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21.
Stanislava Petrovic Natasa Bogavac-Stanojevic Dragana Lakic Amira Peco-Antic Irena Vulicevic Ivana Ivanisevic Jelena Kotur-Stevuljevic Zorana Jelic-Ivanovic 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(2):262-271
Introduction
Acute kidney injury (AKI) is significant problem in children with congenital heart disease (CHD) who undergo cardiac surgery. The economic impact of a biomarker-based diagnostic strategy for AKI in pediatric populations undergoing CHD surgery is unknown. The aim of this study was to perform the cost effectiveness analysis of using serum cystatin C (sCysC), urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine liver fatty acid-binding protein (uL-FABP) for the diagnosis of AKI in children after cardiac surgery compared with current diagnostic method (monitoring of serum creatinine (sCr) level).Materials and methods
We developed a decision analytical model to estimate incremental cost-effectiveness of different biomarker-based diagnostic strategies compared to current diagnostic strategy. The Markov model was created to compare the lifetime cost associated with using of sCysC, uNGAL, uL-FABP with monitoring of sCr level for the diagnosis of AKI. The utility measurement included in the analysis was quality-adjusted life years (QALY). The results of the analysis are presented as the incremental cost-effectiveness ratio (ICER).Results
Analysed biomarker-based diagnostic strategies for AKI were cost-effective compared to current diagnostic method. However, uNGAL and sCys C strategies yielded higher costs and lower effectiveness compared to uL-FABP strategy. uL-FABP added 1.43 QALY compared to current diagnostic method at an additional cost of $8521.87 per patient. Therefore, ICER for uL-FABP compared to sCr was $5959.35/QALY.Conclusions
Our results suggest that the use of uL-FABP would represent cost effective strategy for early diagnosis of AKI in children after cardiac surgery.Key words: acute kidney injury, cardiac surgery, children, biomarkers, cost effectiveness analysis 相似文献22.
Existing research indicates that emotions are integral components of teachers’ jobs and lives, but knowledge regarding functional relations between teachers’ emotions, their antecedents and their effects on teachers, teaching and students is still quite scarce. One possible reason for this knowledge gap is the lack of adequate operationalisation of the teacher-emotion construct. Thus, the aim of this research was to develop a psychometrically grounded and contextually specific multidimensional self-report instrument aimed at assessing the specific emotions teachers experience in relation to their work and profession. Based on the contemporary component definition of emotion, and using a mixed-method approach (qualitative and quantitative), through a series of five empirical studies (N1 = 25, N2 = 300, N3 = 315, N4 = 391 and N5 = 1314), the Teacher Emotion Questionnaire (TEQ) has been developed. The instrument contains scales assessing emotions of joy, pride, love, fatigue, anger and hopelessness. All scales have adequate psychometric characteristics and are theoretically meaningfully related to the criterion variables examined. Added value of the TEQ scales over the more general measures of affect is also demonstrated. 相似文献
23.
Guillaume Mottet Karla Perez-Toralla Ezgi Tulukcuoglu Francois-Clement Bidard Jean-Yves Pierga Irena Draskovic Arturo Londono-Vallejo Stephanie Descroix Laurent Malaquin Jean Louis Viovy 《Biomicrofluidics》2014,8(2)
We present a low cost microfluidic chip integrating 3D micro-chambers for the capture and the
analysis of cells. This device has a simple design and a small footprint. It allows the
implementation of standard biological protocols in a chip format with low volume consumption. The
manufacturing process relies on hot-embossing of cyclo olefin copolymer, allowing the development of
a low cost and robust device. A 3D design of microchannels was used to induce high flow velocity
contrasts in the device and provide a selective immobilization. In narrow distribution channels, the
liquid velocity induces a shear stress that overcomes adhesion forces and prevents cell
immobilization or clogging. In large 3D chambers, the liquid velocity drops down below the threshold
for cell attachment. The devices can be operated in a large range of input pressures and can even be
handled manually using simple syringe or micropipette. Even at high flow injection rates, the 3D
structures protect the captured cell from shear stress. To validate the performances of our device,
we implemented immuno-fluorescence labeling and Fluorescence in Situ Hybridization
(FISH) analysis on cancer cell lines and on a patient pleural effusion sample. FISH is a Food and
Drug Administration approved cancer diagnostic technique that provides quantitative information
about gene and chromosome aberration at the single cell level. It is usually considered as a long
and fastidious test in medical diagnosis. This process can be easily implanted in our platform, and
high resolution fluorescence imaging can be performed with reduced time and computer intensiveness.
These results demonstrate the potential of this chip as a low cost, robust, and versatile tool
adapted to complex and demanding protocols for medical diagnosis. 相似文献
24.
When looking for answers to the question of academic (non)achievement of regular pupils and pupils with special needs, it is necessary to take into account the extraordinary complexity of factors, ranging from psychological across instructional to home environment variables. The academic achievement is not only a reflection of the pupil’s knowledge, but is also influenced by the pupil’s behaviour, the teacher’s expectations and finally the relationship established between the teacher and the pupil. This paper contributes answers to the question which of the traits, perceived by teachers, explain the academic achievements of regular pupils and pupils with special needs. Our analysis shows that perceived traits that explain the academic achievement of regular pupils refer to academic as well as social behaviour, disruptive behaviour and self-regulatory behaviour; therefore, they cover all areas of perceived traits we studied. In pupils with special needs as a whole and in particular groups of pupils with special needs, the factor which presents disruptive social behaviour proved as insignificant, which consequently means that the academic achievement of pupils with special needs depends more on academic and self-regulatory behaviour, task activity and social inclusion. 相似文献
25.
