Digital games pre-schoolers play: parental mediation and examination of educational content

Education and Information Technologies - The aim of this study is to examine mediations of parents who make digital games played by 60–72 months old children accessible, and the...     

Oxidatively Damaged DNA: A Possible Antigenic Stimulus for Cancer Autoantibodies

Reactive oxygen species (ROS) are cytotoxic at higher concentration resulting in cell death, mutations, chromosomal aberrations or carcinogenesis. In this study DNA was modified by singlet oxygen and superoxide anion radicals generated by illumination of riboflavin under 365 nm UV-light. The modified DNA induced high titre antibodies in experimental animals. In enzyme immunoassay, serum antibodies from cancer patients (n = 34) showed a higher recognition of the modified DNA, as compared to the native form. This was further confirmed by the gel-shift assay. Immune IgG were used as a probe to detect oxidative lesions in the DNA of cancer patients. DNA isolated from lymphocytes of cancer patients proved to be an appreciable inhibitor of the experimentally induced antibodies against the ROS-DNA. This indicates the presence of oxidative lesions in the DNA obtained from cancer patients. The results show that ROS induced oxidative damage to DNA in cancer patients generate neo-epitopes that are alien for the immune system, resulting in autoantibody formation.     

Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome

The present study was designed to test the hypothesis of a circadian variation in circulating levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS). Serum levels of IL-6 and TNF-α were measured at 4 h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68 ± 9.89) as well as 50 healthy control women (age 32.82 ± 10.53). Serum TNF-α levels were substantially increased in patients with FMS but showed no circadian variation. In contrast, no difference in the levels of IL-6 was found. Moreover, there was also no circadian variation in both the groups of patients and controls. We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-α in patients with FMS, although TNF-α levels are found raised in patients with FMS.     

Bilingual language proficiency: A comparative study

International Review of Education -     

Voices of home and school on democracy and human rights education at the primary level: a case study

The purpose of this research was to investigate the perceptions of home and school concerning ideally implemented primary democracy and human rights education. In this qualitative study, data were collected from six voluntary classroom teachers and 16 parents in a selected school through interviews. The results of the interview yielded five major themes: physical and environmental issues, instructional process, teacher characteristics, assessment practices, and communication patterns for teaching democracy and human rights ideally. Most of the participants also indicated the lack of partnership between home and school. The results showed that there are gaps between the existing and desired conditions of democracy and human rights education in schools.     

Hydro-Alcoholic Cinnamon Extract, Enhances Glucose Transporter Isotype-4 Translocation from Intracellular Compartments into the Cytoplasmic Membrane of C2C12 Myotubes

Cinnamon has been used as an anti-diabetic agent for centuries but only in recent few years its mechanism of action has been under investigation. Previous studies showed that cinnamon might exert its anti-diabetic effect via increasing glucose transporter isotype-4 (GLUT4) gene and glycoprotein contents in fat cells. To study if hydro-alcoholic cinnamon extract (HACE) enhances GLUT4 translocation from intracellular compartments of nuclear or endoplasmic reticulum membranes (N/ER) into the cytoplasmic membrane (CM). C2C12 myoblastic cell line were seeded in DMEM plus 20 % FBS and differentiated to myotubes using 2 % horse serum. After myotubes formation, 100 or 1,000 μg/ml HACE, as intervention, and as control 1 % DMSO were added for 3 h. Cells were washed and homogenized followed by ultracentrifuge fractionation, protein separation by SDS-PAGE and GLUT4 detection using semi-quantitative Western blotting. Data analysis was done by two-independent samples t test for comparison of mean ± SD of GLUT4 percent in categories. GLUT4 contents were higher in CM of groups 100 and 1,000 μg/ml HACE and lower in 1 % DMSO treated myotubes (CI = 0.95, P < 0.05). For N/ER reverse results were obtained (CI = 0.95, P < 0.05). As our results have shown HACE induces GLUT4 translocation from intra-cell into cell surface. We conclude that cinnamon maybe a choice of type-2 diabetes mellitus treatment because its extract enhances GLUT4 contents in CM where it facilitates glucose entrance into the cell. However it is necessary to trace the signaling pathways which are activated by HACE in muscular tissue.     

A Community-Driven Metadata Framework for Describing Cultural Resources: The Digital Library North Project

This article describes the Digital Library North (DLN) project, a collaboration among researchers at the University of Alberta, staff at the Inuvialuit Cultural Resource Centre, and communities within the Inuvialuit Settlement Region (ISR) to develop a culturally appropriate metadata framework for a digital library of cultural resources. It will discuss gathering of data to inform the first iteration of the metadata framework and digital library prototype, as well as revisions made to both the framework and the digital library based on feedback obtained through community interaction with the prototype.     

ASSESSING CHEMISTRY-LEARNING COMPETENCIES OF STUDENTS IN ISOLATED RURAL SENIOR HIGH SCHOOLS BY USING THE NATIONAL EXAMINATION: A CASE STUDY OF SIMEULUE ISLAND,INDONESIA

This study explored learning competency based on the Indonesian National Examination focusing especially on chemistry performance and the circumstances of senior high school students and teachers in rural areas of Simeulue Island, Indonesia. The National Examination total score and chemistry score for students in rural areas were consistently lower than students in urban areas during 2008–2010. The majority of rural students were failing to master key chemistry concepts. Their low performance on laboratory-based questions appeared to indicate that the associated practical work was not done as part of the chemistry courses. Some chemistry topics were not taught due to insufficient time, student weaknesses, insufficient textbooks, and other reasons. The issues of low competency of teachers, poverty for the majority of students, low enrollment in schools, and low competition among students in these rural senior high schools appeared to be common problems across rural settings. The local government has recommended providing a consolidated rural high school with qualified chemistry teachers, laboratories, and transportation to address factors negatively influencing student achievement. Furthermore, local rural school officials need to recruit and retain qualified teachers in these isolated areas, provide effective textbooks and instructional resources, and facilitate the professional development of chemistry teachers.