Molecular game theory for a toxin-dominant food chain model

Animal toxins that are used to subdue prey and deter predators act as the key drivers in natural food chains and ecosystems. However, the predators of venomous animals may exploit feeding adaptation strategies to overcome toxins their prey produce. Much remains unknown about the genetic and molecular game process in the toxin-dominant food chain model. Here, we show an evolutionary strategy in different trophic levels of scorpion-eating amphibians, scorpions and insects, representing each predation relationship in habitats dominated by the paralytic toxins of scorpions. For scorpions preying on insects, we found that the scorpion α-toxins irreversibly activate the skeletal muscle sodium channel of their prey (insect, BgNa_V1) through a membrane delivery mechanism and an efficient binding with the Asp/Lys-Tyr motif of BgNa_V1. However, in the predatory game between frogs and scorpions, with a single point mutation (Lys to Glu) in this motif of the frog''s skeletal muscle sodium channel (fNa_V1.4), fNa_V1.4 breaks this interaction and diminishes muscular toxicity to the frog; thus, frogs can regularly prey on scorpions without showing paralysis. Interestingly, this molecular strategy also has been employed by some other scorpion-eating amphibians, especially anurans. In contrast to these amphibians, the Asp/Lys-Tyr motifs are structurally and functionally conserved in other animals that do not prey on scorpions. Together, our findings elucidate the protein-protein interacting mechanism of a toxin-dominant predator-prey system, implying the evolutionary game theory at a molecular level.     

Comparing Bachelor’s Degree Curricula at Three Groups of Colleges and Universities: Flexibility or Idiosyncrasy?*

Despite baccalaureates in criminal justice (BCJ) being among the most awarded degrees in this country, little published research has appeared in recent years on these programs or their curricula. Using 2015–2016 data collected from the population of BCJ-granting institutions (N = 670) in the U.S., we partially replicated Southerland’s 2002 Criminal justice curricula in the United States: A decade of Change and extended Sloan and Buchwalter’s 2016 The state of bachelor’s degree programs in the United States: Institutional, department, and curricula features analyses of BCJ curricula by comparing selected features of them across three groups of colleges/universities: public, private, not-for-profit, and private, for-profit. Results revealed significant differences existed in curricula by institutional locus of control, indicating a general lack of consensus on undergraduate curricula, including in such fundamental areas as total hours needed for the major. We discuss the implications of these results for the discipline, including revisiting accreditation as a mechanism for creating standardized curricula, and suggest further research on the status of undergraduate education to help insure the discipline offers the highest quality baccalaureate programs possible.     

Muscle recruitment patterns of the subscapularis,serratus anterior and other shoulder girdle muscles during isokinetic internal and external rotations

The aims of this study were to investigate the differences in peak muscle activity and recruitment patterns during high- and low-velocity, concentric and eccentric, internal and external isokinetic shoulder rotations. Electromyographic activity of the rotator cuff and eight superficial muscles of the shoulder girdle was recorded on 25 healthy adults during isokinetic internal and external shoulder rotation at 60°/s and 240°/s. Peak muscle activity, electromyographic envelopes and peak isokinetic moments were analyzed using three-factor ANOVA and statistical parametric mapping. The subscapularis and serratus anterior showed moderate to high peak activity levels during each conditions, while the middle and posterior deltoids, upper, middle and lower trapezius, infraspinatus and supraspinatus showed higher peak activity levels during external rotations (+36.5% of maximum voluntary activation (MVA)). The pectoralis major and latissimus dorsi were more active during internal rotations (+40% of MVA). Only middle trapezius and pectoralis major electromyographic activity decreased with increasing velocity. Peak muscle activity was similar or lower during eccentric contractions, although the peak isokinetic moment increased by 35% on average. The subscapularis and serratus anterior appear to be important stabilizers of the glenohumeral joint and scapula. Isokinetic eccentric training at high velocities may allow for faster recruitment of the shoulder girdle muscles, which could improve joint stability during shoulder internal and external rotations.     

Evolution of muscular fatigue in periscapular and rotator cuff muscles during isokinetic shoulder rotations

To this day, how shoulder muscles react to a strong fatigue stimulus during dynamic shoulder rotations remains unknown. The aims of this study were to assess the effect of repeated maximal internal-external isokinetic shoulder rotations on shoulder strength and muscle activity. Twenty-four individuals completed a 50-repetition fatiguing isokinetic protocol while electromyography was recorded on eleven muscles of the shoulder girdle. Time-frequency transformation and an ANOVA model using statistical parametric mapping methods were used to analyze shifts in instantaneous median frequency (MDF) between each 10-repetition Blocks. Peak torques decreased in both internal and external rotation (P < 0.01) by 24.8% on average which indicated the presence of fatigue. Significant decrease in MDF (P < 0.01) was observed for pectoralis, middle deltoid, upper, middle and lower trapezius, infraspinatus and subscapularis muscles. The observed fatigue to the periscapular and rotator cuff muscles suggests that shoulder stability could be compromised during repeated shoulder rotations, which could underlie the increased risk of scapular dyskinesis and shoulder impingement during fatiguing tasks. The present study provides a deeper understanding on the manifestations of fatigue within muscles of the shoulder girdle and the results could be applied toward improvements in athlete shoulder injury prevention and rehabilitation programs.     

