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The recent migration of 65,000 children across the southwestern border, coupled with allegations of abuse by the U.S. Border Patrol, enables the investigation of an overlooked immigrant category: the unaccompanied youth migrant. Analyzing audience responses to news reports of the abuse, we find that established disparaging immigrant tropes apply, describing the children as an economic burden, disease carriers, and offspring of irresponsible families. We uncover two new themes: Youth migrants are channels whereby criminals may infiltrate the U.S., and manipulate legal authorities to remain in the U.S. Finally, we demonstrate how global compassion is strategically deployed to qualify harsh retaliatory measures.  相似文献   
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Paralympic throwing events for athletes with physical impairments comprise seated and standing javelin, shot put, discus and seated club throwing. Identification of talented throwers would enable prediction of future success and promote participation; however, a valid and reliable talent identification battery for Paralympic throwing has not been reported. This study evaluates the reliability and validity of a talent identification battery for Paralympic throws. Participants were non-disabled so that impairment would not confound analyses, and results would provide an indication of normative performance. Twenty-eight non-disabled participants (13 M; 15 F) aged 23.6 years (±5.44) performed five kinematically distinct criterion throws (three seated, two standing) and nine talent identification tests (three anthropometric, six motor); 23 were tested a second time to evaluate test–retest reliability. Talent identification test–retest reliability was evaluated using Intra-class Correlation Coefficient (ICC) and Bland–Altman plots (Limits of Agreement). Spearman’s correlation assessed strength of association between criterion throws and talent identification tests. Reliability was generally acceptable (mean ICC = 0.89), but two seated talent identification tests require more extensive familiarisation. Correlation strength (mean rs = 0.76) indicated that the talent identification tests can be used to validly identify individuals with competitively advantageous attributes for each of the five kinematically distinct throwing activities. Results facilitate further research in this understudied area.  相似文献   
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Shear stress is the major mechanical force applied on vascular endothelial cells by blood flow, and is a crucial factor in normal vascular physiology and in the development of some vascular pathologies. The exact mechanisms of cellular mechano-transduction in mammalian cells and tissues have not yet been elucidated, but it is known that mechanically sensitive receptors and ion channels play a crucial role. This paper describes the use of a novel and efficient microfluidic device to study mechanically-sensitive receptors and ion channels in vitro, which has three independent channels from which recordings can be made and has a small surface area such that fewer cells are required than for conventional flow chambers. The contoured channels of the device enabled examination of a range of shear stresses in one field of view, which is not possible with parallel plate flow chambers and other previously used devices, where one level of flow-induced shear stress is produced per fixed flow-rate. We exposed bovine aortic endothelial cells to different levels of shear stress, and measured the resulting change in intracellular calcium levels ([Ca2+]i) using the fluorescent calcium sensitive dye Fluo-4AM. Shear stress caused an elevation of [Ca2+]i that was proportional to the level of shear experienced. The response was temperature dependant such that at lower temperatures more shear stress was required to elicit a given level of calcium signal and the magnitude of influx was reduced. We demonstrated that shear stress-induced elevations in [Ca2+]i are largely due to calcium influx through the transient receptor potential vanilloid type 4 ion channel.  相似文献   
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Hackett JM 《Endeavour》2002,26(2):70-74
The image of Roger Bacon as a 'modern' experimental scientist was propagated as historical truth in 19th century scientific historiography. Twentieth century criticisms attacked this tradition, arguing that Bacon was primarily a medieval philosopher with 'medieval' scientific interests. However, recent scholarship has provided a more careful and critical account of Bacon's science, and identifies his greatest achievement in terms of his successful attempt to assimilate the worlds of Greek and Islamic optics. It can be justly claimed that Roger Bacon was the first Western thinker in the middle ages to have mastered most of the Greek sources and the central Islamic source in optics. He made this scientific domain understandable for a Western Latin-reading audience. Yet, Bacon himself acknowledged Adelard of Bath, whose translations and commentary of Euclid's Elements set the foundations for a science of optics, as the true pioneer.  相似文献   
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The objective of this research study is to offer a glimpse into the lives of some newly-arrived students of different racial, linguistic and religious backgrounds as they confront the process of immigration and therefore personal and social displacement within the context of a Toronto inner-city high school. These students carry with them hidden but enduring scars that influence all aspects of their educational lives. In many cases their experience is steeped in trauma. Using auto-ethnographic methodology, this research is devoted to giving voice to these students who inhabit a space filled with suffering and loss but also resilience and cautious hope. If we really care about these vulnerable students in our classrooms, we must rethink and reshape our understanding of teaching and learning that is more fundamentally linked to the lived experiences of students coming from places of war and other oppressions. These issues are crucial for the future of nation-building and citizenship education in pluralistic Western societies such as Canada, both in and out of school.  相似文献   
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