Robust fluidic connections to freestanding microfluidic hydrogels

Biomimetic scaffolds approaching physiological scale, whose size and large cellular load far exceed the limits of diffusion, require incorporation of a fluidic means to achieve adequate nutrient/metabolite exchange. This need has driven the extension of microfluidic technologies into the area of biomaterials. While construction of perfusable scaffolds is essentially a problem of microfluidic device fabrication, functional implementation of free-standing, thick-tissue constructs depends upon successful integration of external pumping mechanisms through optimized connective assemblies. However, a critical analysis to identify optimal materials/assembly components for hydrogel substrates has received little focus to date. This investigation addresses this issue directly by evaluating the efficacy of a range of adhesive and mechanical fluidic connection methods to gelatin hydrogel constructs based upon both mechanical property analysis and cell compatibility. Results identify a novel bioadhesive, comprised of two enzymatically modified gelatin compounds, for connecting tubing to hydrogel constructs that is both structurally robust and non-cytotoxic. Furthermore, outcomes from this study provide clear evidence that fluidic interconnect success varies with substrate composition (specifically hydrogel versus polydimethylsiloxane), highlighting not only the importance of selecting the appropriately tailored components for fluidic hydrogel systems but also that of encouraging ongoing, targeted exploration of this issue. The optimization of such interconnect systems will ultimately promote exciting scientific and therapeutic developments provided by microfluidic, cell-laden scaffolds.     

The Effects of Parental Behavior on Infants' Neural Processing of Emotion Expressions

Infants become sensitive to emotion expressions early in the 1st year and such sensitivity is likely crucial for social development and adaptation. Social interactions with primary caregivers may play a key role in the development of this complex ability. This study aimed to investigate how variations in parenting behavior affect infants' neural responses to emotional faces. Event‐related potentials (ERPs) to emotional faces were recorded from 40 healthy 7‐month‐old infants (24 males). Parental behavior was assessed and coded using the Emotional Availability Scales during free‐play interaction. Sensitive parenting was associated with increased amplitudes to positive facial expressions on the face‐sensitive ERP component, the negative central. Findings are discussed in relation to the interactive mechanisms influencing how infants neurally encode positive emotions.     

‘I’m just a numbers person’: the complexity,nature and effects of the quantification of education

This paper draws upon the sociology of numbers, particularly work by Theodore Porter, to reveal the multifarious ways in which numbers actively constitute practices in schools. Drawing upon a case study of one low-performing school in a low-performing region in the state of Queensland, Australia, and theorising into the sociology of numbers, the research explores the complex ways in which numbers came to constitute and dominate the practices in this school site under a broader national, state and regional policy context demanding rapid improvements in various forms of standardised tests and associated practices. Specifically, the research reveals a strong and simultaneous focus by teachers upon a variety of numeric data collected at national, regional and local levels, and intricate relations between these data; multiple visualisation, triangulation and comparison approaches towards such data in virtual and physical formats; and the enumerative nominalisation of both students and their reading attainment in relation to specific, concretised levels of achievement and various types of scale scores. The research cautions against the sheer volume of such enumerative practices, which, while productive of teachers’ understandings of student capacity against standardised measures of achievement, may also lead to a more reductive view of education, dominated by concerns about achievement in standardised tests (and associated practices) alone.     

Estimation of a Nonlinear Intervention Phase Trajectory for Multiple-Baseline Design Data

A multilevel logistic model for estimating a nonlinear trajectory in a multiple-baseline design is introduced. The model is applied to data from a real multiple-baseline design study to demonstrate interpretation of relevant parameters. A simple change-in-levels (ΔLevels) model and a model involving a quadratic function (Quadratic) for the nonlinear intervention phase data were also estimated. In addition, a simulation study was conducted to assess Markov chain Monte Carlo estimation of the logistic model and compare its trajectory recovery with use of the ΔLevels and Quadratic models. While most of the logistic model's parameter values were recovered well, trajectory recovery was very reasonable using the simpler Quadratic model. Results are discussed along with recommendations for practitioners and directions for future research.     

Education as a ‘risky business’: Theorising student and teacher learning in complex times

This paper employs sociological literature on risk and the commodification of education to explain current schooling practices in a context of increased concerns about students’ behaviour and results on standardised tests of achievement. Drawing upon teacher and student learning practices in three school sites in south-east Queensland, Australia, the article reveals how specific tests, packages and programmes have been employed as technologies of governance to minimise the risk of adverse student behaviour, maximise student outcomes on standardised tests, and provide teachers with discrete learning experiences construed as improving such outcomes. The sum total of these foci is the construction of education as an increasingly ‘risky business’ which employs a myriad of products and tests to manage perceived and actual risks. The paper also reveals how these products and processes constitute student misbehaviour and inadequate teacher and student learning as ‘risk objects’ requiring constant intervention, but which also inhibit inclusion in schooling settings, and challenge teachers’ professionalism.     

The role of work-related learning in the identity transformation of Canadian workers with low literacy skills

Workplaces are settings where power, knowledge and self are brought together in a complex social environment which includes various forms of struggle related to identity, agency, socio-cultural norms, political structures and functional practices. The purpose of this article is to uncover how formal and informal work-related learning processes influence the identity transformation of workers with low literacy and essential skills. Drawing on two recent Canadian data bases which serve as cases in this study, the position taken by the authors is that the organisational context can both facilitate and impede worker subjectivity. Various conditions, approaches to learning and training pathways are examined as they contribute to social cognitive and transformative learning theories.     

The Student Perception of Wellbeing Questionnaire: Preliminary Investigation into its Psychometric Properties

An estimated 20% of all adolescents will experience a depressive disorder by the age of 18, with schools being at the forefront of initiatives to promote resilience and well-being. This study reports on the development of the 24-item Student Perception of Wellbeing Questionnaire (SPWQ), created as a measure of well-being in three areas: exercise, explanatory style, and conflict resolution. The SPWQ was administered to 235 male school students from Years 6–8 and 251 female students from Years 7–9, and a principal components analysis with varimax rotation was performed on the data obtained. A three-factor solution was identified dealing with explanatory style, conflict resolution, and exercise, which explained 31% of the total variance. The scale was found to have strong internal consistency with a Cronbach alpha coefficient of α = 0.80 for the male students and α = 0.84 for the female students.