前列腺癌:亟待肿瘤标志物和治疗新靶点(英文)

研究目的:这篇综述系统地阐述了前列腺癌的发生、发展、相关分子信号通路以及分子标志物用于前列腺癌的临床诊断和前列腺癌诊治所面临的挑战。重要结论:许多分子信号通路通过影响细胞生长、凋亡、血管生成等病理生理过程而参与了前列腺癌的起始、发生和发展。这些研究基础有助于寻找前列腺癌的肿瘤标志物和改进前列腺癌的治疗。虽然去势治疗是早期前列腺癌治疗的金标准,但是晚期的激素抵抗型前列腺癌(CRPC)的治疗仍面临着巨大的挑战。所幸的是,目前研究发现可以通过切断特异的蛋白-蛋白相互作用或者通过调节某些影响肿瘤生长和转移的关键分子来治疗前列腺癌,能减少传统治疗所带来的副作用;相关临床研究已开始实施。这些研究进展给前列腺癌的诊治带来了新的曙光。     

The development and application of a specialised word list: the case of Fabrication

Learners in the trades are faced with learning a large amount of technical vocabulary along with the content of their field, but they do not tend to encounter this language outside their courses of study. This technical vocabulary is a core element in their developing knowledge of their trade and their learner identity. This article focuses first on identifying technical vocabulary in Fabrication using specialised written and spoken corpora, and through extensive checking with experts in the field as well as reference sources. A technical word list of 1079 types was developed, along with a list of common abbreviations and their meanings and a list of proper nouns. The technical word list covers over 30% of the vocabulary in the written Fabrication corpus and just over 9% of the spoken Fabrication corpus. The second part of the article discusses this vocabulary in light of the concept of vocational thresholds and provides suggestions for incorporating the word list into pedagogy, including an apprenticeship approach in which a focus on literacy/literacy acquisition is embedded into content teaching. Suggestions for future research are also included.     

Disseminating development initiatives in British higher education: a case study

The Effective Teaching and Assessment Programme (ETAP) was commissioned and funded by the Higher Education Funding Councils for England, Scotland and Wales and ran during the academic year 1993–4. Its aim was to identify and disseminate best practice in specific subject areas, student support and resource based learning. ETAP supported five projects, each undertaken by a consortium of British higher education institutions. This paper reports an evaluation of the programme based on interviews with leaders of the individual projects, along with a questionnaire survey of potential users of the products of the programme. A framework is offered for interpreting the results of the evaluation. Six different meanings of the word dissemination are identified, corresponding to the different degrees to which users actively engage with the materials produced. These distinctions are applied to the data collected and the findings are summarised in terms of the key notions of awareness of what is available, the attitude of teaching staff towards centrally-produced materials, and the accessibility of those materials. The implications of these three concepts are discussed in relation to the technical, organisational and presentational issues which promote or hinder the effectiveness of the dissemination. A number of policy recommendations for Funding Councils and institutions are outlined.     

Expression and Reception: An Analytic Method for Assessing Message Production and Consumption in CMC

This article presents an innovative methodology to study computer-mediated communication (CMC), which allows analysis of the multi-layered effects of online expression and reception. The methodology is demonstrated by combining the following three data sets collected from a widely tested eHealth system, the Comprehensive Health Enhancement Support System (CHESS): (1) a flexible and precise computer-aided content analysis; (2) a record of individual message posting and reading; and (3) longitudinal survey data. Further, this article discusses how the resulting data can be applied to online social network analysis and demonstrates how to construct two distinct types of online social networks—open and targeted communication networks—for different types of content embedded in social networks.     

Examining public acquisition of science knowledge from social media in Singapore: an extension of the cognitive mediation model

This study extends the cognitive mediation model (CMM) by examining the role of social media in cultivating public science knowledge. A sample of 901 Singaporeans was collected through an online survey panel. The results showed that the CMM could be applied to a social media context with a focus on science literacy. Specifically, the findings indicated that people with higher levels of surveillance gratification and social utility motivations tended to pay more attention and to elaborate more about science news that they encounter on social media. Likewise, people with greater social utility motivation tended to engage in greater interpersonal discussions on social media. Notably, attention to news on social media had an indirect association with science knowledge through news elaboration and interpersonal discussion on social media. Implications for theory and practice for science communication were discussed.     

Selected characteristics,roles, goals,and satisfactions of department chairmen in state and land-grant institutions

Chairmen at 38 state and land-grant institutions were found to be involved in three major roles: academic, administrative, and leadership. The academic role consists of duties of student involvement and research activities. Chairmen enjoy this role and report high emphasis on concurrent goals but feel frustrated in terms of time to pursue commensurate activities. The administrative role requires the majority of time and also contains some of the less desirable duties. In addition, administrative goals are seen as over-emphasized. The leadership role involves tasks related to academic personnel and program development. It is a major satisfaction realized by accepting the position of chairman. Developing abilities of faculty members and maintaining academic freedom are the two most important goals in this role. The respondents also made suggestions on changes and development programs which would improve their effectiveness.     

Five Critical Stances Towards Liberal Philosophy of Education in Britain

In this paper John White argues that there has been a decline in interest in and support for liberalism in British philosophy of education. He provides examples of work by leading figures in the field that demonstrates scepticism about the key liberal value of autonomy and offers an analysis of new influences in the field that have contributed to this decline. In particular he notes the increase of work from a religious perspective. Doubts are expressed about the practical relevance to education of some of these avenues of thought, and the suggestion is made that they cause those within the field to be more out of touch with society at large, in which liberal values have continued to be the major source of animation. The paper is followed by short responses from four philosophers of education whose work he criticises.     

Special Education in American Charter Schools: State level policy,practices and tensions

The US charter school movement is based upon the supposition that granting individual public schools increased autonomy from state and district rules and regulations in exchange for more accountability will foster the creation of innovative, effective and efficient schools. However, while state charter school laws free these schools from various state and district rules and regulations, the schools must still operate within the civil rights parameters legislated by federal statutes. Of particular import are federal laws that guarantee that children with disabilities receive a free appropriate public education. Project SEARCH, a 3 year qualitative study of special education in US charter schools revealed that there is a fundamental philosophical gap between the individualised, autonomous nature of charter schools and the highly regulated nature of special education. The philosophical gap is complicated by some charter schools' inability to amass the fiscal and human capacity needed to meet the needs of individual children with disabilities.