The effects of laser welding on heterogeneous immunoassay performance in a microfluidic cartridge

Sealing of a microfluidic cartridge is a challenge, because the cartridge commonly contains heat-sensitive biomolecules that must also be protected from contamination. In addition, the objective is usually to obtain a sealing method suitable for mass production. Laser welding is a rapid technique that can be accomplished with low unit costs. Even though the technique has been widely adopted in industry, the literature on its use in microfluidic applications is not large. This paper is the first to report the effects of laser welding on the performance of the heterogeneous immunoassay in a polystyrene microfluidic cartridge in which biomolecules are immobilized into the reaction surface of the cartridge before sealing. The paper compares the immunoassay performance of microfluidic cartridges that are sealed either with an adhesive tape or by use of laser transmission welding. The model analyte used is thyroid stimulating hormone (TSH). The results show that the concentration curves in the laser-welded cartridges are very close to the curves in the taped cartridges. This indicates, first, that laser welding does not cause any significant reduction in immunoassay performance, and second, that the polystyrene cover does not have significant effect on the signal levels. Interestingly, the coefficients of variance between parallel samples were lower in the laser-welded cartridges than in the taped cartridges.     

The influence of performance-based management on teaching and research performance of Finnish senior academics

Despite the widespread use of performance-based management in higher education, empirical research on its actual impact has remained scarce, particularly in Europe. With agency theory as a framework, our study utilised survey data collected from Finnish universities in order to explore the influence of performance management on perceived teaching and research performance of senior academics. Our findings suggest that, although academics hold a quite positive view of performance measurement as such, this attitude does not correlate with perceived high performance in either teaching or research. Moreover, our results suggest that perceived high performance among academics still relates primarily to acknowledgement from the academic community and academic achievement rather than to measurement and financial incentives.     

Spatio-temporal processes of knowledge creation

This article presents a novel spatio-temporal framework for studying knowledge creation. To achieve this, we analyzed the recent literature on space, time and knowledge and conducted an empirical study. The intensive case was about four international distinguished university research groups in Finland in the fields of technology and science. Object, communicative and cognitive spaces with linear and relational times were used as tools for empirical analysis. Combinations of space and time bring out different aspects of knowledge. Knowledge processes of progressing knowledge (time-space), creating distinguished knowledge (space-time), and path-taking and bundling knowledge (spacetime) bind spaces and times closely together. Besides academy, the spatio-temporal framework can be applied to study the knowledge creation processes in art, business and local communities, for example.     

Is Education Getting Lost in University Mergers?

Mergers are common phenomena in higher education institutions. Improving educational quality is typically one of the stated goals of university mergers. Yet, little information exists about how merging institutions approach this goal. This paper presents results from a study of planning documents created prior to four mergers in the Finnish higher education system. These documents show that there was little concrete attention given to the educational issues related to the mergers. Most attention was placed on administrative issues and issues related to research. When educational issues were mentioned, it was almost always in the form of vague goals with few details provided about how the goals were to be reached. We conclude that this lack of attention to the educational aspect of mergers is a significant weakness of the planning process in these mergers.

     

Two discourses: Researchers and policy-making in higher education

The theme of this article focuses on how policy discourse and research discourse meet in contract research in higher education. The interplay of these discourses has consequences for researchers who have to balance conflicting demands, which we view as links between research and policy cycles. Two evaluation studies on the introduction and effects of new policy instruments are discussed, focusing on the interaction between policy needs, and research design. The examples are taken from policies in the development towards increasing self-regulation in higher education, of which Finland and the Netherlands are interesting examples in the European context.     

Effect of time-of-day-specific strength training on maximum strength and EMG activity of the leg extensors in men

In this study, we examined the effects of time-of-day-specific strength training on maximum strength and electromyography (EMG) of the knee extensors in men. After a 10-week preparatory training period (training times 17:00-19:00 h), 27 participants were randomized into a morning (07:00-09:00 h, n = 14) and an evening group (17:00-19.00 h, n = 13). Both groups then underwent 10 weeks of time-of-day-specific training. A matched control group (n = 7) completed all testing but did not train. Unilateral isometric knee extension peak torque (MVC) and one-repetition maximum half-squat were assessed before and after the preparatory training and after the time-of-day-specific training at times that were not training-specific (between 09:00 and 16:00 h). During training-specific hours, peak torque and EMG during MVC and submaximum isometric contraction at 40% MVC were assessed before and after the time-of-day-specific training. The main finding was that a significant diurnal difference (P < 0.01) in peak torque between the 07:00 and 17:00 h tests decreased after time-of-day-specific training in the morning group but not in the evening or control groups. However, the extent of this time-of-day-specific adaptation varied between individuals. Electromyography during MVC did not show any time-of-day-specific adaptation, suggesting that peripheral rather than neural adaptations are the main source of temporal specificity in strength training.     

