Raised serum homocysteine levels in patients of coronary artery disease and the effect of vitamin B12 and folate on its concentration

Homocysteine(Hcy) has been implicated as a novel risk factor of Coronary Artery Disease (CAD) among Asian Indians, but many studies done in India failed to reveal any direct correlation. It has also been reported that Folic acid and Vitamin B12 levels inversely affect serum levels of homocysteine. In this study, we looked at the levels of homocysteine among patients with CAD. The effect of Vitamin B12, Folate and other risk factors on homocysteine levels were also evaluated. Mean homocysteine levels in cases (22.81±13.9, n=70) were significantly higher (p=<0.001) than the controls (7.77±7.3, n=70). However no statistically significant correlation could be deduced between homocysteine Vitamin B12, and Folate. Cumulative analysis have indicated an increase in homocysteine levels among patients with CAD with every additional risk factor.     

Troponin T and Heart Type Fatty Acid Binding Protein (h-Fabp) as Biomarkers in Patients Presenting with Chest Pain

Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP.     

A review of ontology based query expansion

This paper examines the meaning of context in relation to ontology based query expansion and contains a review of query expansion approaches. The various query expansion approaches include relevance feedback, corpus dependent knowledge models and corpus independent knowledge models. Case studies detailing query expansion using domain-specific and domain-independent ontologies are also included. The penultimate section attempts to synthesise the information obtained from the review and provide success factors in using an ontology for query expansion. Finally the area of further research in applying context from an ontology to query expansion within a newswire domain is described.     

Liquid–Liquid Extraction and Solid Phase Extraction for Urinary Organic Acids: A Comparative Study from a Resource Constraint Setting

Pre analytical process of extraction for accurate detection of organic acids is a crucial step in diagnosis of organic acidemias by GCMS analysis. This process is accomplished either by solid phase extraction (SPE) or by liquid–liquid extraction (LLE). Both extraction procedures are used in different metabolic laboratories all over the world. In this study we compared these two extraction procedures in respect of precision, accuracy, percent recovery of metabolites, number of metabolites isolated, time and cost in a resource constraint setup. We observed that the mean recovery from SPE was 84.1 % and by LLE it was 77.4 % (p value <0.05). Moreover, the average number of metabolites isolated by SPE and LLE was 161.8 ± 18.6 and 140.1 ± 20.4 respectively. The processing cost of LLE was economical. In a cost constraint setting using LLE may be the practical option if used for organic acid analysis.     

When do incumbents learn from entrepreneurial ventures?: Corporate venture capital and investing firm innovation rates

In this paper, we focus on the potential innovative benefits to corporate venture capital (CVC), i.e. equity investments in entrepreneurial ventures by incumbent firms. We propose that corporate venture capital programs may be instrumental in harvesting innovations from entrepreneurial ventures and thus an important part of a firm's overall innovation strategy. We hypothesize that these programs are especially effective in weak intellectual property (IP) regimes and when the firm has sufficient absorptive capacity. We analyze a large panel of public firms over a 20-year period and find that increases in corporate venture capital investments are associated with subsequent increases in firm patenting.     

Secondary immunization inhibits drug induced apoptosis<Emphasis Type="Italic">in vivo</Emphasis>

Immunization with a proper dose of an antigenic stimulus leads to cell proliferation and antibody response of circulating lymphocytes. We have previously observed that Secondary immunized spleenocytes resist ceramide-mediated apoptosisin vitro. Our present study is aimed at investigating thein vivo effect of immunization on apoptosis. Mice were subjected to either Primary or Secondary dose with Tetanus Toxoid. Unimmunized spleenocytes served as controls. Unimmunized, Primary and Secondary immunized mice were later exposed to chemotherapeutic drugs such as Etoposide/Methotrexate/Vincristine to induce apoptosis. Apoptosis was studied by using the Feulgen reaction on 5μ thin parafin sections of spleen. It was observed that Secondary immunized mice showed a lower percentage of apoptosis as compared to Primary or Unimmunized mice that was subjected to either of the chemotherapeutic drugs. It was thus concluded that Secondary immunization inhibits the process of chemotherapeutic drug induced apoptosis in vivo.     

Neutralization theory and online software piracy: An empirical analysis

Accompanying the explosive growth of information technology is the increasing frequency of antisocial and criminal behavior on the Internet. Online software piracy is one such behavior, and this study approaches the phenomenon through the theoretical framework of neutralization theory. The suitability and applicability of nine techniques of neutralization in determining the act is tested via logistic regression analyses on cross-sectional data collected from a sample of university students in the United States. Generally speaking, neutralization was found to be weakly related to experience with online software piracy; other elements which appear more salient are suggested and discussed in conclusion.     

Deep Participation in Underserved Communities: A Quantitative Analysis of Hearken’s Model for Engagement Journalism

ABSTRACT

Hearken is a proprietary news engagement platform growing in popularity. Under the Hearken approach, audience members are invited to participate in the newsmaking process. Hearken strives to assist news organizations in providing local and hyperlocal content that meets audience needs and demands while preserving elements of the journalist’s role as gatekeeper. Hearken has also worked to help news organizations reach underrepresented populations with mixed results per its own anecdotal analyses. This study employs a quantitative content analysis comparing one year’s worth of coverage at four different local NPR affiliates in the United States to provide a breakdown of Hearken content versus traditional reporter-driven content in the following four categories: emphasis on hyperlocal coverage, story topic prevalence within local and hyperlocal coverage, emphasis on coverage of underrepresented communities, and story topic prevalence within coverage of underrepresented communities. Findings reveal listener-driven Hearken content favors hyperlocal news on lifestyle issues while reporter-driven stories emphasize state-level governance and politics as well as local crime. These indicate a stark contrast between the content audiences want and that which journalists tend to report. The nuanced normative implications, possibilities and limitations of Hearken’s model of “deep participation” are addressed in some detail.     

A new unsupervised method for document clustering by using WordNet lexical and conceptual relations

Text document clustering provides an effective and intuitive navigation mechanism to organize a large amount of retrieval results by grouping documents in a small number of meaningful classes. Many well-known methods of text clustering make use of a long list of words as vector space which is often unsatisfactory for a couple of reasons: first, it keeps the dimensionality of the data very high, and second, it ignores important relationships between terms like synonyms or antonyms. Our unsupervised method solves both problems by using ANNIE and WordNet lexical categories and WordNet ontology in order to create a well structured document vector space whose low dimensionality allows common clustering algorithms to perform well. For the clustering step we have chosen the bisecting k-means and the Multipole tree, a modified version of the Antipole tree data structure for, respectively, their accuracy and speed.