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Manorama Swain Preetam Nath Prasant Kumar Parida Jimmy Narayan Pradeep Kumar Padhi Girish Kumar Pati Ayaskanta Singh Bijay Misra Debasis Misra Sanjib Kumar Kar Manas Kumar Panigrahi Chudamani Meher Omprakash Agrawal Niranjan Rout Kaumudee Pattnaik Pallavi Bhuyan Pramila Kumari Mishra Shivaram Prasad Singh 《Indian journal of clinical biochemistry : IJCB》2017,32(3):306-314
Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in nonalcoholic fatty liver disease (NAFLD). Aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD. Single center observational study was conducted in a gastroenterology clinic at Cuttack in coastal Odisha. Subjects were consecutive patients presenting with functional bowel disease and undergoing abdominal sonography. All participants were evaluated for the presence of metabolic syndrome (MS), insulin resistance, liver function test and lipid profile. Various parameters were compared between NAFLD subjects and controls. 53.5 % of NAFLD had normal serum transaminases, whereas 20.8 % of healthy controls had transaminitis. NAFLD patients had significantly higher BMI, fasting plasma glucose, serum transaminases, serum triglycerides, serum insulin and homeostatic model assessment (HOMA) IR than controls. NAFLD patients who had transaminitis had significantly higher incidence of MS and higher mean HOMA IR than those without. There was no significant difference in histopathological features between NAFLD with and without transaminitis. To conclude, over half of NAFLD subjects do not have transaminitis while transaminitis is present in a fifth of healthy people without fatty liver. Hence serum transaminase should not be used as screening test for NAFLD. NAFLD patients with transaminitis had a higher incidence of MS and insulin resistance than those without. However, there was no significant difference in histopathological features between these two groups. 相似文献
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Chetna Bhatt Zarangis Misra Neelam Goyel 《Indian journal of clinical biochemistry : IJCB》2008,23(1):10-16
Mental Retardation is a condition where complex interactions of intrinsic and extrinsic factors hamper mental and sometimes
physical growth of the child during developmental period. This study was carried out to detect cause of Mental Retardation
in 2000 cases of developmental delay by a multidisciplinary team comprising of a Pediatrician, Cytogeneticist, Biochemist,
Psychologist and Speech and Occupational therapists. The causes for developmental delay are broadly divided into Genetic,
Environmental and Idiopathic (no specific cause found) factors. The complete diagnosis was possible in 1192(60%) cases. Genetic
factors were found in 477(23.8%) cases and environmental factors covered 692(34.6%) cases as a cause of retardation. The most
common genetic cause is chromosomal abnormalities which were found in 355 (17.75%) cases. Another major group comprising of
122 (6.1%) cases was that of the disorders which follow Mendelian inheritance. Autosomal recessive conditions, which covers
majority of metabolic disorders, are detected in 48(2.4%) cases. During this screening the most common inherited metabolic
condition detected is Mucopolysaccharidosis, a Lysosomal Storage Disorder followed by Amino acid abnormalities like Phenylketonuria,
Alkaptonuria and Tyrosinuria. 相似文献
14.
Advocates for educational reform frequently call for policies to increase competition between schools because it is argued that market forces naturally lead to greater efficiencies, including improved student learning, when schools face competition. Researchers examining this issue are confronted with difficulties in defining reasonable measures of competition within local educational markets. We approach the problem through the application of Geographical Information System (GIS) tools to the development of a school competition index (SCI) for the state of Mississippi. The SCI captures the degree of competition each public school in the state faces from peer private schools spatially located within their local market area. We find that higher degrees of competition from private schools significantly increase public primary and high school efficiency, as measured by the proficiency rates on high-stakes examinations. It is anticipated that the current results will inform policymakers regarding the viability of competition-based reforms. 相似文献
15.
Rashmi Raghuvanshi Aiki Kaul Pushpa Bhakuni Aparna Mishra M. K. Misra 《Indian journal of clinical biochemistry : IJCB》2007,22(2):90-92
In the present communication, we report remarkably elevated levels of xanthine oxidase activity in the blood of the patients
with myocardial infarction when compared to age and sex matched healthy persons. Highly significant increase of malondialdehyde,
serving as an index of lipid peroxidation and thus free radical mediated damage, has also been found in the patients. We propose
the measurement of the blood levels of xanthine oxidase, a very simple, reliable and less time consuming method as an indicator
of myocardial infarction. 相似文献
16.
