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Endothelialization is of great significance for vascular remodeling, as well as for the success of implanted vascular grafts/stents in cardiovascular disease treatment. However, desirable endothelialization on synthetic biomaterials remains greatly challenging owing to extreme difficulty in offering dynamic guidance on endothelial cell (EC) functions resembling the native extracellular matrix-mediated effects. Here, we demonstrate a bilayer platform with near-infrared-triggered transformable topographies, which can alter the geometries and functions of human ECs by tunable topographical cues in a remote-controlled manner, yet cause no damage to the cell viability. The migration and the adhesion/spreading of human ECs are respectively promoted by the temporary anisotropic and permanent isotropic topographies of the platform in turn, which appropriately meet the requirements of stage-specific EC manipulation for endothelialization. In addition to the potential of promoting the development of a new generation of vascular grafts/stents enabling rapid endothelialization, this stage-specific cell-manipulation platform also holds promise in various biomedical fields, since the needs for stepwise control over different cell functions are common in wound healing and various tissue-regeneration processes. 相似文献
74.
Luiz Rodrigo Augustemak de Lima Isabela de Carlos Back Everson Araújo Nunes Diego Augusto Santos Silva Edio Luiz Petroski 《Journal of sports sciences》2019,37(1):50-58
This study aimed to investigate if moderate to vigorous physical activity (MVPA) and aerobic fitness are associated with cardiovascular risk factors in HIV+ children and adolescents. Sixty-five children and adolescents (8 to 15 years) provided minutes of MVPA measured by accelerometers and peak oxygen uptake (peak VO2) by breath-by-breath respiratory exchange. Cardiovascular risk factors were characterized by body fat, blood pressure, total cholesterol, HDL-c, LDL-c, triglycerides, glucose, insulin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α) and carotid intima-media thickness. Results indicated that higher MVPA was associated with lower values of total (β = ?3.566) and trunk body fat (β = ?3.495), total cholesterol (β = ?0.112) and LDL-c (β = ?0.830). Likewise, higher peak VO2 was associated with lower total (β = ?0.629) and trunk body fat values (β = ?0.592) and levels of CRP (β = ?0.059). The physically active participants had lower total cholesterol (?24.4 mg.dL?1) and LDL-c (?20.1 mg.dL?1) compared to participants judged to be insufficiently active. Moreover, participants with satisfactory peak VO? showed lower total (?4.1%) and trunk (?4.3%) body fat, CRP (?2.3 mg.L?1), IL-6 (?2.4 pg.mL?1) and TNF-α (?1.0 pg.mL?1) compared to low peak VO2 peers. High levels of MVPA and aerobic fitness may prevent developing of cardiovascular risk factors in children and adolescents HIV+. 相似文献
75.
Taís Rieping Guilherme Eustáquio Furtado Matheus Uba Chupel Juan C. Colado Eef Hogervorst 《Research quarterly for exercise and sport》2019,90(1):36-45
Purpose: The aim of this study was to test the effects of chair-based exercise programs on salivary stress hormones, physical fitness, and functional autonomy of institutionalized older women. Method: In total, 47 participants (80 ± 8.04 years old) were recruited and allocated into three groups: chair-based aerobic exercises (CAE, n = 19), chair-based elastic-band strength exercises (CSE, n = 15), and a control group (CG, n = 13). A 14-week exercise intervention was done for the CAE and CSE groups, two times per week, in no consecutive days. Members of the CG did not participate in any type of exercise but kept their regular lifestyle. Fear of falling, autonomy, physical fitness, salivary cortisol, and alpha-amylase levels were assessed before and after the intervention. Results: The CAE group improved upper and lower body strength, agility–dynamic balance, and autonomy, with fear of falling decreasing significantly (p < .05, moderate effect size). Both exercise groups showed a trend toward an increase in salivary alpha-amylase levels (CAE = 43%, d = .31, and CSE = 44%, d = .41). Conclusion: Both exercise programs were able to improve functional autonomy, even in elders older than 80 years of age. It might be interesting to investigate the effectiveness of combining both aerobic and strength exercises in a unique protocol. The modulation effect of exercise in the hormonal responses needs to be further explored. 相似文献
76.
Juan Antonio Simón 《Soccer & Society》2019,20(7-8):948-959
ABSTRACTOne of the most memorable moments in the World Cups history is Marco Tardelli’s second goal in Italy’s win over Germany in the 1982 World Cup finals. Better known as Tardelli’s scream, it is thus a perfect object to analyse in order to understand football’s deeper social meanings and its political and cultural undertones, in this case both for the World Cup champions, Italy, and for the host country, Spain. In the Spanish case, organizing the World Cup was a huge political opportunity for the just restored democracy to showcase to the world a modern and pluralistic society leaving behind the authoritarian and outdated dictatorship. As for Italy, their first World Cup winning since World War II was heavily politically used by actors across the political spectrum. Such nationalistic approach constituted a novelty after decades of a low profile national discourse. 相似文献
77.
Alejandro Torrejón Carlos Balsalobre-Fernández G. Gregory Haff 《Sports biomechanics / International Society of Biomechanics in Sports》2019,18(3):245-255
This study aimed to determine the suitability of the load-velocity relationship to prescribe the relative load (%1RM) in women, as well as to compare the load-velocity profile between sexes and participants with different strength levels. The load-velocity relationship of 14 men (1RM: 1.17 ± 0.19) and 14 women (1RM: 0.66 ± 0.13) were evaluated in the bench press exercise. The main findings revealed that: (I) the load-velocity relationship was always strong and linear (R2 range: 0.987–0.993), (II) a steeper load-velocity profile was observed in men compared to women (Effect size [ES]: 1.09), with men showing higher velocities for light loads (ES: ? 0.81 and ? 0.40 for the y-intercept and 30%1RM, respectively), but women reporting higher velocities for the heavy loads (ES: 1.14 and 1.50 at 90%1RM and 100%1RM, respectively); and (III) while the slope of the load-velocity profile was moderately steeper for weak men compared to their strong counterpart (ES: 1.02), small differences were observed between strong and weak women (ES: ? 0.39). While these results support the use of the individual load-velocity relationship to prescribe the %1RM in the bench press exercise for women, they also highlight the large disparities in their load-velocity profile compared to men. 相似文献
78.
通过对湖南中医药大学非英语专业学生的两篇习作的研究表明:在纠正学生写作中所犯的逻辑错误方面,相比教师反馈,同级反馈效度低。因此,教师在对学生习作进行反馈时,尤其要指出学生逻辑思维方面的漏洞,以提高他们的逻辑思维能力,从而从根本上提高学生的写作应用能力。 相似文献
79.
在闽粤赣交界的闽西山区,有着让世界为之震撼的“独一无二的神话般的山区建筑”,它们便是客家土楼。这是一种集体聚居的生土夯筑的大型建筑,形式多样,且因地制宜,与周围山水和谐相处。2008年7月7日,第32届世界遗产大会正式将“福建土楼”列入《世界遗产名录》,成为中国第36个世界遗产地! 相似文献
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