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91.
K. K. Mishra H. P. Pandey R. H. Singh 《Indian journal of clinical biochemistry : IJCB》1993,8(1):26-28
Present study, involved two groups of chronic stress disorders, e.g. bronchial asthma and rheumatoid arthritis. Clinical investigations were launched on the blood samples of human subjects in which the levels of plasma cortisol, blood glucose, total plasma protein and serum cholesterol were assayed in diseased and normal control subjects. Observations in-vitro exhibited a notable change in the levels of all the biochemical parameters in patients of chronic disorders with respect to those of normal controls. The biochemical changes in asthmatics were comparatively more pronounced than those of rheumatoid arthritis patients. It reveals that bronchial asthma is an acute and early onset disorder because with chronicity of stressful events, there is a decline in stress response since hypothalamo-pituitary-adrenal (HPA) axis is not so competent to undergo major remodelling of its circuitry necessary for homeostatic maintanence. 相似文献
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Acoustic radiation forces have been used to manipulate cells and bacteria in a number of recent microfluidic
applications. The net force on a cell has been subject to careful investigation over a number of decades. We
demonstrate that the radiation forces also act to deform
cells. An
ultrasonic standing
wave field is created in a
0.1 mm glass capillary at a frequency of 7.9 MHz. Using osmotically swollen red-blood cells, we show observable
deformations up to an aspect
ratio of 1.35, comparable to deformations created by optical tweezing. In contrast to optical technologies,
ultrasonic devices are
potentially capable of deforming thousands of cells simultaneously. We create a finite element model that includes both the acoustic
environment of the cell, and a model of the cell
membrane subject to forces resulting from the non-linear aspects of the acoustic
field. The model is found to
give reasonable agreement with the experimental results, and shows that the deformation is the result of variation in
an acoustic force that is directed outwards at all points on the cell membrane. We foresee applications in
diagnostic devices, and in the possibility of mechanically stimulating cells to promote differentiation and
physiological effects. 相似文献
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Bibhas Roy Gautam Chattopadhyay Debasish Mishra Tamal Das Suman Chakraborty Tapas K. Maiti 《Biomicrofluidics》2014,8(3)
An on-chip lectin microarray based glycomic approach is employed to identify glyco markers for different gastritis and gastric cancer. Changes in protein glycosylation have impact on biological function and carcinogenesis. These altered glycosylation patterns in serum proteins and membrane proteins of tumor cells can be unique markers of cancer progression and hence have been exploited to diagnose various stages of cancer through lectin microarray technology. In the present work, we aimed to study the alteration of glycan structure itself in different stages of gastritis and gastric cancer thoroughly. In order to perform the study from both serum and tissue glycoproteins in an efficient and high-throughput manner, we indigenously developed and employed lectin microarray integrated on a microfluidic lab-on-a-chip platform. We analyzed serum and gastric biopsy samples from 8 normal, 15 chronic Type-B gastritis, 10 chronic Type-C gastritis, and 6 gastric adenocarcinoma patients and found that the glycoprofile obtained from tissue samples was more distinctive than that of the sera samples. We were able to establish signature glycoprofile for the three disease groups, that were absent in healthy normal individuals. In addition, our findings elucidated certain novel signature glycan expression in chronic gastritis and gastric cancer. In silico analysis showed that glycoprofile of chronic gastritis and gastric adenocarcinoma formed close clusters, confirming the previously hypothesized linkage between them. This signature can be explored further as gastric cancer marker to develop novel analytical tools and obtain in-depth understanding of the disease prognosis. 相似文献
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