Effects of vanadate supplementation on high fat-diet and diabetes-induced metabolic changes in liver

Normal and streptozotocin-induced diabetic rats were fed the control high starch-diet or a high fatdiet supplemented with or without sodium orthovanadate (1.5 mg/g diet) for six weeks. Plasma glucose, insulin and triacylglycerol levels and the activities of hepatic glycogen synthase, phosphorylase, glucose-6-phosphate dehydrogenase, malic enzyme, and ATP-citrate lyase were measured in these eight groups of rats. The high fat-diet increased the levels of insulin (P<0.05) and triacylglycerol (P<0.01) in plasma and decreased the activities (P<0.001) of phosphorylase (active from and total) and the lipogenic enzymes. Vanadate supplementation led to significant (P<0.001) decreases in the elevated insulin and triacylglycerol levels whereas the enzyme activities remained unaffected. Diabetes and fat diet in combination caused 3.7-fold increases in plasma glucose and triacylglycerol levels and vanadate decreased them by 58% and 74% respectively. Vanadate improved the activities of hepatic glycogen metabolizing and lipogenic enzymes in diabetic rats when they were fed on control starch-diet but not with high fat-diet. This study shows that vanadate normalizes hyperinsulinemia and hypertriglyceridemia but not the defective hepatic glycogen metabolism in high fat-fed rats.     

Raised serum homocysteine levels in patients of coronary artery disease and the effect of vitamin B12 and folate on its concentration

Homocysteine(Hcy) has been implicated as a novel risk factor of Coronary Artery Disease (CAD) among Asian Indians, but many studies done in India failed to reveal any direct correlation. It has also been reported that Folic acid and Vitamin B12 levels inversely affect serum levels of homocysteine. In this study, we looked at the levels of homocysteine among patients with CAD. The effect of Vitamin B12, Folate and other risk factors on homocysteine levels were also evaluated. Mean homocysteine levels in cases (22.81±13.9, n=70) were significantly higher (p=<0.001) than the controls (7.77±7.3, n=70). However no statistically significant correlation could be deduced between homocysteine Vitamin B12, and Folate. Cumulative analysis have indicated an increase in homocysteine levels among patients with CAD with every additional risk factor.     

Factor structure evidence for developmental levels of perceptual processing on the developmental test of visual-motor integration

Beery's Developmental Test of Visual-Motor Integration was individually administered to 193 school-age children. Test protocols were factor analyzed by a principal component solution. Four factors were obtained, indicating that the test does not measure a unitary dimension of perceptual-motor development, but rather four distinct levels or stages for the age range of children investigated. The structural features of the designs that make up the test were used to define the factors. It is argued that a more useful interpretation of performance on this test would be one that designates visualmotor processing in terms of levels, not age equivalents.     

Assessing the acceptability of behavioral interventions used in classrooms

This study examined components of teacher judgements that an intervention is either acceptable or unacceptable. A total of 180 preservice and student teachers were asked to evaluate the acceptability of six different interventions. The evaluations of acceptability were assessed using a 20–item rating scale. A factor analysis of the rating scale yielded one major dimension, a general acceptability factor, and four secondary dimensions of intervention acceptability: risk to the target child, amount of teacher time required, effects of the intervention on other children, and amount of teacher skill required. Results are discussed in terms of designing interventions that are both effective and usable by classroom teachers.     

Teachers in regular classrooms: An applied setting for successful behavior programming

An operant-based program was established to study the effectiveness of regular classroom teachers as mediators for behavior change in regular classroom settings. Fifty-nine first and second graders were matched on several measures and randomly assigned to an experimental condition or a control condition. Experimental children were addressed through teacher-generatedlconsultant-supported behavior intervention strategies. Changes in behavior were examined by assessing differences from initial baseline and from first to second administration of the Child Behavior Checklist. In- class behavior change was significantly greater for the experimental condition than for the control condition, although behavior change from first to second administration of the Child Behavior Checklist was significant for all groups. A moderate to high rate of compliance to the intervention program was maintained by teachers, and moderate to high ratings of satisfaction were obtained for the program from all participants. The effectiveness, feasibility, and applicability of the program are discussed.     

Creating information resources and trainings for farmworker-serving community health workers

Background:Farmworker-serving community health workers have limited access to farmworker health research findings, training, and education resources. With funding from the National Library of Medicine, we are working to improve the health information literacy of both community health workers and farmworkers. We conducted focus group discussions with community health workers to explore their experiences providing health education and information to farmworkers, their information-seeking behaviors, and their technology and information needs. Data from the focus groups provided insights into the main areas in which community health workers would like to receive professional development.Case Presentation:Our team, which includes health sciences librarians, developed a resource list of educational materials for farmworker health, videos to increase community health workers'' skills finding health information online, and webinars to introduce these resources to community health workers. Videos, available in Spanish and English, included instruction on finding and evaluating online health information, accessing reputable online consumer health information sources, and advanced searching tips for Google and PubMed. Through three webinars, we introduced the resource list, videos, and design software for creating handouts and infographics to community health workers.Conclusions:Community health workers have a critical role in providing health education and information to farmworkers, and our efforts represent a first step in addressing community health workers'' limited access to professional development. Health sciences librarians are well positioned to partner with interdisciplinary teams working to reduce health disparities and provide resources and training to community health workers, farmworkers, and other underserved communities.     

White Fatigue: Naming the Challenge in Moving from an Individual to a Systemic Understanding of Racism

This article introduces the notion White fatigue. White fatigue occurs for White students who have grown tired of learning and discussing race and racism, despite an understanding of the moral imperative of anti-racist and anti-oppressive practices. The article differentiates White fatigue from ideas like White resistance, White guilt, or White fragility, arguing that each of these phenomenon occur at different stages of White Racial Identity Development. Distinction is also drawn among White fatigue and other forms of racially based fatigue, specifically racial battle fatigue and White people fatigue syndrome. Further drawing on the notion of stereotype threat, the article considers the challenges for White students learning about race and racism while simultaneously resisting being labeled a racist. This struggle is elemental to the manifestation of White fatigue. Ultimately, the author argues that educators must be more accurate in how they define the range of responses from White students, consistently humanize all students in the process of understanding race and racism, and encourage further research for understanding a condition that is happening to a growing number of students.