Richard L. Peterson Mark L. Berenson Ram B. Misra David J. Radosevich 《Decision Sciences Journal of Innovative Education》2008,6(2):375-402
Student faculty ratings are used at most institutions of higher learning for three important reasons. First, the ratings provide direct feedback to the faculty, and this enables faculty to adjust their teaching styles. Second, the ratings provide the administration with information intended to assist in guiding and mentoring faculty toward more effective pedagogical performance in the classroom. Third, the ratings also provide the administration with information to be used in the reappointment, tenure, and promotion processes, as well as for assignment of salary range adjustments and teaching awards. To be of real value, however, all of this is predicated on the use of a valid and reliable faculty‐rating instrument along with a system designed to provide both the faculty and the administration with norming reports that allow for appropriate comparisons of ratings. This article reports such a study conducted within a large department of a business school and recommends that the process used be adapted by other business school departments and other academic units across the university and at other universities to ensure a more universally appropriate usage of students’ ratings. 相似文献
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T. K. Saha Arabinda Mohan Bhattarai H. S. Batra Mithu Banerjee Pratibha Misra Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2015,30(3):271-274
Increase in urine albumin excretion rate (AER) precede a fall in glomerular
filtration rate in patients developing diabetic chronic kidney disease (CKD). Our
results have shown that 7 (50 %) of diabetic and hypertensive individuals with
decreased GFR do not have increased AER. In this cross-sectional study, we measured
AER of 75 patients with type 2 diabetes and hypertension by immunoturbidimetric
method. We correlated the results with eGFR values obtained by Cockcroft–Gault and
MDRD method. The method used was not a compensated method. We measured serum
creatinine by modified Jaffe’s kinetic method in autoanalyzer XL-600. Analysis of
data showed positive correlation between eGFR and microalbuminuria by both the
methods with eGFR <60 mL/min/1.73 m2. Pearson’s
correlation co-efficient (r) was 0.9 (p = 0.0001)
by Cockcroft–Gault formula and 0.69 (p = 0.0063)
by MDRD formula. Our results concluded that there was positive correlation between
AER and eGFR <60 mL/min/1.73 m2. We have recognized
that these two parameters provide a complimentary benefit in management of cases
with CKD. 相似文献
18.
M. Chandra D. R. Maurya S. Kumar H. Basara A. Ghatak B. L. Tekwani G. Kaur M. K. Misra 《Indian journal of clinical biochemistry : IJCB》2003,18(2):150-153
Despite enormous research in the field of hypertension, its pathophysiology still remains largely unresolved and appears to
be multifactorial. In the present communication, we have analyzed the status of nitric oxide (NO) in the patients with essential
hypertension and age matched controls. We have found that the levels of NO are lowered in essential hypertension. The normalization
of blood pressure by administration of antihypertensive therapy causes rise in the NO level indicating that perturbed NO status
in essential hypertension is reversible. Addition of antioxidant to the antihypertensive drugs causes a further, though non
significant, rise in the levels of NO, suggesting that antioxidants may be combined with antihypertensive drugs as adjunct
in the management of essential hypertension. 相似文献
19.
Pratima Tripathi M. K. Misra Shivani Pandey 《Indian journal of clinical biochemistry : IJCB》2012,27(3):296-299
Oxidative stress conditions associated with atherosclerosis leads to oxidative modification of low-density lipoprotein (LDL). The body’s capabilities to inhibit LDL oxidation and to remove or neutralize the atherogenic oxidized LDL (ox-LDL) are limited. When the LDL cholesterol level increases in the blood, it leads to dangerous consequences like atherosclerosis, leading to myocardial infarction. The major effect of an antioxidant in the LDL environment is to prevent the formation of ox-LDL (during atherogenesis. Strategies to reduce LDL oxidation and prevent atherogenesis can involve the enrichment of arterial cells with potent antioxidants that can prevent oxidative damage to the arterial wall. The objective of this study is to evaluate the effect of l-arginine on serum lipid and cholesterol levels in the patients of acute myocardial infarction (AMI). The study consisted of 70 AMI patients and 60 healthy individuals (serving as control) age 55–65 years. Serum levels of total cholesterol, high density lipoprotein (HDL), LDL and Triglycerides were determined on day 1 and day 15 of l-arginine administration (oral dose 3 g/day). The total cholesterol/HDL and the LDL/HDL ratio were calculated and compared. As per the observations, l-arginine administration was found to improve the lipid profile of the subjects. Hence it could be used as an adjuvant therapy for AMI and as a preventive measure for the onset of the disease in the healthy elderly also. 相似文献
20.
Neeldhara Misra 《Resonance》2008,13(7):662-679
In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. We may suggest strategies for dealing
with them, or invite responses, or both. “Classroom” is equally a forum for raising broader issues and sharing personal experiences
and viewpoints on matters related to teaching and learning science. 相似文献