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991.
Yogita S. Raut Uma S. Bhartiya Purushottam Kand Rohini W. Hawaldar Ramesh V. Asopa Lebana J. Joseph MGR Rajan 《Indian journal of clinical biochemistry : IJCB》2016,31(1):99-103
The aim was to study the genotoxic effect of high concentration of thyroxine (T4) in vivo in peripheral blood lymphocytes (PBL) of the patients suffering from thyroid disorders. The effect was compared by performing in vitro experiments with addition of increasing concentration of T4 (0.125–1 µM) in whole blood samples from healthy donors. Cytokinesis-blocked micronuclei (CBMN) assay method was used to assess the DNA damage in the PBL. The study included 104 patients which were grouped as control (n = 49), hyperthyroid (n = 31) and hypothyroid (n = 24). A significant increase in micronuclei (MN) frequency was observed in hyperthyroid patients when compared with the hypothyroid and euthyroid group thereby suggesting increased genotoxicity in hyperthyroidism (p < 0.001). A significant increase in MN frequency was observed at T4 concentration of 0.5 µM and above when compared to lower T4 concentrations (0.125 and 0.25 µM) and basal in in vitro experiments (p = 0.000). The results indicate that the T4 in normal concentration does not exhibit the genotoxic effect, as observed in both the in vivo and in vitro experiments. The toxicity of T4 increases at and above 0.5 μM concentration in vitro. Therefore acute T4 overdose should be handled promptly and effectively so as to avoid the possible genotoxic effect of high concentration of T4 in vivo. 相似文献
992.
Salivary β-glucuronidase activity was studied in 20 healthy subjects without habits and 10 with habits, 38 untreated patients
of advanced head and neck cancer and 21 patients after treatment either after surgery or radiation.
Salivary β-glucuronidase activity was elevated in untreated cases of head and neck cancer (p<0.001), with a fall in the activity
after treatment. The post operative fall in the activity of salivary β-glucuronidase activity was highly significant (p<0.001)
as compared to post radiation. This test can be utilized in the diagnosis and also for monitoring the course of the disease. 相似文献
993.
Current citation-based document retrieval systems generally offer only limited search facilities, such as author search. In order to facilitate more advanced search functions, we have developed a significantly improved system that employs two novel techniques: Context-based Cluster Analysis (CCA) and Context-based Ontology Generation frAmework (COGA). CCA aims to extract relevant information from clusters originally obtained from disparate clustering methods by building relationships between them. The built relationships are then represented as formal context using the Formal Concept Analysis (FCA) technique. COGA aims to generate ontology from clusters relationship built by CCA. By combining these two techniques, we are able to perform ontology learning from a citation database using clustering results. We have implemented the improved system and have demonstrated its use for finding research domain expertise. We have also conducted performance evaluation on the system and the results are encouraging. 相似文献
994.
995.
Bhawana Nigam S. P. Joshi Seema Nagar Rajesh Chavan D. Pendharkar 《Indian journal of clinical biochemistry : IJCB》1996,11(2):124-128
The analysis of biochemical parameters in 162 patients with various neoplastic disorders along with 50 normal subjects showed significant rise in serum alkaline phosphatase and lactate dehydrogenase as compared to normal subjects. 21 patients with other monoclonal gammopathies which include infection and immunological diseases were also studied. Parameters such as serum calcium, uric acid, total protein, albumin and globulin were also analyzed in 42 (26%) cases of multiple myeloma, 27 (17%) cases of gastro-intestinal malignancies, 22 (14%) cases of urogenital malignancies, 11 (6%) cases of carcinoma breast, 4 (2%) cases of bone tumors, 21 (12%) cases of other monoclonal gammopathies, including 7 (4%) cases of infection and 14 (8%) cases of immunological diseases. The results indicate use of enzymes alkaline phosphatase and lactate dehydrogenase in neoplastic disorders. 相似文献
996.
S. Kaushik S. S. Trivedi A. Jain J. Bhattacharjee 《Indian journal of clinical biochemistry : IJCB》2002,17(2):68-73
Colostrum, the mammary secretion during first 2–4 days of lactation, provides all the essential components of nutrition and
passive immunity required by the newborn. Pregnancy induced hypertension (PIH), glucose intolerance and anaemia are common
medical complications observed during pregnancy in Indian women and their effects were studied on the composition of colostrum
collected within 24 hours of delivery from lactating women included in the study. PIH during pregnancy significantly decreased
colostrum IgA and total proteins, but showed a significant increase in K+ levels, where as women with glucose intolerance showed a significant decrease in total lipids and lactose and an increase
in Na+ levels in colostrum compared to normal controls. The group with anaemia also showed a significant decrease in colostrum IgA
and total protein levels when compared with the control group. Awareness about the changes that occur in the composition of
colostrum during complicated pregnancies can be an important and useful tool for preventive and protective paediatrics. 相似文献
997.
Savita Singh Varun Malhotra K. P. Singh S. B. Sharma S. V. Madhu O. P. Tandon 《Indian journal of clinical biochemistry : IJCB》2001,16(2):216-220
Nineteen subjects of non-insulin dependent diabetes mellitus (NIDDM) between the age group of 30–60 yrs were studied to see
the effect of specific yoga asanas on fasting and postprandial blood glucose (FBG, PPG), serum malondialdehyde (MDA) and glycosylated
hemoglobin (HbA1) in addition to drug treatment and diet control. The duration of diabetes ranged from 1–10 years. Patients with renal, cardiac
and proliferative retinal diseases were excluded from the study. The same patients served as their own control. Subjects were
called in the morning to the cardio-respiratory laboratory and were given training by a yoga expert. Yoga asanas included
Suryanamskar, Tadasan, TriKonasan, Padmasan, Pranayam, Paschimottanasan, Ardhmatsyendrasan, Pavanmukthasan, Sarpasan and Shavasan.
The asanas were done every day for 40 days for 30–40 min. FBG, PPG, serum MDA and HbA1 were estimated before and after 40 days of yoga asanas regimen. Significant reduction was seen in FBG from 220 mg/dl to 162
mg/dl, PPG from 311 mg/dl to 255 mg/dl, MDA from 6 nmol/l to 3 nmol/l and HbA1, from 8.8% to 6.4%. Subjects felt better and were relieved of their stresses and had an improvement in their day to day performance.
The decrease was statistically significant (p<0.0001 for FBG and PPG, p<0.001 for MDA and for HbA1). 相似文献
998.
999.
1000.
Michael J. Kurtz Guenther Eichhorn Alberto Accomazzi Carolyn Grant Markus Demleitner Edwin Henneken Stephen S. Murray 《Information processing & management》2005,41(6):1395-1402
It has been shown (Lawrence, S. (2001). Online or invisible? Nature, 411, 521) that journal articles which have been posted without charge on the internet are more heavily cited than those which have not been. Using data from the NASA Astrophysics Data System (ads.harvard.edu) and from the ArXiv e-print archive at Cornell University (arXiv.org) we examine the causes of this effect. 相似文献