Teachers’ perceptions of the inclusion of marginalised groups 总被引:1,自引:0,他引:1
This paper is based on the concept of inclusion as a process of recognising and minimising the barriers to learning and participation of all children, with teachers as the key players in implementing inclusion in practice. There are two key questions: (1) How do teachers rank different groups of marginalised children? (2) How do teachers see their own role, the role of the marginalised and other children, and their parents in the inclusion process? The groups included in the research were children with special needs, migrants from former Yugoslavia, Roma/Gypsies and children from poor families. In the latter group, it also looked at their counterparts, the children of wealthy parents. Research carried out on a representative sample of primary school teachers in Slovenia showed that children with special needs are among all surveyed groups of children those seen as the most helpless. For these children, teachers are also most likely to lower learning and discipline standards, while at the same time feeling the least qualified to teach them and seeing them also as having the lowest abilities. In the teachers’ opinion, parents of other children have the greatest reservations when their child associates with a Roma/Gypsy child, and teachers also put the least trust in Roma/Gypsy parents. 相似文献
26.
Irena Pufal‐Struzik 《High Ability Studies》1995,6(1):53-59
A total of 80 students aged seventeen and eighteen (40 in each group) selected from several secondary schools took part in the study. It was assumed that the intensity of self‐acceptance among gifted young people is positively influenced by intellectual success, as well as by the following personality traits: internal locus of control, average or low level of anxiety, strong sensation seeking. There was a trend towards higher self‐actualization among gifted students (although statistically insignificant), while self‐actualizing students had an internal locus of control and a need for stimulation and varied experience. The assumption that lower anxiety and higher self‐acceptance are characteristic of young people with higher self‐actualization was not confirmed, which suggests that there is a need to intensify parents' and teachers' support for students coping with difficulties. 相似文献
27.
Benjamin Bartl Jiří Trejbal Michal Ďurovič Soňa Vašíčková Irena Valterová 《Journal of Cultural Heritage》2012,13(3):275-284
Thirteen samples of an efflorescence collected from the surface of beeswax seals or from beeswax used for their restoration were analysed in detail. The samples were of different origin, age and storage history. The composition and the incidence of the efflorescence was correlated with a chemical composition of historical and recent beeswax samples. The composition of the crystalline layer was found to be very similar in all the samples. Linear monounsaturated alkenes containing 31 and 33 carbon atoms, more precisely (Z)-hentriacont-10-ene and (Z)-tritriacont-10-ene, were identified as main components. The analyses of beeswax have revealed that all compounds identified in “wax bloom” naturally occur in recent beeswax. However, the historical beeswaxes contained only traces of unsaturated hydrocarbons, if anything. The efflorescence was observed primarily on the surfaces of those samples which contained larger proportion of alkenes. The presented results could be of particular importance not only for better understanding of the described phenomenon, but also for the development of new beeswax-based materials, which would be “bloom resistant” and useful for conservation purposes. 相似文献
28.
Irena Lesar 《International Journal of Inclusive Education》2018,22(7):699-713
In the research in the field of inclusiveness it is often neglected how inclusiveness is constructed differently within the so-called Anglo-American and continental educational contexts. In Slovenia, the field of educational studies has historically developed within the continental, particularly German tradition, as a discipline called Pedagogy at the Faculty of Arts. Since Pedagogy is fundamentally theorising the processes of becoming a free human being and does not take a particular interest in the issues of vulnerable social groups, a complementary area of tertiary study emerged in today's Faculty of Education (e.g. Special needs Pedagogy). However, recently we can identify a trend of emerging new study programmes, the so-called inclusive education. Because of this separation between scientific fields, this paper is dealing with a question of which of the disciplines is offering a more convincing answers to the question of how to conceptualise and implement the inclusiveness. Using qualitative analyses of the concept of inclusiveness and content analyses of Slovenian study programmes and courses related to inclusive education, we attempt to show that discipline of Pedagogy provides a conceptualising of inclusiveness that is more complex through successfully interweaving the humanistic and social paradigm. 相似文献
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30.
Historic parchment is a complex biological material, and due to various methods of production or inks used, unknown environmental histories of objects and heterogeneous nature of animal skin, it represents a particular analytical challenge. Due to the number of variables it is likely that patterns in degradation of these historic objects can only be revealed by surveying the material properties of a significant number of real objects. In this work, a sacrificial collection of ca. 100 historic parchments (fifteenth to twentieth century) was characterized using a range of techniques available to conservation practitioners that can usefully be used to reliably and rapidly characterize parchment. We focused on micro-destructive methods, such as shrinkage temperature (Ts), as the most widely used indicator of parchment degradation. Lipid content, roughness, and ink pH were additionally measured, while a limited number of samples containing iron gall ink were also examined using scanning electron microscopy (SEM) and SEM-EDX, to explore the distribution of ink components. Even in the absence of detailed environmental histories, it is possible to acknowledge the significance of the effect of iron gall ink and its acidity, and of lipids on parchment degradation, as measured using Ts. This research reports valuable reference data, while the collection remains accessible for further research. 相似文献