Changes in performance and poling kinetics during cross-country sprint skiing competition using the double-poling technique

In this study, changes in skiing performance and poling kinetics during a simulated cross-country sprint skiing competition were investigated. Twelve elite male cross-country skiers performed simulated sprint competition (4 × 1,150 m heat with 20 min recovery between the heats) using the double-poling technique. Vertical and horizontal pole forces and cycle characteristics were measured using a force plate system (20-m long) during the starting spurt, racing speed, and finishing spurt of each heat. Moreover, heat and 20-m phase velocities were determined. Vertical and horizontal pole impulses as well as mean cycle length were calculated. The velocities of heats decreased by 2.7 ± 1.7% (p = 0.003) over the simulated competition. The 20-m spurting velocity decreased by 16 ± 5% (p < 0.002) and poling time increased by 18 ± 9% (p < 0.003) in spurt phases within heats. Vertical and horizontal poling impulses did not change significantly during the simulation; however, the mean forces decreased (p < 0.039) (vertical by 24 ± 11% and horizontal by 20 ± 10%) within heats but not between the heats. Decreased heat velocities over the simulated sprint and spurting velocities within heats indicated fatigue among the skiers. Fatigue was also manifested by decreased pole force production and increased poling time.     

School neighbourhood socio-economic status and teachers’ work commitment in Finland: longitudinal survey with register linkage

The extent to which school neighbourhood affects teachers’ work commitment is poorly known. In the current study, we investigated whether school neighbourhood socio-economic characteristics predicted teachers’ organizational and professional commitment. Primary school teachers (n?=?1042) responded to surveys in 2000–2001 (baseline) and 2004 (follow-up). Their responses were linked to records of the school neighbourhood income and unemployment levels obtained from nationwide registers. Teachers working in areas with a high income level and low unemployment rate had longer job tenure and higher probability of organizational (school) commitment at follow-up compared to teachers working in areas with a low income level or high unemployment rate. Less consistent associations were found for professional commitment. These findings suggest that school neighbourhood characteristics may affect teachers’ work commitment, especially their organizational commitment. Further research is needed to determine whether this increases inequalities in children’s learning opportunities.     

Pedagogical perspectives on the relationships between higher education and working life

The relationship between higher educationinstitutions and their environment has changedmarkedly during the last two decades.Massification and diversification of the highereducation system, economic globalisation, novelmodes of knowledge production, new professionalrequirements and the establishment of newvocational higher education systems in manycountries have challenged higher educationinstitutions to develop new forms ofcollaboration with working life. The newsituation also challenges higher education todevelop pedagogical and educational thinkingand practices. The purpose of this article isto examine the pedagogical aspects of theincreasing interaction and collaboration thatis taking place between higher education andworking life and to outline what kind ofchallenges it poses for research on highereducation. It is emphasised that from thepedagogical viewpoint integration betweentheory and practice in work-based learning isessential. Our general conclusion is that therelationship between higher education andworking life should be examined at least fromfour different perspectives: (1) from theviewpoint of student learning and thedevelopment of expertise, (2) from the viewpointof educational institutions and staff, (3) fromthe viewpoint of working life organisations andemployers, and (4) from the viewpoint of societyand the system of education.     

Exploring doctorate holders’ perceptions of the non-academic labour market and reputational problems they relate to their employment

Doctoral employment outside universities has been increasing, as universities cannot employ all doctorate holders. Nevertheless, it has been argued that the shift from doctoral programs to the non-academic labour market has been limited. In this qualitative study, more than 800 verbal answers given by doctorate holders to a pair of open-ended questions were content-analysed to explore doctorate holders’ perceptions of the non-academic labour market and the reputational problems they relate to their employment. The study identifies four reputational problems which doctorate holders relate to their employment: the oversupply problem, the overeducation problem, the consistency problem and the communication problem. By identifying potential reputational problems on the doctorate holders level, this research contributes novel information in terms of both theory development and practitioner insights.