The 2010 Benjamin Franklin medal in chemistry presented to Joanne Stubbe

For pioneering studies demonstrating that ribonucleotide reductases transform ribonucleotides into deoxyribonucleotides by an astonishing free-radical mechanism and for her unprecedented achievements in the study of complex biological systems through innovative chemical and spectroscopic methods.     

A microdevice for the creation of patent, three-dimensional endothelial cell-based microcirculatory networks

Microvascular network formation is a significant and challenging goal in the engineering of large three-dimensional artificial tissue structures. We show here the development of a fully patent, 3D endothelial cell (microvascular) microfluidic network that has a single inlet and outlet, created in only 28 h in a microdevice involving fluid flow equivalent to natural vasculature. Our microdevice features a tailored "multi-rung ladder" network, a stylized mimic of an arterial-to-venous pedicle, designed to also allow for systematic and reproducible cell seeding. Immunofluorescence staining revealed a highly contiguous endothelial monolayer (human umbilical vein endothelial cells) throughout the whole network after 24 h of continuous perfusion. This network persisted for up to 72 h of culture, providing a useful template from which the effects of surface chemistry, fluid flow, and environmental conditions on the development of artificial vascular networks ex vivo may be rapidly and robustly evaluated.     

Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration

Cell movement is highly sensitive to stimuli from the extracellular matrix and media. Receptors on the plasma membrane in cells can activate signal transduction pathways that change the mechanical behavior of a cell by reorganizing motion-related organelles. Cancer cells change their migration mechanisms in response to different environments more robustly than noncancer cells. Therefore, therapeutic approaches to immobilize cancer cells via inhibition of the related signal transduction pathways rely on a better understanding of cell migration mechanisms. In recent years, engineers have been working with biologists to apply microfluidics technology to study cell migration. As opposed to conventional cultures on dishes, microfluidics deals with the manipulation of fluids that are geometrically constrained to a submillimeter scale. Such small scales offer a number of advantages including cost effectiveness, low consumption of reagents, high sensitivity, high spatiotemporal resolution, and laminar flow. Therefore, microfluidics has a potential as a new platform to study cell migration. In this review, we summarized recent progress on the application of microfluidics in cancer and other cell migration researches. These studies have enhanced our understanding of cell migration and cancer invasion as well as their responses to subtle variations in their microenvironment. We hope that this review will serve as an interdisciplinary guidance for both biologists and engineers as they further develop the microfluidic toolbox toward applications in cancer research.     

Foot strike patterns of recreational and sub-elite runners in a long-distance road race

Although the biomechanical properties of the various types of running foot strike (rearfoot, midfoot, and forefoot) have been studied extensively in the laboratory, only a few studies have attempted to quantify the frequency of running foot strike variants among runners in competitive road races. We classified the left and right foot strike patterns of 936 distance runners, most of whom would be considered of recreational or sub-elite ability, at the 10 km point of a half-marathon/marathon road race. We classified 88.9% of runners at the 10 km point as rearfoot strikers, 3.4% as midfoot strikers, 1.8% as forefoot strikers, and 5.9% of runners exhibited discrete foot strike asymmetry. Rearfoot striking was more common among our sample of mostly recreational distance runners than has been previously reported for samples of faster runners. We also compared foot strike patterns of 286 individual marathon runners between the 10 km and 32 km race locations and observed increased frequency of rearfoot striking at 32 km. A large percentage of runners switched from midfoot and forefoot foot strikes at 10 km to rearfoot strikes at 32 km. The frequency of discrete foot strike asymmetry declined from the 10 km to the 32 km location. Among marathon runners, we found no significant relationship between foot strike patterns and race times.     

A Layered Framework for Considering Open Science Practices

The open science movement, although not new to social science broadly, has gained momentum recently within communication science. In response, journals in our field have begun encouraging open science practices, from data and materials sharing to submitting preregistered research reports. However, this momentum has also led to some confusion over what is and is not considered open science and what the value of open sciences practices is. In this editorial we lay out an “onion model” of open science that describes increasing levels of transparency and suggests how open science practices can be understood less as a revolutionary concept but more as a logical extension of some of the historical pillars of scientific norms. Through this model, we provide tangible steps for how scholars may begin thinking about how to introduce open science practices into their current and future empirical efforts.     

Student or scholar? Transforming identities through a research writing group

This article explores the role a writing group played in influencing the scholarly identities of a group of doctoral students by fostering their writing expertise. While the interest in writing groups usually centres on their potential to support doctoral students to publish, few studies have been conducted and written by the students themselves. Using a situated learning perspective on identity, we explore the connection that emerged between our perceptions of ourselves as developing expertise as scholarly writers and the function of the writing group as a dynamic space for transforming our identities. Findings show that our writing group served as a flexible and interactive Community of Practice (CoP) that shaped critical and durable shifts in identity amongst members.     

On Food,Farming and Land Management: Towards a research agenda to reconnect urban and rural lives

Science education has a key role to play in helping people to develop their understanding of the local and global dimensions of food, farming and land management. Based on a review of the literature on what is known about young people’s (3–19) views towards and learning about these topics, a research agenda is outlined for consideration by the science education research community.     

Co-Rumination Partially Mediates the Relationship Between Social Support and Emotional Exhaustion Among Graduate Students

Graduate students regularly report high levels of stress and burnout. Many of those same students utilize social support networks, which can act as stress buffers. This study evaluated excessive negative talk about issues (co-rumination) and its effects on that social support-to-burnout (emotional exhaustion) relationship and predicted that co-rumination would act as a suppressor variable. Graduate student volunteers (N = 213) reported their levels of social support, co-rumination, and emotional exhaustion. Data indicated that co-rumination did mediate the social support-to-emotional exhaustion relationship on 2 dimensions. This project purports that, although social support is important, the content of socially supportive interactions may also be important when attempting to intervene in stressful situations, especially when those interactions involve co-ruminative messages.