Evaluation of immunohistochemistry and enzyme linked immunosorbent assay for HER-2/neu expression in breast carcinoma

HER-2 is overexpressed in approximately 20–30% of invasive Breast Cancer. ECD of the HER-2 protein is frequently cleaved and released into the circulation, where it can be detected by ELISA in up to 45% of patients with metastatic breast cancer. The objective of our study was to compare the current methods for the detection of HER-2 protein. Tissue HER-2 levels were studied in 100 breast cancer patients by IHC and compared with serum HER-2 levels by ELISA. IHC frequency was 29%. Serum HER-2 ECD was positive in 42% of patients. A statistically significant correlation was observed. HER-2 detected by IHC correlates significantly with serum HER-2 levels detected by ELISA. Thus, ELISA is a reliable and economical tool to assess the HER-2 status in tumors, when breast tissue sample is not available.     

The private finance initiative, project form and design innovation: The UK's hospitals programme

This paper discusses the role of public demand, in the form of a government procurement policy, in generating innovative solutions for healthcare infrastructure. It considers the effects of the project delivery system (planning, finance, construction and operation) for new hospitals on design innovation. It focuses on hospitals built under the UK's private finance initiative (PFI), which was partly introduced to inject increased innovation into hospital delivery. We use case studies of six early PFI hospitals to argue that the introduction of PFI has increased the complexity at the interface between project delivery and hospital operational functions. The result is a project delivery model which yields less innovative outcomes and produces facilities that might not be able to cope with future changes in demand. The paper suggests that new public procurement models do not automatically provide efficiency and innovation benefits.     

Research: Students' Perceptions of Need for Personal Counseling Services in Community Colleges

Although the need for personal counseling services is on the rise across college campuses in the United States, many community colleges do not offer personal counseling services on campus. Instead, community college counseling services focus primarily on academic and career advising. The purpose of this study was to survey community college students in North Carolina to determine their interest in and need for a personal counseling center on campus. Participants were 134 men and 202 women, 18–68 years of age. Of the participants, 70% indicated that having a personal counseling center on campus would be “very helpful” or “helpful.” Results are discussed, and recommendations are made for college counselors working in community college settings.     

Non-Traditional Students in Australian Higher Education: Persistent Inequities and the New Ideology of `Student Choice'

Despite the expansion of access toAustralian higher education in the past decade, theparticipation shares of rural and isolated people andpeople from lower socioeconomic backgrounds havealtered little and remain unacceptably low. Thispaper reports findings from two national studies atthe Centre for the Study of Higher Education that haveexamined student choices about higher education,especially the inhibiting factors still present fornon-traditional students. The discussion focuses onthe dilemmas and challenges for Australianuniversities in balancing the adoption ofentrepreneurial approaches to student recruitment withan unfinished equity agenda. The paper raisesquestions about the new ideology of individual choiceinfluencing university policy and whether or not thiscan be reconciled with social equity objectives.     

ISI数据库——学术期刊及网站的选择

ISI（美国科学信息研究所）的基本任务是向其用户提供所需要的世界最重要、最有影响的期刊收录信息,ISI数据库不仅可以检索当年而且可追溯以往。现有数据库收录自然科学、社会科学、艺术与人文科学的国际期刊8500余种。ISI能完整地检索它所收录的任何一条文献数据。期刊的评估与选择是动态过程,每年ISI数据库的来源期刊都会有所增加或删减。每种期刊在被录用或被淘汰前都经过内容广泛的评估过程。ISI数据库期刊评估要考虑多种因素,评估范围从质到量标准不同,包括基本出版标准、学术内容、作者的国际化程度,及其与之相关的引文     

1972 Revision of the Stanford-Binet: A farewell to the mental age

Inspection of the 1972 revised norms for the Stanford-Binet demonstrate that the average mental age for a particular CA no longer numerically corresponds to that CA. Thus, mental ages derived from the test cannot any longer be interpreted as mental ages. A table of test ages based on the 1972 norms is provided.     

Impaired motor control after sport-related concussion could increase risk for musculoskeletal injury: Implications for clinical management and rehabilitation

This review presents a conceptual framework and supporting evidence that links impaired motor control after sport-related concussion(SRC)to increased risk for musculoskeletal injury.Multiple studies have found that athletes who are post-SRC have higher risk for musculoskeletal injury compared to their counterparts.A small body of research suggests that impairments in motor control are associated with musculoskeletal injury risk.Motor control involves the perception and processing of sensory information and subsequent coordination of motor output within the central nervous system to perform a motor task.Motor control is inclusive of motor planning and motor learning.If sensory information is not accurately perceived or there is interference with sensory information processing and cognition,motor function will be altered,and an athlete may become vulnerable to injury during sport participation.Athletes with SRC show neuroanatomic and neurophysiological changes relevant to motor control even after meeting return to sport criteria,including a normal neurological examination,resolution of symptoms,and return to baseline function on traditional concussion testing.In conjunction,altered motor function is demonstrated after SRC in muscle activation and force production,movement patterns,balance/postural stability,and motor task performance,especially performance of a motor task paired with a cognitive task(i.e.,dual-task condition).The clinical implications of this conceptual framework include a need to intentionally address motor control impairments after SRC to mitigate musculoskeletal injury risk and to monitor motor control as the athlete progresses through the return to sport continuum.