‘War and Peace’ at the 1980 Moscow and 2014 Sochi Olympics: The Role of Hard and Soft Power in Russian Identity

Abstract

Russia’s (and the USSR’s) use of sports mega-events (SMEs) makes this BRICS country (Brazil, Russia, India, China, and South Africa) not only an outlier among emerging states, but also among key SME hosts generally. Both the historic Moscow Olympics (1980) and the more recent hosting of the 2014 Sochi Winter Olympics provide evidence that Russia has, on both occasions, focussed on geopolitical priorities using hard power (military might) at the expense of soft power acquisition. Furthermore, both Olympics were, first and foremost, used to pursue domestic soft power goals. This, again, makes Russia an outlier in terms of the political use of SMEs by states in the literature on this subject. The 1980 Olympic Games, therefore, in terms of their potential to generate soft power and national unity, turned out to be a mis-used opportunity for Russia. To what extent is this specific to Russia and could the first Russian Olympics provide valuable insight into the modern-day hosting of SMEs by Russia (2014/2018)?     

Experimental validation of dynamic stability analysis applied to dart flight

The game of darts attracts a large international following and can be fiercely competitive. Despite its popularity, and the large equipment market, no previous peer-reviewed studies have examined the trajectory of a dart in flight. This study used high-speed video techniques to measure the trajectories of 225 dart throws from 19 amateur players. The dart’s pitch and angle of attack were found to oscillate during flight in a manner that is analogous to damped harmonic motion. It was also found that the dart’s oscillation frequency was strongly correlated to launch speed, whilst its characteristic wavelength and damping ratio were independent of launch speed. The measured wavelength of oscillation (2.16 m) was found to be similar to the regulation throwing distance (2.37 m). It is proposed that the dart is ‘tuned’ to the throwing distance such that it undergoes one full oscillation before striking the board. The dart flight was modelled using a classical dynamic stability analysis and good agreement was found between the experimental observations and the theoretical predictions. The success of the model confirms that the approach can be used to explore the dynamics of different dart designs through parametric sensitivity analyses.     

‘Yes we are inclusive’: Examining provision for young people with disabilities in community sport clubs

The last two decades within Australia have witnessed a range of policies and strategies seeking to promote the inclusion of young people with disabilities within mainstream community sport clubs. Whilst research at an institutional level has highlighted the problems with mainstreaming agendas, few studies have examined how grassroots clubs, as key components of the supply side of inclusive provision seek to respond to such policy imperatives. In this paper, therefore, the authors provide a critical analysis of the ways in which clubs engage with inclusion policies in practice. Theoretically, the authors draw on the concept of policy enactment and educational inclusivity. Through analysis of semi-structured interviews with club volunteers, the findings illustrate three key areas. Firstly, the importance of individual volunteers in establishing and developing provision within clubs; secondly, the largely separatist nature of disability provision within clubs; and thirdly, that policies tend to encourage club to focus on narrow forms of participation that lead to competitive pathways and mirror the structure of mainstream sport. In the conclusion, the authors problematize the notion of inclusion presented in policy and practice, suggesting such imperatives do not encourage a holistic approach.     

A novel method for the performance of isometric exercise in the home

There is a paucity of research on devices suitable for home-based isometric exercise. Our aim was to compare cardiovascular responses to isometric exercise using novel and established methods. Ten individuals (age 34.0 +/- 8.5 years, mass 68.2 +/- 10.4 kg, height 1.72 +/- 0.09 m; mean +/- s) performed three different isometric exercise protocols with 48 h between each. Each protocol involved four repeated exercise bouts of 2 min at 30% maximum voluntary contraction force using alternate legs (transducer), alternate arms (transducer), or alternate arms (novel device). Systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and heart rate were measured every 30 s. The highest (peak) values during each 2 min bout of exercise were recorded (peak systolic blood pressure, peak diastolic blood pressure, peak mean arterial blood pressure and peak heart rate). At the end of each 2 min exercise bout, the participants rated their perceived discomfort using Borg's CR-10 scale. There was a statistically significant difference in peak systolic blood pressure between isometric arm flexion using the force transducer and the novel device [158.1 +/- 10.8 vs. 149.1 +/- 13.9 mmHg (mean +/- s); P = 0.02]. Further analysis showed that peak systolic blood pressure was on average 9 mmHg higher using the force transducer with limits of agreement of - 15.97 to 33.97 mmHg. Analysis of the peak diastolic blood pressure, peak mean arterial blood pressure, peak heart rate and CR-10 data revealed no statistically significant differences between the three protocols. These results suggest that this novel, home-based method elicited similar cardiovascular responses during isometric exercise to those of established laboratory-based methods. However, the lower peak systolic blood pressure using the modified scales warrants further investigation before this method is used widely in the home.     

Evidence‐based librarianship: what might we expect in the years ahead?*

Objective: To predict the possible accomplishments of the Evidence‐Based Librarianship (EBL) movement by the years 2005, 2010, 2015 and 2020. Methods: Predictive. The author draws upon recent events, relevant historical events and anecdotal accounts to detect evidence of predictable trends. Results: The author develops a set of probable predictions for the development of EBL. Although incomplete evidence exists, some trends still seem discernible. Conclusion: By 2020, EBL will have become indistinguishable from mainstream health sciences librarianship/informatics practices.