似文献
988.
西藏那曲地区气候变化与牧业生产的关系 总被引:4,自引:1,他引:4
根据那曲地区气象观测资料以及不同时段牧业生产、经济效益等方面的社会统计资料,分析了近年来该地区气候变化规律、牲畜存栏、牲畜饲养、经济效益收入等状况。在此基础上,讨论了当地气候变化与牧业生产之间的关系。结果表明:那曲地区的气候变化呈现气温增高,降水量、相对湿度、低云量增加,蒸发量、总云量、日照时数减少的趋势;那曲地区牲畜总头数、不同牲畜数量、牦牛出栏数(率)、羊出栏数(率)、仔畜成活数量呈增加趋势,牲畜死亡数呈减少趋势;总收入与牧业收入均有急剧的增长。那曲地区牧业生产与气象要素(最高气温除外)存在着密切联系,即最低气温、降水量、相对湿度、低云量与各牧业要素呈正相关,蒸发量、总云量、日照时数与牧业要素呈负相关。总体来看,气象要素的变化趋势有利于牧业生产,根据气象条件建立的拟合方程基本可以拟合出牧业要素的变化。 相似文献
989.
Benedicta D’Souza Vivian D’Souza S. Sowmya G. Seema C. N. Hemalatha M. Anu G. Sajana 《Indian journal of clinical biochemistry : IJCB》2008,23(3):218-222
The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs)
with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid
and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found
in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly
in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased
in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels
were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric
acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and
increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes. 相似文献
990.
Bret G. Range Susan Scherz Carleton R. Holt Suzanne Young 《Educational Assessment, Evaluation and Accountability》2011,23(3):243-265
The intent of this study was to assess the perceptions and actions of Wyoming principals concerning their role in supervising
and evaluating teachers. A survey was sent to all 286 principals in the state of Wyoming, of which, 143 returned surveys,
a response rate of 50%. Findings suggested that principals utilized supervisory behaviors more often than evaluative behaviors.
Elementary principals perceived their evaluative practices as significantly more prevalent than secondary principals. Furthermore,
principals indicated that their greatest frustrations in supervising teachers were time, the evaluation instrument, and teachers’
unwillingness to change. Additionally, findings suggested that Wyoming principals utilized classroom walkthroughs because
they provided a snapshot of teaching and provided a medium for providing feedback. In regards to developmental supervision,
principals indicated that novice teachers received much more supervision than veteran teachers. However, their reported use
of differentiated supervision only applied to teacher autonomy concerning professional development goals. Principals reported
that teachers had little input concerning the methods by which they were supervised. Finally, a majority of the Wyoming principals
felt that improvement plans were effective at changing mediocre teaching behaviors, but 40% were speculative that such plans
truly remediated poor teachers. 相似文献