Inducing chemotactic and haptotactic cues in microfluidic devices for three-dimensional in vitro assays

Microfluidic devices allow for the production of physiologically relevant cellular microenvironments by including biomimetic hydrogels and generating controlled chemical gradients. During transport, the biomolecules interact in distinct ways with the fibrillar networks: as purely diffusive factors in the soluble fluid or bound to the matrix proteins. These two main mechanisms may regulate distinct cell responses in order to guide their directional migration: caused by the substrate-bound chemoattractant gradient (haptotaxis) or by the gradient established within the soluble fluid (chemotaxis). In this work 3D diffusion experiments, in combination with ELISA assays, are performed using microfluidic platforms in order to quantify the distribution of PDGF-BB and TGF-β₁ across collagen and fibrin gels. Furthermore, to gain a deeper understanding of the fundamental processes, the experiments are reproduced by computer simulations based on a reaction-diffusion transport model. This model yields an accurate prediction of the experimental results, confirming that diffusion and binding phenomena are established within the microdevice.     

体育规则：足球规则修改与集体项目规则的比较研究

本文以法学视角,尤其是国际法视角,通过研读规则文本的方式,对足球规则的演进进行分析,并且揭示一些目前体育法领域关注的问题:体育法(lex sportiva)确实存在,包含了公法部分(国际公约、国家立法)和私法部分(体育规则);体育规则(Laws of the game)是体育法的核心,包括国家、地区以及全球范围内各级体育主管部门的章程与条例;项目规则是体育法的另一个重要核心,作者以足球为例,论证了为什么项目规则也是法的问题。     

Lacrosse History,a History of One Sport or Two? A Comparative Analysis of Men's Lacrosse and Women's Lacrosse in the United States

Men's lacrosse and women's lacrosse share a name, but their histories differ. Both sports developed and became organised in close concert with the race, class and gender expectations of the eras. As a result, the sports began with rules that reflected those norms. Over time, the sports developed separately and generated unique forms, even as they sustained moments of interaction. Therefore, men's lacrosse and women's lacrosse are different sports. Using comparisons as the mode through which to view the sports, this article explores the organised beginnings of men's lacrosse and women's lacrosse to establish that the sports began and continued within identity-based norms. Through the discussion of the practical distinctions and critical understandings of the differences between the games, the author poses that these dissimilarities are relevant in considerations of the separate sports as they continue to change in the larger US sporting context. As sports such as basketball demonstrate, these arguments matter because broad-scale comparisons of women's sports to men's frequently render women's sport participants, and the sports they play, inferior. Notably, women's lacrosse participants also employed comparisons to distinguish and claim their history as unique from that of men's lacrosse. A comparative analysis highlights points of disjuncture between the sports and contextualises the importance of gender in the articulations of difference.     

The impact of childhood foster care and other out-of-home placement on homeless women and their children

OBJECTIVE: This study compares homeless women who had childhood histories of foster care or other out-of-home placement to those who have not. METHOD: A countywide probability sample of homeless women (n = 179) received structured interviews. RESULTS: One-third of homeless women reported being raised apart from their parents. Among women with children under age 18, most (61.5%) had children who had lived in foster care or other out-of-home placements. Variables associated with homeless mothers' children living in foster care or other out-of-home placements were: Child was school-age, mother was age 35 or older, mother had a current alcohol or drug use disorder, mother experienced childhood sexual abuse, and mother ran away from home (when under age 18). CONCLUSIONS: Parenting is difficult for homeless mothers who may need to place their children with others to facilitate school attendance. Parent-child interaction may be problematic in family shelters where privacy is rare. Thus, programs promoting family preservation for homeless mothers should provide parenting support as well as permanent housing.     

Contextualizing the effects of childhood sexual abuse on adult self- and social functioning: an attachment theory perspective

OBJECTIVE: This retrospective survey study explored the hypothesis that multiple maltreatment and loss experiences in early childhood would interfere with the formation of secure attachments, creating (1) an increased vulnerability to childhood sexual abuse (CSA), and (2) adult problems in self- and social functioning. METHOD: Data were collected from 687 undergraduates on an urban, commuter campus. They were analyzed by means of between group (individuals with and without CSA histories) and within group (individuals with CSA histories) path analytic models. RESULTS: The number of maltreatment and loss experiences encountered in early childhood predicted greater CSA frequency in childhood and increased maltreatment in adulthood in the form of more frequent reports of sexual, physical, and emotional abuse. Childhood maltreatment and loss experiences also predicted poor adult self-functioning in the form of higher levels of depression and lower levels of self-esteem. Self-blame in response to CSA and maltreatment in adult relationships also predicted poorer adult self- and social functioning for individuals with CSA histories. CONCLUSIONS: Findings support both direct and mediational effects of childhood maltreatment and loss experiences on adult self- and social functioning and are consistent with predictions derived from attachment theory.     

浅析高校学生终身体育锻炼习惯的培养

分析探讨了培养学生终身体育锻炼习惯的途径和方法。即加强体育锻炼基本知识的传授，培养兴趣，激发动机，培养意志品质及自学能力等。     

Excitement and Representation: Toward a Sociological Explanation of the Significance of Sport in Modern Society

It is suggested that sport is not only popular but also plays a highly significant part in the lives of many. One explanation focuses on the analysis of the tension excitement generated by sporting encounters. Particular emphasis is placed on the work of Elias and Dunning, who suggest that in societies at a late stage in the “civilising process,” affect-control is strongly established, so that people's expressions of sentiment are strongly restrained. Excitement in such societies is thus to be found not so much in real-life situations as through mimetic or “imitative” excitement, which resembles that produced in critical situations in real life, but in a safe and pleasurable way. A second approach draws on a variety of theoretical perspectives, although the contributions derived from Emile Durkheim's later work on the sociology of religion are prominent. The argument is advanced that sports encapsulate symbolically the social natures, relations, and identities of the collectivities that generate them. Sport, therefore, is perceived as a form of collective representation that may be invested with great social significance. Finally, relationships between the two approaches are considered.     

Scientific arguments as learning artifacts: designing for learning from the web with KIE

We designed Knowledge Integration Environment (KIE) debate projects to take advantage of internet resources and promote student understanding of science. Design decisions were guided by the Scaffolded Knowledge Integration instructional framework. We report on design studies that test and elaborate on our instructional framework. Our learning studies assess the arguments students construct using the Knowledge Integration Environment debate project about light propagation and, explore the relationship between students' views of the nature of science and argument construction. We examine how students use evidence, determine when they add further ideas and claims and measure progress in understanding light propagation. To a modeate degree, students' views of the nature of science align with the quality of the arguments.